Sei sulla pagina 1di 23

Weight Management Gene Expression Science

Advances in Gene Expression Science


Allow Scientists to Compare & Contrast Expression Patterns of two Biological States
Biological State #1 Biological State #2 State

Comparison of Genetic Profiles of Adipose Tissue in Identical Twins


Normal Weight Twin
Pietilinen et al. PLoS Med. 2008 Mar 11;5(3):e51.

Overweight Twin

Same DNA

Different Expression of Genes

Compared to their normal weight twin, overweight twins exhibited down regulation of gene expression pathways related to:
Fat Regulation (storage versus utilization) Muscle Protein Synthesis

Deep understanding of gene expression science


Nu Skin owns patented technologies to study anti-aging interventions through gene expression science

Identified Gene Expression Pathways Linked to Fat Storage and Fat Metabolism

LifeGen pre-clinical study of Adipose, Gastrocnemius muslce, Hypothalamus

Gene Expression relates to the Appetite Control Center of the Brain


Ghrelin Leptin Insulin
1. 2. 3. 4. 5. 6. 7. 8. 9.

Appetite Control Eating Behavior Regulation of energy intake

References:
Smeets et al. Proceeding of the Nutrition Society. 2012;71:511-520. Guthoff M, et al. J Clin Endocrinol Metab. 2010;95:748-755. De Silva, et al. Cell Metab. 2011;14:700-706. Malik S, et al. Cell Metab. 2008;7:400-409. Farooqi IS, et al. Science. 2007;317:1355 Suzuki K, et al. Experimental Diabetes Research. 2012:1-19. Viquerie N, et al. Diabetologia. 2005;48(1):123-131. Mager et al. European Journal of Endocrinology. 2008;158: Mutch DM, et al. Am J Clin Nutr. 2011;94(6):1399-1409.

Formulations Based on:


Proprietary gene Expression Research The latest and most robust nutritional science

Eating Plan Based on: Protein Science & Nutrition Science


An eating plan designed to complement the supplements. Supports metabolically-active lean muscle and inhibits fat storage1

Reference: Wycherley TP, et al. AJCN. 2012;96(6):1281-98.

Typical Reduced Calorie Diet 2000 kcal


Fat Burning Foods Proteins Proteins
(90g) (90 g)

Fat Storing Foods

Carbohydrates Carbohydrates
(260g) (260 g)

Fat Storing Foods

Fats Fats
(67g) (67 g)

Typical Reduced Calorie Diet 1200 2000 kcal


Fat Burning Foods Proteins Proteins
(90g) (45 g)

Fat Storing Foods

Carbohydrates Carbohydrates
(260g) (180 g)

Fat Storing Foods

Fats Fats
(67g) (33 g)

Eating Plan 1200 kcal


Fat Burning Foods Proteins Proteins
(90g) (90 g)

Fat Storing Foods

Carbohydrates Carbohydrates
(260g) (260 g)

Fat Storing Foods

Fats Fats
(67g) (67 g)

Eating Plan 1200 kcal


Fat Burning Foods Proteins Proteins
(90g) (90 g)

Fat Storing Foods

Carbohydrates Carbohydrates
(260g) (120 g)

Fat Storing Foods

Fats Fats
(67g) (40 g)

Eating Most of Your Protein with Only One Meal of the Day Limits Duration of Metabolic Burn
FAT BURNING

Time in Metabolic Burn Zone = Only 3 hours/day

ZONES

FAT STORING

Breakfast

Lunch

Dinner

Adapted from: 1. Paddon-Jones and Rassmussen. Curr Opin Clin Nutr Metab Care, 2009;12:86. 2. Layman DL. Nutrition and Metabolism, 2009; 6:12.

Eating Protein with Each Meal Accelerates Metabolic Burn


FAT BURNING

Time in Metabolic Burn Zone = 9 hours/day

ZONES

FAT STORING

Breakfast

Lunch

Dinner

Adapted from: 1. Paddon-Jones and Rassmussen. Curr Opin Clin Nutr Metab Care, 2009;12:86. 2. Layman DL. Nutrition and Metabolism, 2009; 6:12.

Open Label Clinical Study


- 90 Days on ingredients-based program - 45 women and 21 men completed the study
Participants Reported - Lower levels of Hunger - Changes in body silhouette - Clothes fit better - Liked this program better than programs they had tried previously
Results of unpublished preliminary study 2013

ageLOC TR90 Summary


Healthy weight management and Body Shaping program. Based on gene expression science, addresses key factors related to weight management:
- Healthy Metabolism, - Promotes Lean Muscle Maintenance - Appetite Control

Studies on TR90 weight management program resulted in significant weight loss, fat loss and changes in gene expression.

Nutrition Science
Gene Expression Science SIGNS & SYMPTOMS
17

Antioxidant Science

LIFEPAKTHE PERFECT COMPANION


Nutritional foundation is important
LifePak provides that foundation

Ensure adequate nutrition during reduced calorie regimen Dietary antioxidants for added protection from oxidative stress

LifePak Off-sets Oxidative Stress During Dieting


Participants took LifePak Scanner Scores increase an average of 6,000 per person
Average SCS for study participants
40,000 30,000 20,000 10,000

36,000 29,000 30,000

Baseline

6 Weeks

12 Weeks

Data from My Victory Open-label Study 2007

AGELOC R2 The Perfect Companion


Maintain energy levels

Assist with cell renewal and cleansing during lipolysis

TR90 SUPPORT TOOLS

WHATS YOUR TRANSFORMATION NUMBER?


Create and communicate your personal transformation through a compelling story and transformation number that is completely unique to your ageLOC TR90 experience.