Gold Pharm Anti-infectives

Primaquine

Malaria profylaxis Used for extraerythrocytic forms Plasmodium vivax or P. ovale

 Sulfonamides

PABA structural analogs Inhibit Folic acid synthesis

 Tertacyclines, anuria & the exception

Should not be used in anuric pt due to production of (-) Nitrogen balance & increased BUN levels. Doxycycline is the exception

 Ceftriazone

3rd generation cephalosporin DOC for bacterial meningitis in kids (ie.. HiB) One dose txt of gonorrhea

 Hepatic coma DOC

 Neomycin (aminoglycoside) - it supresses the normal flora = decreasing NH4 production = decreasing free nitrogen levels in the bloodstream.

 Clavulanic acid

 Irreversible (-)r of lactamases, but ot of transpeptidase = use w/ a lactamase sensitive penicillin

 Piperacillin

Txt Pseudomonas aeruginosa & Klebsiella Broad spectrum antibiotic

 Pyrantel Pamoate

Txt of Hookworm disease Depolarizing NMJ ()r

 Cefoxitin

Txt intraabdominal infections (ie.. w/ Bacteroides fragilis) Traditional txt has been Clindamycin & Gentamycin

 Chloramphenicol

Broad spectrum antibiotic Bone marrow depression (common) - Aplastic anemia (rare) Gray baby syndrome (chloramphenicol cannot be conjugated) DOC Typhoid Fever (symptomatic Salmonella infection) DOC HiB meningitis in kids especially resistant strain to ampicillin

 Nifurtimox

Txt trypanosomiasis

 Metronidazole

Txt Leishmaniasis & Amebiasis Good for anaerobic bacteria = Bacteroides fragilis DOC Trichomoniasis DOC Giardia lamblia

 Tetracycline

Txt of Brucellosis & Cholera Txt Rocky Mountain Spotted Fever Txt spirochete infections = Lyme disease (Borrelia burgdorferi)

 TMP-SMX

 (-) dihydrofolate reductase activity

 Benzathine Penicillin G

Long duration of action = given once every 3-4 weeks for Txt of Syphilis

 Praziquantel

Txt Schistosomiasis (trematode [fluke] infections)

 Melarsoprol

Txt Trypanosomiasis that has neurological symptoms

 Stibogluconate

Txt Leishmaniasis

 Fluconazole

 Txt fungal encephalitis

 Amphotericin B

 Polyene antifingal

 Griseofulvin MOA

Accumulates in keratinized layers of the skin = used in dermatomycoses infections

 Mefloquine

Anti malarial Txt Chloroquine resistant strains = P. falciparum

 Chloroquine

 Txt for Malaria when inside RB

 Nifurtimox

 DOC Chagas disease due to Trypanosoma cruzi

 Erythromycin

Used in pts allergic to penicillins

 Acyclovir

Guanine analog Txt Herpes infections

 Imipenem

Used w/ Cilastatin Can cause seizures

 Cefoperazone side effects

Bleeding due to vit K level alterations Contraindicated in pts w/ bleeding disorders

 Meropenem

used w/ Cilastatin Does not cause seizures (cf w/ Imipenem)

 Nafcillin

 Only penicillin that does not need dose adjustment in renal impairment

 Peripheral neuropathy

Seen w/ use of: Metronidazole Isoniazid - Vincristine ddI - AZT - Allopurinol

 for gonorrhea

 O.N.E. Fluoroquinolones used in a one dose deal for gonorrhea: O = Ofloxacin N = Norfloxacin E = Enoxacin

 Ribavirin

 Txt RSV (Respiratory Syncytial Virus)