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E N D O M E T R I O S I S
S Y M P T O M S
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ELIMINATED DIAG NOSIS TREAT MENT GOAL EVALU ATION WHEN HOW
SYMPTOM
Clinical sign Laboratory Imaging Laparoscopy
Medical : What & how Surgical : ablation Excision, Resection -Laparoscopy -Laparotomy Surgical + medical IVF (infertility)
FAIL ?
Next Treatment
DIAGNOSIS ENDOMETRIOSIS
1. ANAMNESA
2. Klinik. 3. Laboratorik. 4. Trans Vaginal Sonography (TVS). 5. Laparoskopi.
NYERI
- CHRONIC PELVIC PAIN - DYSMENORRHEA - INTERMENSTRUAL PAIN - DYSPAREUNIA
PHYSICAL EXAMINATION
TYPICALLY NORMAL
KADANG-KADANG
- Plaque pada fornix posterior - ??? Pada recto vaginal - Uterus fixation - Focal tenderness / ??? - Uterosacral ligaments
DIAGNOSA LABORATORIK
CA 125 CELL SURFACE ANTIGEN
ADVANCE ENDOMETRIOSIS
CA 125
SENSITIVITY ( + 50%) SPESIFICITY ( + 90%)
SCREENING TEST IS NOT TOO EFECTIVE
TVS
USEFUL FOR DETECTION OF
OVARIAN ENDOMETRIOSIS
NOT FOR PELVIC ADHESIONS OR SUPERFICIAL PERITONEAL PLAQUE
TREATMENT OF ENDOMETRIOSIS
SYMPTOMATIC
PAIN
DIAGNOSIS LAPAROSCOPY
DANAZOL vs GnRH agonist 15 trial No difference in pain relief PROGESTINS vs GnRH agonist 3 trials No difference in pain relief OC vs GnRH agonist 1 trial OC have less relief of dysmenorrhea and dispareunia
Specific therapy
Continue therapy
SURGICAL THERAPY
Radical
Conservative
39 women randomized to excision or diagnostic laparoscopy Improvement at 6 month : Diagnostic laparoscopy Excision of endometriosis
Abbot JA et al, JAAGL 2002 ; 9 : S1
22 % 73 %
SURGICAL TREATMENT
2 year pain recurrence Excision (178 ) Ablation ( 39 ) 42 % 77 %
SURGERY OR MEDICAL THERAPY : 6 MONTHS POST TREATMENT Pain relief : Telimaa (MPA) Telimaa (Danazol) Sutton (Surgery) 50 % 74 % 47 %
Therapy with a GnRH agonist is an appropriate approach to the management of the women with chronic pelvic pain, even the absence of surgical confirmation of endometriosis, provide that a detail initial evaluation fails to demonstrate some other cause of pelvic pain
DIAGNOSIS
TREATMENT
EVALUATION
GOAL
Clinical Sympt.
Lap. Dx
Surgery ( Lap )
Medical
Dx
Tx
Peritoneal
Ovarial
Rectovaginal
Lysis Excision Resection Drainage Ablation
Ablation Excision
Drainage
Adhesiolysis Excision
Laser (evaporation Thermal L (electrical)
Removal (cystectomy)
Malignant
0,7 1,0 %
4%
Atipy
OR
Drainage & Ablation 23,5 % 18,8 % Drainage
Cumulative Pregnancy rate ( 24 months )
Recurency rate
Maoris Panos and Brett Lincoln : Endometriotic Ovarian Cyst, the Case for Excisioned laparoscopic Surgery, Gynaecological Endoscopy, 2002, 11: 231-4