SILIGURI INSTITITUTE OF

TECHNOLOGY

NAME:- MOINAK DEY

3RD YEAR

5TH SEMESTER

DEPT:-BIO-MEDICAL ENGINEERING

TEACHER:- SUJAN K SAMANTA

 TOPIC OF SEMINAR

“METER DOSE DRUG DELIVERY DEVICE”

 INTRODUCTION

DRUG DELIVERY DEVICE(DDD):

These are the devices which are used to delivery various types of drugs
into the human body.This devices are used to deliver the drugs in form
of injection,injestion,absorption.This devices showed a new path to the
Bio-Medical field.

METER DOSE DRUG DELIVERY DEVICE(MDD):

They are pressurized,hand-held devices that use propellents to deliver doses of
medications to the lungs of a patient.These delivey devices are critically
important to public health and are used to administer various medications for a
range of medical conditions.MDDs plays a significant role in the treatment of
asthma and chronic obstructive pulmonary disease(COPD).MDDs are primary
DDDs used world-wide for asthma and COPD.
TYPES OF METER DOSE DRUG
DELIVERY DEVICES
Different types of devices are used to deliver
inhaled medications into the lung:-

i)INHALERS:
Inhalers are small pocket-sized containers that
enable us to inhale the madications inform of
powder or spray.

There are two types of inhalers:-

A)Meter-dose(sometimes used with spacers).
B)Dry powder.
 TYPES OF METER-DOSE DRUG
DELIVERY DEVICE(CONTD…)
A)Meter-dose Inhalers:
In the recent days doctors are
recommending mostly meter-dose
inhalers for asthma patients.

This consists of:-

A metal canister inside a plastic
dispenser.Canister holds the spray
and when pressed & released it
delivers required amount of
medications.
Medication is stored under pressure in the canister and released in
fixed volumes from the dosing chamber following actuation.
One should use the device in a proper
manner to deliver the drug in a
proper way into the target.
 TYPES OF METER-DOSE DRUG
DELIVERY DEVICE(CONTD…)
Spacers:
These are useful for making
meter-dose inhaler (MDIs) for
easier & effective.A specier is
a hollow chamber that fits into
the mouth-piece of the meter
dose inhaler.
This device is useful to prevent
any urgency.The drug To maximize drug delivery, a spacer should be employed by all patients.
Infants and young children should use spacer with a facemask (as shown
released stays for sometime in above),low dead space, and a low resistance valve.

chamber then can be

breathed. Courtesy of Richard Scarfone, MD, FAAP.

AeroChamber, (B) AeroChamber with mask, and (C) InspirEase.

se devices can facilitate the use of metered dose inhalers
decrease the amount of drug deposited on the upper airway.
 TYPES OF METER-DOSE DRUG
DELIVERY DEVICE(CONTD…)
B)Dry Powder Inhalers:
This device instead of generating
a pressurized spray,releases a
fine,micronized powder as
inhaled.

In Dry powder is easier to use

than MDIs because,co-
ordination between breathing
and device is not required in
dry powder inhalers(DPIs).

Available DPIs includes:-

Diskus,Flexhaler,Handinhaler,
Diskhaler and Aerolizer. With these devices, the patient inhales the medication in the form of a fine powder
rather than an aerosol. (A) Aerolizer, (B) Flexhaler, (C) Diskus, (D) Diskhaler,
(E) HandiHaler. Courtesy of Dean Hess, RRT, PhD.
 TYPES OF METER-DOSE DRUG
DELIVERY DEVICE(CONTD…)
Nebulizer:
It delivers a steady aerosol mist of
medicine through a face mask or
mouth-piece,allowing to breathe
normally during an ongoing treatment.
This device consists of a chamber
containing drug(liquid) and compressor
pump.
Traditionally operated nebulizers are
recently replaced by ultra-sonic
nebulizers,which are battery operated
& expensive.

Advantage:-
Plenty of medicines is delivered.

Disadvantage:-
Lack of convenience(i.e. Difficult to carry).
 METERED DOSE INHALER
CANISTER AUTO TESTER
The MDI Autotester system tests MDI aerosol canister for
drug delivery to the lungs using a shaker more alike with
that of human shaking motions than any system
developed previously.The system picks MDI canisters
from two racks and services two shaking arms using
predefined shaking patterns(so keeping all testing the
same & reducing the error found due to different
operators testing the canisters).Each canister is
weighed,fired & analysed multiple times to generate
accurate data of how each canister performs over its
lifetime.Batch testing of the canister indicates the
accuracy of drug dispensing & variations between
batches & valves.
METERED DOSE INHALER
CANISTER AUTO TESTER
 PELLET SYSTEM

INVENTION:

The present invention resolves the problems previously outlined and

provides a greatly improved parasiticidal pellet system which delivers
separate doses of both immediate and long term control of parasite
infestation in an animal as part of a single implant procedure wherein the
immediate dose is sufficient to kill pests already present in the animal
and the long term dose is sufficient to prevent reinfestation.
 PELLET SYSTEM(CONTD…)
OBJECTIVES AND ADVANTAGES OF THE
SYSTEM:
i)Providing multicomponent parasiticidal pallet system.
ii)Providing a pellet system for immediate as well as sustained delivery
of a parasiticide in order to kill doth internally and externally present
within the animal which may reinfest the animal in future.
iii)Providing such a system and method which permits injection of
predetermined doses of each of a parasiticide for immediate release
and a parasiticide for extended release in a single injection.
iv)Providing such a system and a method which permits subcutaneous
injection of both an immediate release parasiticidal dose and an
extended release parasiticidal dose.
 PELLET SYSTEM(CONTD…)

v)Providing such a system and a method which permits an

operator to selectively inject an extended release
parasiticical dose into the needle.
vi)Providing such a system and method which permits
serial injection of large no. of animals in single session.
vii)Providing such a system and method which is
simple,efficient and economical to manufacture,which
prevent reinfestation for a longer period (upto 150 days).
 IMPLANTABLE METERED DOSE
DRUG DELIVERY DEVICES
An implantable metered dose drug delivery system is disclosed which
comprises implantable components including an injection
site,reservoir,metering valve and delivery catheter,all of which are
interconnected through suitable tubing.The metering valve has a
domed body constructed of a resilient elastomeric material with a
fluid-flow passageway extending therethrough and opening into a
chamber within the domed body.A valve is positioned within an
outlet leading from the chamber,which valve is opened by exerting
an external pressure on the domed body to first collapse and
occlude the fluid-flow passage way and the open the valve to permit
medication within the chamber to flow through the outlet.When
external pressure is released,the fluid flow passway opens and the
reduced pressure in the chamber draws additional fluid through the
passageway to the chamber.
NECESSITY OF METERED DOSE
DRUG DELIVERY DEVICE
Transporting drugs to specific and appropriate tissues of the body is not a trivial
issue and can be more important than the benefits of the drug itself.
Characteristics of the target tissues and of the drug-chemistry must be
considered before a treatment can be effective.
Delivery issues are largely linked with the drugs stability,mechanisms for
metabolism of each drug, the tolerance and reaction of the body to the drug
and the permeability of the target tissue.
Currently, drug delivery techniques focus on moving drugs past our body’s
barriers and into the blood stream,where it will be supplied to organs and
tissues. This is done by ingestion,inhalation,absorption and injection.
In the year 1990’s Applied Physics Laboratory(APL) invented a type Of DDD
which can overcome the obstacles and cross the various barriers to supply
drugs to various organs and tissues which were used to be obstructed
earlier and thus proved to be an effective device.
 CONCLUSION
This metered dose drug delivery devices proved to
be a boon the mankind and obviously to the
recent the medical science treatment.
The functions which were not done by the normal
dug delivery devices the metered dose drug
delivery devices made the way,thus fading new
horizon on the Bio-Medical field,and leading to
its development.
The patients could find themselves more and more
relaxed and less tension with the invention of
this metered dose drug delivery devices.
 REFERENCE
 www.google.com
 www.labman.co.uk/Robot_MDIT.html
 www.acaai.org/public/
 www.nlm.nih.gov/medlineplus/healthtopics.html
 http://www.arap.org/docs/MDI907_Final.pdf.
 www.clementclarke.com/.../index.html