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Chapter 3
Dominic is a one week old boy. He was brought to the hospital with two day history of fever and lethargy. He was not able to breastfeed at all today.
2.
3. 4. 5. 6. 7.
Differential diagnoses
Main diagnosis
Triage
Emergency signs (Ref. p. 2,6) Obstructed breathing Severe respiratory distress Central cyanosis Signs of shock Coma Convulsions Severe dehydration Priority signs (Ref. p. 3) Tiny baby Temperature Trauma Pallor Poisoning Pain (severe) Respiratory distress Restless, irritable, lethargic Referral Malnutrition Oedema of both feet Burns
Emergency treatment
Airway management? OK Oxygen
Not respiratory distress, butslow breathing, periods of apnoea
Intravenous fluids
Unable to feed, prevention of hypoglycaemia
Immediate investigations?
Blood sugar
Place the prongs just inside the nostrils and secure with tape. (Ref. Chart 5, p. 11 p. 312-315)
Use an 8 F size tube Measure the distance from the side of the nostril to the inner eyebrow margin with the catheter Insert the catheter to this depth and secure it with tape
History
Domionic was delivered at term at home by a village birth attendant. He cried immediately. His cord was tied with a shoelace and then cut with a knife. He passed meconium within 24 hours of delivery. He was breast-feeding well until two days ago, after which he developed fever and lethargy (drowsiness). This morning he stopped sucking on the breast. He is not immunised yet. He is not from a malarial area.
His mother Sarah did not attend any antenatal clinics during her pregnancy and she did not receive tetanus toxoid. The pregnancy period was uneventful. There is no history of premature rupture of membrane.
Examination
Dominic was lethargic, ill-looking, and had soft grunting respiration.
Cardiovascular: both heart sounds were audible and there was no murmur
Abdominal examination: soft, bowel sound was present; liver was 2 cm below the right costal margin Ears-Nose-Throat: mouth: slightly dry, no oral thrush; ears: clear, no discharge Neurology: lethargic; no neck stiffness; fontanelle normal
Skin: no rash
Differential diagnoses
List possible causes of the illness Main diagnosis Secondary diagnoses Use references to support diagnoses: neonate with lethargy (Ref. p. 25)
Differential diagnoses
Birth asphyxia
(Ref. p. 25)
Meningitis
Sepsis
Investigations
Blood glucose Haemoglobin
Blood sugar:
Urine
Urine routine: - Chemistry/Protein/ Glucose: - Nitrate / Leucocyte esterase: - Blood: nil nil nil
Microscopy:
- Red Blood Cells: 0 x 106/l (<13) - Leucocytes: 0 x 106/l
Culture: - No growth
Diagnosis
Summary of findings: Examination: hypothermia, lethargic, slow breathing, some apnoea, soft grunting respirations Blood examination shows moderate neutrophilia with moderate left shift and thrombocytopenia No localizing signs of infections Blood culture pending
Sepsis
Treatment
IM / IV antibiotics for 10 days (Ref. p. 55):
Ampicillin (or penicillin) and gentamicin
(Ref. p. 69-72)
If Staphylococcal aureus suspected (skin pustules, umbilical infection, boils, septic arthritis) administer Cloxacillin instead of ampicillin/penicillin
If not improving in 2-3 days the antibiotic treatment may need to be changed
Supportive Care
Fluid management (Ref. p. 57) Maintain a stable thermal environment (Ref. p. 56) Pay strict attention to hand washing
Monitoring
Monitor response to treatments and look for complications Monitor: Oxygen saturation Apnoea monitoring if possible Vital signs Treatments given Feeding/nutrition given Blood glucose Observe the baby frequently and use a Monitoring chart (Ref. p. 320, 413)
Summary
Neonate with sepsis Symptoms and signs are often non-specific Neonates with any common serious problem can develop: apnoea, bradycardia, jaundice, lethargy, poor feeding Good history and examination are very important Antibiotics, oxygen, prevention of hypothermia and hypoglycaemia, breast milk are good general treatments for most seriously ill neonates Importance of frequent monitoring