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Content
1.Anatomy of skin Introduction Skin layers epidermis, dermis, hypodermis 2.Function of skin Protection Immune Thermoregulation Metabolism Communication 3.Factors altering skin characteristics
Anatomy of skin
1. Human skin is divided into two layers a. epidermis (outermost) b. dermis ( innermost) 2. separated by basement membrane (BM) 3. A layer of loose connective tissue beneath the dermis called hypodermis, or subcutis
Skin layers
1. Epidermis stratum corneum stratum lucidum stratum granulosum stratum spinosum stratum basale (germinativum) 2. Basement membrane 3. Dermis papillary dermis reticular dermis 4. Hypodermis
Epidermis
1. the outermost layer 2. derived from ectoderm 3. relatively uniform in thickness (75~150 m, except soles and palms 0.4~0.6mm) 4. constantly being renewed (26~42 days) 5. divided into five layers.
Stratum Corneum
1. composed of dead keratinized cell (thin, stacked, pancake, anucleate cells) 2.abraded by daily trauma 3.80% are filled with keratin 4.Keratin -- hard in hair and nails soft in normal skin
Stratum Lucidum
1. in areas where the epidermis is thicker -- the palms, the soles 2. absent from thinner skin -- eyelid 3. one to five cells thick 4. a transitional layer where active lysosomal enzymes degrade the nucleus and organelles
Stratum Granulosum
1. one to five cells thick 2. keratohyalin granules present in the keratinocytes 3. contain profilaggrin, intermediate keratin filaments, loricrin help to organize the keratin filaments 4. intensely stained by acid and basic dyes 5. still have active nuclei
Stratum Spinosum
1. decribed as the prickly layer due to morphology (polyhedral) 2. prominent feature desmosome, a type of cell-cell junction 3. Synthesize involucrin a soluble precursor of cornified envelopes
Stratum Basale
1. the innermost epidermal layer 2. a single layer of mitotically active cells called basal keratinocytes or basal cells 3. upward migration can take 2~3 weeks
Dermis (corium)
1. The thickest layer of skin ( 2 ~ 4 mm, average 2 mm), the back is most thick 2. derived from mesoderm 3. vascularized and innervated. 4. a network of papillary loops, supported by a deep horizontal plexus 5. major proteins: collagen, elastin 6. divided into papillary dermis and reticular dermis
Hypodermis
1. a superficial fascia below the dermis 2. an adipose layer containing subdermal plexus of blood vessels 3. provide insulation, reserve of energy, cushioning 4. Werners syndrome, Scleroderma lack this layer