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4. Magnetic Resonance 2
Imaging.
5. Scintigraphy.
2_3_4_5
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1
Is this conventional or
computer tomogramm?
1
2
3
1
1 conventional lateral head tomogramm
2 computer head tomogramm
4
2
Is this conventional or computer
tomogramm?
1
2
2
1. Conventional chest tomogramm
2. Computed axial tomogramm of the chest
4
3
Which of images is made
after IV contrast
administration?
1 2
2 4
Which of images is made after IV
and per oral contrast
administration?
1 2
1 5
Computed Axial Tomography
10
Magnetic Resonance
Imaging
11
How do molecules behave as
magnets?
The ability of some atoms to behave like tiny
magnets when exposed to a magnetic field
is central to MRI physics.
Within a human body the main atom that we
are interested in is hydrogen although any
atom with an odd number of protons can
behave in this way.
The reason the hydrogen atom is so
informative is that it is present in such
huge quantities in the body.
There are more than one thousand billion
billion hydrogen atoms in an adult, mostly
in the form of water.
H2O
12
• The single proton that makes up
the nucleus of the hydrogen atom
spins around its axis and the
spinning creates a magnetic field.
• This is a property known as spin.
• The protons are all acting as little
magnets each aligned in a
different direction.
• When a large magnetic field is
applied they all try and line up with
the external magnetic field.
13
What happens to protons (Hydrogen
atoms) within a magnetic field?They
precess.
• However, instead of physically
moving to line up with the magnet
they precess.
• Precession is similar to what
happens to a spinning top just
before it falls over.
• The top wobbles towards the
ground due to the force applied by
gravity.
• In MRI it is the magnetic field that
causes the wobble.
spinning top
• In this case the wobble is towards
the magnetic field, rather than
towards the ground.
14
Precession
• Precession slow movement of the axis
of a spinning body around another
axis due to a torque (such as
gravitational influence) acting to
change the direction of the first axis.
• It is seen in the circle slowly traced
out by the pole of a spinning
gyroscope.
15
What happens to a person within a
magnetic field? Within an MRI scanner, a
person becomes slightly magnetized.
•The protons exposed to a magnetic field do not all
line up in the same direction.
•About half line up in the direction of the magnetic
field and about half are aligned in the opposite
direction.
•Therefore the magnetic effect of most of the
atoms is cancelled out.
•However, because it is slightly easier to be
aligned with the magnetic field (the aligned
position is at a lower energy state), about 10
additional hydrogen atoms are aligned with the BO
field for every one million that cancel each other
out.
•Thus there is a slight net magnetization in line
with the magnetic field.
•It is these unmatched atoms that are essential to
produce the image.
16
MRI scanner is
• The MRI scanner is primarily a
large magnet with a hole in the
middle.
• The magnetic field required to
produce MR images is huge.
• The strength of the main MRI
magnetic field is known as B0
(B-zero).
• UK guidelines allow a maximal
B0 of 4.0 Tesla (40 000 Gauss)
compared to the Earth's
magnetic field of 0.5 Gauss
• most MRI scnners have a B0 of
between 0.5T and 1.5T.
17
What happens next?
Resonance!
• All objects vibrate at a certain speed,
known as the natural or resonant
frequency.
• When the object is forced to vibrate at its
resonant frequency there is a large
increase in the amplitude of vibration.
• The energy causing the object to resonate
is absorbed and is subsequently released.
• When a glass is forced to resonate by
musical note, sung by an opera singer for
example of the same frequency as the
glass natural frequency the release of
energy causes the glass to shatter.
18
• The resonant frequency of the protons is
known as the Larmor frequency and is
dependent upon the tissue being imaged
and the strength of the magnetic field.
• A radio frequency (rf) pulse at the
Larmor frequency causes the protons to
precess in a different direction .
• SO resonant absorption of energy by the
protons due to an external oscillating
magnetic field will occur at the Larmor
frequency of external signal.
• The hydrogen atoms, which have the
same frequency as the radio wave, will
become 'excited' (that is, they will be
raised to a higher state of energy) and
start to resonate with the exciting wave.
19
Allowing this field to return to
its original orientation
(relaxation)
When the radio signal is
turned off, the hydrogen
atoms will, after a period of
time, return to their original
energy state.
The excitation energy, which
they had gained, will be
released in the form of radio
waves, which are detected by
the MRI machine.
This emitted energy is called
an echo!
Detecting and measuring the
field after relaxation
22
Signal intensity
• The correct descriptive terminology
for the grayscale seen on MRI is
signal intensity. 5
• High signal is appear white.
• Low signal is black. 3 4
2
T1 and T2 imaging
• There are two main forms of MRI, known as
T1 weighted and T2 weighted.
• The two image types are also known as T1
contrast and T2 contrast.
• As these names imply, the reason that more
than one image type is required is that
some tissues are contrasted better, and
thus are easier to see, with one technique
rather than the other.
• T1 contrast shows better anatomical detail
and better distinction between solid and
cystic structures. T2 contrast shows
pathological changes better.
24
• A 90-degree pulse is used to displace the
T1 Weighted protons.
• The protons are rotated around into the
Imaging X-Y plane where they precess in phase
(in time with each other).
• After the RF pulse is switched off the
protons come out of phase (dephase).
• The decaying signal sent out as the
protons return to the Z-plane is
measured over a time known as TR.
• The faster protons realign the stronger
the signal that is emitted.
• Early measurement of this signal is
required to differentiate between various
tissues.
• To maximize T1 contrast a short TR
sampling time must be used.
• In T1 imaging you are measuring
how the protons realign relative to
the external magnetic field.
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T2 Weighted • However, as the protons dephase a
180-degree pulse is fired which puts
Imaging them back in phase.
• After this second pulse is switched
off the protons again dephase.
• In a T2 image we are looking to
emphasise tissues which remain in
phase for a long time and therefore
maintain a strong signal.
• This can be achieved by delaying
the sampling time after the 180-
degree pulse (a time known as TE).
• To maximize T2 contrast a long TE
sampling time must be used.
• In T2 imaging you are measuring
how the protons realign relative
to each other.
26
T1 and T2 imaging
27
T1
T2
• Obviously it is a lot easier to identify a structure if you know what type of tissue it is.
• The colours of the structure in the image provide this information.
• The colours are not the same on T1 and T2 weighted images.
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Substance T1 weighted T2 weighted
Water Dark grey Light grey or white
Fat White Light grey
Muscle Grey Grey
Air Black Black
Cortical bone Black Black
Fatty bone marrow White Light Grey
Liver Grey Grey
Spleen Grey Grey
Flowing blood Black Black
Brain: White matter Light Grey Grey
Brain: Grey matter Grey Very light grey
CSF in ventricle Dark grey Light grey or white
CSF fast flowing Dark grey or black Dark grey or black
29
Low signal is black
• Air (1)
• Cortical bone (2) 5
• Flowing blood (3)
• Fibrous tissue (4)
4
3
• Water (5)|edema (on
T1)
6
2
High signal intensity (white)
• Fat (and other
lipids - 1) 2
• Hemorrahage
• High protein
• Melanin
• Microcalcifications 1
• Water (2)|edema
(on T2)
Special terms
used on MRI
reports:
•T 1 images (with
low signal from
water structures)
•T2 images (with the
high signal from
water)
•Highsignal intensity
•Low signal intensity
• MR images are most commonly T1,
they are the best for visualizing
anatomy.
• T2 weighted is better for visualizing
the disease.
• MR images can also be a mixture of
both called proton density weighting.
• FLAIR sequences produce heavily T2
weighted images they are good to
determine the edema and ischemia of
tissues.
33
The basic phenomena involved in
magnetic resonance experiments may
be classified into the following four
groups:
1. Inducing a magnetic field in the sample
2.Reorienting this magnetic field by a
known amount (the"spin flip")
3.Allowing this field to return to its original
orientation (relaxation)
4. Detecting and measuring the field after
relaxation is underway
MRI T1-weighted Images
35
MRI T2-weighted Images
36
Magnetic resonance angiography
• Resonance Angiography (MRA)
are a group of techniques based
on MR to image blood vessels.
• Magnetic Resonance Angiography
is used to generate images of the
arteries in order to evaluate them
for stenosis, occlusion, aneurism
• MRA is often used to evaluate the
arteries of the neck and brain, the
thoracic and abdominal aorta, the
renal arteries, and the legs (called
a "run-off").
37
A variety of techniques can be used to
generate the pictures, based on flow
effects or on contrast (inherent or
•
pharmacologically generated).
The contrast medium is injected into a
vein, and images are acquired during
the first pass of the agent through the
arteries. Provided that the timing is
correct, this may result in images of
very high quality.
• An alternative is to use a contrast
agent that does not, as most agents,
leave the vascular system within a
few minutes, but remains in the
circulation up to an hour (a "'blood-
pool agent'"). Since longer time is
available for image acquisition, higher
resolution imaging is possible. A
problem, however, is the fact that
both arteries and veins are enhanced
at the same time.
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A variety of techniques can be used to
generate the pictures, based on flow
effects or on contrast (inherent or
•
pharmacologically generated).
Time-of-flight (TOF) or Inflow
angiography, uses a short echo time
and flow compensation to make
flowing blood much brighter than
stationary tissue.
• As flowing blood enters the area
being imaged it has seen a limited
number of excitation pulses so it is
not saturated, this gives it a much
higher signal than the saturated
stationary tissue.
• As this method is dependent on
flowing blood, areas with slow flow
(such as large aneurysms) may not
be well visualized.
• This is most commonly used in the
head and neck and gives detailed
high resolution images
39
A variety of techniques can be used to
generate the pictures, based on flow
effects or on contrast (inherent or
•
pharmacologically generated).
Phase-contrast (PC-MRA) the
phase of the MRI signal is
manipulated by special gradients
(varying magnetic fields) in such
a way that it is directly
proportional to velocity. Thus,
quantitative measurements of
blood flow are possible, in
addition to imaging the flowing
blood.
40
A variety of techniques can be used to
generate the pictures, based on flow
effects or on contrast (inherent or
pharmacologically generated).
• Fresh blood imaging (FBI):
An imaging technique
using fast or super fast
spin echo sequences
(FSE/SFSE). Takes
advantage of the longer T2
relaxation of blood
compared to surrounding
tissue. The images are
acquired by fast spin echo
sequences that can be
synchronized with heart
beats
41
A variety of techniques can be used to
generate the pictures, based on flow
effects or on contrast (inherent or
pharmacologically generated).
• 4D Dynamic MR
Angiography (4D-MRA):
• The first images, before
enhancement, serve as a
subtraction mask to
extract the vascular tree in
the succeeding images.
Allows to divide arterial
and venous phases of a
blood-groove with
visualisation of its
dynamics.
42
Magnetic resonance
cholangiopancreatography replaced
ERCP
43
Endoscopic retrograde
cholangiopancreatography (ERCP)
ERCP is used primarily to diagnose
and treat conditions of the bile
ducts, including gallstones,
inflammatory strictures (scars),
leaks (from trauma and surgery),
and cancer.
45
Functional MRI
• measures signal changes in the brain hat are
due to changing neural activity.
• The brain is scanned at low resolution but at a
rapid rate (typically once every 2–3 seconds).
• Increases in neural activity cause changes in
the MR signal via T2* changes.
• this mechanism is referred to as the BOLD
(blood oxygen level dependent effect).
• Increased neural activity causes an increased
demand for oxygen, and the vascular system
actually overcompensates for this increasing
the amount of oxygenated hemoglobin relative
to deoxygenated hemoglobin. Because
deoxygenated hemoglobin attenuates the MR
signal, the vascular response leads to a signal
increase that is related to the neural activity.
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Differentiating between MRI and
CT
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Where is MRI?
1 2
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Patient Safety
•Pacemaker
•Metal implants
•Neurostimulator (TENS-unit)
•Intrauterine device (IUD),etc.
•Aneurysm clips
•Surgical staples
•Implanted drug infusion device
•Foreign metal objects in the eye
•Shrapnel or bullet wounds
•Permanent eyeliner
•MRI is not generally recommended for pregnant
patients, especially during the first trimester.
In 2006, a new classification system for implants and ancillary clinical devices has
been developed by ASTM International and is now the standard supported by the US
Food and Drug Administration: MR Safe signMR-Safe — The device or implant is
completely non-magnetic, non-electrically conductive, and non-RF reactive,
eliminating all of the primary potential threats during an MRI procedure. MR
Conditional signMR-Conditional — A device or implant that may contain magnetic,
electrically conductive or RF-reactive components that is safe for operations in
proximity to the MRI, provided the conditions for safe operation are defined and
observed (such as 'tested safe to 1.5 teslas' or 'safe in magnetic fields below 500
gauss in strength'). MR Unsafe signMR-Unsafe — Nearly self-explanatory, this
category is reserved for objects that are significantly ferromagnetic and pose a clear
and direct threat to persons and equipment within the magnet room.
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Magnetic Resonance
• Imaging
Advantages
☺ Non-ionizing radiation. Because MRI does not ionize tissue it is considered
amongst the safest of radiological techniques. There are no known physiological
side effects of being exposed to a magnetic field.
☺ High soft-tissue contrast. MRI images provided very detailed information about
soft tissues. They can differentiate between normal and abnormal tissues and
may show damage missed on CT
☺ Images can be produced in any plane. This is great value in studies of the Central
Nervous System.
☺ Visualisation of areas deep within bony structures. MRI is thus invaluable for the
diagnosis and treatment of brainstem tumours.
☺ Shows vasculature without contrast. Because the patient is not subject to any
invasive procedure (i.e. the injection of contrast media) the technique is less
unpleasant.
☺ Good for angiography. MRI is excellent for imaging blood flow and studying heart
function. Functional MRI maps changes in blood flow in the brain during specific
tasks. This provides valuable information about how the brain works.
☺ 3D imaging. Computer manipulation of the digital data can be used to produce
exact three-dimensional images of organs. A further development is the
production of perfect-replica models of organs using the digital information.
Magnetic Resonance
Imaging
• Disadvantages
☹ High cost of equipment. An MRI scanner can cost over GB£ 1 500 000 (US$ 2 400 00) to
purchase.
☹ Claustrophobia. Up to 10% of patients experience claustrophobia during an MRI scan
and 1% of scans have to be aborted because of it.
☹ Long imaging time. A complete image may take up to 30mins and movement at the
wrong time can cause artefacts in the image. However, new techniques have reduced
imaging time.
☹ Strong magnetic field. MRI imaging is unsuitable for many patients with metal implants
(e.g. artificial joints) and is especially dangerous for patients with pacemakers, neural
stimulators, or cochleal implants. Loose metal objects must be removed before coming
near to the scanner otherwise they may be attracted so strongly by the magnet that they
fly through the air like tiny missiles!
☹ Unable to image calcium. Because MRI detects water rather than molecular density,
calcium is not well visualized. This means that tissue calcification, a feature of a number
of disease processes, can not be detected. Bone is also less obvious than on a CT scan.
☹ Acoustic noise. Switching on and off of the gradient coils causes repeated loud bangs.
Noise levels may reach 95 dB for much of the scan. Ear plugs are advisable to reduce the
risk of temporary or even permanent hearing loss.
☹ Various minor biological effects. At high field strengths direct stimulation of muscles or
nerves are may be experienced. Some patients experience visual flashes
(magnetophosphenes) produced by stimulation of the optic nerve. Although there are no
known harmful effects on the foetus scanning is avoided during pregnancy, especially
during the first trimester, unless the alternatives are more dangerous (e.g. ionizing
radiation)
Indication for MRI
• White matter diseases • Pathology of liver
(Leukoencephalopathy),
and ducts,
• Acute Brain Infarction,
• Spinal Cord Problems, • Pelvic pathology,
• Posterior fossa diseases, • Pediatric patients,
• Head trauma,
• Vessels and Heart
• Joint pathology and trauma,
pathology.
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Pelvic pathology
Dilated cardiomyopathy, M-
Mode
B (brightness)-mode
• Gives 2 D slices
that map the
different
magnitudes of echo
in gray scale
B (brightness)-mode.
Advantages Disadvantages
☺It does not use ☹ Is highly dependent on
ionizing radiation, the operator, not least
☺Real-time imaging, due to his/her ability to
☺Multy planar imaging, interprete the images
correctly and evaluate in
☺Non invasive vascular a proper clinical setting,
imaging (vessels),
☹ Poor quality in obese
☺Portable, quick, subjects
cheap.
☹ Interference from bone,
bowel gas, calculi and
other superimposed
structures.
Contrindication for Ultrasound
•NO
•
Pancreas and gall bladder diseases.
The appears swollen, edematous and
hypoechoic. These findings suggest
acute pancreatitis.
79
Carotid angioplasty and stenting.
Angiography before and after.
80
Interventional Endoscopic retrograde
cholangiopancreatography
ERCP, CBD Stones ERCP after endoscopic operation
81
Biopsy of lung tumor
General suggested
readings
• Essentials of radiology by Fred A. Mettler Jr.
Publisher: Saunders. 2004.
• Radiology by Amit Mehta, Douglas P. Beall,
Publisher: Humana Press. 2007.
• Clinical Radiology Made Ridiculously Simple
(Paperback) by Hugue Ouellette, Patrice
Tetreault, 1999.
• Learning Radiology: Recognizing the Basics: On
Timeby William Herring Textbook.
Publisher: Elsevier Science. 2007.
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