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Widya Arsa
Introduction
Become major health problem Canada: 1 of 4, 1 0f 8 USA: > 1 million fragility fracture cost US$ 10 billion In 2041, elderly people > 25% Preventable disease
Resorption by osteoclasts
Osteoblasts
Bone remodelling
Sincere thanks to Dr. Susan Ott from the University of Washington for permission to use the above images
Normal Bone
Osteoporosis
Bone Regulation
Definition
characterized by low bone mass and microarchitectural deterioration of bone tissue, leading to enhanced bone fragility and a consequent increase in fracture risk
Definition
United States National Institutes of Health (2000) a skeletal disorder characterized by compromised bone strength predisposing a person to an increased risk of fracture. Bone strength reflects the integration of 2 main features: bone density and bone quality.
Normal
Cortical
Osteopenia
Osteoporosis
Severe Osteoporosis
Trabecular
Sincere thanks to Dr. Susan Ott for permission to use the above images
Classification
Primary Osteoporosis Type 1 high turnover Type 2 low turnover Secondary Osteoporosis (type 3)
Classification
Type I (high turnover) Early menopause 10 yrs after
Classification
Type 2 low turnover th or 8th Decade 7 Osteoblast activity due to aging, nutritional insufficiency Losses 0,5% annually # at minor trauma
Classification
Type 3 Careful : < 50 yo, rapid bone loss Underlying disease
Risk Factors
"silent disease"
Back pain Decreased in height Kyposis Fracture caused by minor trauma (Pathological fracture)
Osteoporosis
Fracture locations
Osteoporosis detection
2.
3. 4.
5.
Dual-energy x-ray absorptiometry (DEXA) Calcaneal quantitative ultrasonometry (QUS) Quantitative CT Radiographic absorptiometry Single-energy x-ray absoprtiometry
Singh Index
Osteoporosis detection
Aim: early intervention to ensure retention of bone mass, preserve structural integrity, prevent fragility fracture
Non-pharmacological intervention
4 8 yo: 800 mg 9 18 yo: 1300 mg Premenopause: 1000 mg Male < 50 yo : 1000 mg Menopause & male > 50 yo: 1500 mg Pregnant & lactating: 1000 mg
Non-pharmacological intervention
Vit D3 more potent than D2 Maintain adequate protein intake Physical activity imapct type Prevention of fall
Osteoporosis prevention
Vitamin D
Exercise
Fall Prevention
Pharmacological intervention
1.
2. 3. 4.
5.
Estrogen (hormone replacement therapy/HRT) Biphosphonate Calcitonin Selective estrogen-receptor modulator (SERM) Iprivlafone
Pharmacological intervention
Operative treatment
If theres any fracture Vertebrae vertebropalsty, kyphoplasty Hip ORIF, hemiarthroplasty Wrist ORIF
Surgery