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FLORJAT- 30
Montajat- The First Company in the World to Formulate Florjat- 30 Do a Complete Pharmacokinetic Profile
Papers Accepted for Publication in International Journals e.g. JVPT, and AJVR
Product Sales Turnover- More than USD 1 Million in 2006 Drug of Choice for Salmonella, Pasteurella and E. coli
FLORJAT- 30
Primarily for Poultry Birds (Can be Effectively Used in Mammalian Neonatal Scour) The Latest 3rd Generation Broad- Spectrum Antibacterial Agent Exclusively for Veterinary Use Primarily Bacteriostatic Agent (Bactericidal at higher dosage) Binds to 50s Ribosome, Thus Arresting Protein Synthesis Contains Fluorine Atom- Prevents Plasmid Mediated Resistance Lacks a Nitro Group- Does Not Cause Aplastic Anemia in Humans No Bone Marrow Suppression (Not Reported)
FLORJAT- 30
PHARMACOKINETIC PATH
10.0
1.0
Observed Predicted
0.1 0 5 10 A 15 20 25
Semi- logarthimic Plasma Concentration time profile of Florjat- 30 following single dose (30 mg.kg-1) oral administration in poultry
FLORJAT- 30
PHARMACOKINETIC PARAMETERSParameters Units I II Animal No. III IV V VI MeanSE
Ka Ke t1/2 Ka
h-1 h-1 h
t1/2 Ke
AUC CL/F Tmax Cmax Vd/F
h
g.mL-1.h mL.kg-1.h-1 h g.mL-1 L.kg-1
6.34
90.77 0.33 1.88 8.129 3.03
4.93
82.05 0.36 1.50 9.26 2.32
10.564
116.82 0.25 2.09 6.68 3.59
4.785
113.37 0.26 2.45 11.18 1.83
10.018
122.28 0.24 1.34 7.62 3.57
5.682
85.57 0.35 1.45 8.72 2.87
7.051.05
101.817.19 0.290.02 1.780.17 8.590.63 2.860.28
Conclusion: The time for plasma concentration above 1 g/ml is more than 24 hours. Therefore, Florjat- 30 should be given at a dosage of 30mg/kg to be repeated every 24 hours following oral administration.
FLORJAT- 30
WITHDRAWAL PERIODSl No. Organ
24 hrs 1. 2. 3. 4. 5. Liver Heart Intestine Spleen Lung 0.0340.002 0.0940.005 0.0260.003 0.1340.005 ND
Conc. (mcg/g)
72 hr ND 0.050.006 0.0480.030 0.0790.003 ND 96 hrs ND ND ND ND ND
6.
7. ND not detectable
kidney
Muscles
ND
ND
ND
ND
ND
ND
Tissue concentration (g/g) of Florjat- 30 oral solution following multiple (5) dose (30 mg/kg) oral administration in poultry
FLORJAT- 30
LD 50, IM (Poultry Birds)S.No . 1 2 Group I II Dose(mg.kg-1) 1250 1275 Log dose 3.097 3.106 Dead 0/4 1/4 Dead % 0 25 Corrected 6.25 25 Probit 3.46 4.33
3 4
5 6
III IV
V VI
1300 1325
1350 1375
3.114 3.122
3.130 3.138
1/4 2/4
3/4 4/4
25 50
75 100
25 50
75 93.75
4.33 5.00
5.67 6.57
FLORJAT- 30
96%
Florjat 30%
Micojat- L
MICOJAT
Latest Mycoplasmicidal Drug- Tilmicosin
MICOJAT
The MIC requirement for Mycoplasma gallisepticum is 0.0125 g/ml. From the above graphs, it is evident that Tilmicosin is highly effective in treating or preventing Mycoplasma at the recommended dosage (Jordan and Horrocks, 1996)
Medication Program
Treatment after vaccination
Treatment*
Day
1-3
23-25
32
35
Vaccination
Lesion score
% Mortality
*Day 1-3 Micojat, Erythromycin, Tylosin and Enrofloxacin Day 23,24,25 Micojat, Erythromycin, Tylosin and Enrofloxacin
* Fax report
* Fax report
* Fax report
MICOJAT
RECOMMENDED USAGE 15-20 mg/kg body weight 3ml MICOJAT per 10 liter of drinking water Preventive Schedule Days 1,2 3 Days 24, 25, 26 (Days 20, 21, 22 for grow- outs @ Day 35) Better results along with Florjat 30 (given on Days 13, 14, 15)
PACK AVAILABLE120ml
PRODUCT
COMPOSITION ACARICIDE
INDICATIONS
ADMINISTRATION
PACKING
DIAZIN 600
Diazinon 600mg/ ml EC
250ml, 1000ml
COLIJAT WSP GEDOJAT WSP NEOJAT WSP NEOSIN WSP RYTHROCOL WSP
Colistin sulphate 10MIU/ gm Gentamicin 100mg, Doxycycline 100mg/ g Neomycin (as sulphate) 100% w/w Tylosin 700mg, Neomycin 300 mg Erythromycin 200mg, Colistin 500,000IU/ gm Lincomycin 333 mg; Spectinomycin 667mg/ 1.5gm
Salmonellosis and Colibacillosis All bacterial infections and Mycoplasmosis All gram -ve bacterial infections All bacterial infections and Mycoplasmosis All bacterial infections
Oral; 1g/ 20 liters. Oral; 1g/ 2 liters, sid 230g/ MT feed Oral; 1g/ 2 liters, sid Oral; 1g/ 4ltrs, sid
SPECTOLIN WSP
150gm
NICLOX liq.
1ltr
Coccidiosis Coccidiosis
Organic acids, Fe, Live yeast, Prebiotics (MOS) Bromhexine hydrochloride BP 15mg; Chlorpheniramine Maleate BP 10mg; Mint Extract/ ml NaCl 124g, Trisodium citrate dihydrate 103g, KCl 52g, Vitamin C 120g, Glucose qs/ kg Methenamine 950mg, Vit B1 8 mg, Vit B2 1mg, Vit K3 2mg/ gm Vitamin E 20g, Selenium 360mg/ ltr
Toxin Binder, Acidifier, Probiotic, Prebiotic Mucolytic expectorant; bronchodialator; anti- histaminic agent Electrolyte Anti-Heat Stress
1Ltr 1Ltr
Oral; 4.5gm/ltr
100gm, 1kg
1kg 1Ltr
BK-CHOLJAT MONTA- C
Vit.B1 10 mg, Vit.B2 4.5mg, Vit.B6 10mg, Vit.B12 5g, Vit.PP 50mg, Vit.K3 10mg, Choline 50mg, Ca- D Pantothenate 50mg, Folic acid 2mg/g Vitamin C 100% w/w
Laying performance
1 kg
Stress, Immunomodulation
1kg
MONTA- K
MONTA.3 liq.
Coccidiosis, cannibalism
Supplement, Heat stress
1kg
1Ltr
MONVIT- L liq.
Oral; 1ml/ltr
1Ltr
PRODUCT
INDICATIONS
ADMINISTRATION
PACKING
AFLABOND CHOLJAT DICLACOX FLAVOJAT L- LYSINE MADURAJAT MONENCOX PELCON PHYTOPHOS PROBAC- BMD ROBECOX SALINOCOX ZINBAC
HSCAS with organic acids Choline chloride 50% and 60% Diclazuril 0.5% granular Flavomycin 8% granular L- Lysine HCl source Maduramicin ammonium 1% granular Monensin 20 % granular Silicate based compounds Phytase 5000 FTU/ g Bacitracin Methylene Disalicylate 10% granular Robenidine 6.66% granular Salinomycin Sodium 12% granular Zinc Bacitracin 10% granular
Toxin Binder, Mold Inhibitor, and Mold Killer Enhanced Laying Performance Coccidiosis Prevention Non- absorbable Antibiotic Growth Promoter Lysine supplementation Coccidiosis Prevention Coccidiosis Prevention Pellet Binder (silicate based; non- lignin) Phosphorus supplementation Growth Promoter, Necrotic enteritis Coccidiosis Prevention Coccidiosis Prevention Non- absorbable Antibiotic Growth Promoter
500g/ MT feed As required 200g/ MT feed 100g/ MT feed As required 500g/ MT feed 450- 550g/ MT 2kg/ MT 100g/ MT feed 200g/ MT feed 450- 550g/ MT 500g/ MT feed 500g/ MT feed
25kgs 25kgs 25kgs 25kgs 25kgs 25kgs 25kgs 25kgs 25kgs 25kgs 25kgs 25kgs 25kgs
Thanks
Dr. Puneet Agrawal Marketing Manager
2nd Industrial City, Dammam 31491, Kingdom of Saudi Arabia Tel: +966- 812 3221, Fax: +966- 812 3112, e- mail: info@montajat.biz Web: www.montajat.biz