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WHAT IT DOES

Analgesic
Antipyretic

H I S T O R Y
1877 - Harmon Northrop Morse
1887 - clinical trials in,
by Joseph von Mering
1950 - Triagesic sold in the USA
HOW IT WORKS
Analgesis = pain thresh hold
Antipyresis = blocks formation/release of pyrogens

Most is metabolized in the liver
Excreted by kidneys
Some is metabolized via hepatic CYP

METABOLISM
DOSAGE & -LIFE
Recommended dosage: 650mg q.4-6.h.
Max: 3 gpd
-life : ~3 hours
LD
50
Adults: 10 g or 200mg/kg
LD
50
Children: 150 mg/kg
C H E M 1 3 1
M - T h 1 0 a m
Julie Fenich
Natali Kruk
Valentina Kruk