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HISTORY
1958 Senning and Elmqvist Asynchronous (VVI) pacemaker implanted by thoracotomy and functioned for 3 hours Arne Larsson First pacemaker patient Used 23 pulse generators and 5 electrode systems Died 2001 at age 86 of cancer 1960 First atrial triggered pacemaker 1964 First on demand pacemaker (DVI) 1977 First atrial and ventricular demand pacing (DDD) 1981 Rate responsive pacing by QT interval, respiration, and movement 1994 Cardiac resynchronization pacing
What is a Pacemaker?
Body tissue
Cathode
S
Battery
Anatomy of a Pacemaker
Resistors Atrial connector Connector
Ventricular connector
Defibrillation protection Output capacitors
Hybrid
Clock
Reed (Magnet) switch Telemetry antenna
Battery
Power source
Longevity in single chamber pacemaker is 7 to 12 years. For dual chamber longevity is 6 to 10 years. Most pacemakers generate 2.8 v in the beginning of life which becomes 2.1 to 2.4 v towards end of life.
9
Leads
Deliver electrical impulses from the pulse generator to the heart
Lead
Lead Characterization
Position within the heart
Endocardial or transvenous leads Epicardial leads
Polarity
Unipolar Bipolar
Fixation mechanism
Active/Screw-in Passive/Tined
Insulator
Silicone Polyurethane
Shape
Straight J-shaped used in the atrium
Lead components
Conductor Connector Pin Insulation Electrode
Passive fixation
The tines become lodged in the trabeculae
Active Fixation
The helix (or screw) extends into the endocardial tissue Allows for lead positioning anywhere in the hearts chamber
Active Fixation
Advantages
Passive Fixation
Easy fixation Less expensive & simple Easy to reposition Minimal trauma to patient Lower rate of dislodgement Lower thresholds Removability
Disadvantages
Cathode
+
Anode
Cathode
Flows through the tip electrode located at the end of the lead wire
Stimulates the heart Returns to the ring electrode above the lead tip
Anode
Cathode
Unipolar leads
One electrode on the tip & one conductor coil
Conductor coil may consist of multiple strands - (multifilar leads) Unipolar leads have a smaller diameter than bipolar leads Unipolar leads exhibit larger pacing artifacts on the surface ECG
Bipolar leads
Circuit is tip electrode to ring electrode Two conductor coils (one inside the other) Inner layer of insulation Bipolar leads are typically thicker than unipolar leads Bipolar leads are less susceptible to oversensing noncardiac signals (myopotentials and EMI)
Unipolar
Advantages Smaller diameter Easier to implant Large spike
Bipolar
No pocket stimulation Less susceptible to EMI Programming flexibility
Larger diameter Stiffer lead body Small spike Higher impedance Voltage threshold is 30% higher
Electrodes
Leads have 1/> electrically active surfaces referred to as the electrodes Deliver an electrical stimulus, detect intrinsic cardiac electrical activity, or both Electrode performance can be affected by
Materials Polarization Impedance Pacing thresholds Steroids
Electrode Materials
The ideal material for an electrode
Porous (allows tissue ingrowth) Should not corrode or degrade Small in size but have large surface area Common materials
Platinum and alloys (titanium-coated platinum iridium) Vitreous carbon (pyrolytic carbon) Stainless steel alloys such as Elgiloy
Voltage is the force that causes electrons to move through a circuit In a pacing system, voltage is:
Measured in volts Represented by the letter V Provided by the pacemaker battery Referred to as amplitude
Voltage
Current
The flow of electrons in a completed circuit In a pacing system, current is:
Measured in mA (milliamps) Represented by the letter I Determined by the amount of electrons that move through a circuit
Constant-Voltage and Constant-Current Pacing Most permanent pacemakers are constantvoltage pacemakers Voltage and Current Threshold
Pacing Thresholds
Defined as the minimum amount of electrical energy required to consistently cause a cardiac depolarization
Capture
Non-Capture
Capture
.50 .25 0.5 1.0 1.5
Energy (J) = Voltage (V) Current (mA) Pulse Duration (PD in ms). Charge (C) = Current (mA) Pulse Duration (ms).
At very low pulse width thresholds, the charge is low, but the energy requirements are high because of elevated current and voltage stimulation thresholds. At pulse durations of 0.40.6 ms, all threshold parameters - ideal At high pulse durations, the voltage and current requirements may be low, but the energy and charge values are unacceptable
Impedance
The opposition to current flow
In a pacing system, impedance is Measured in ohms Represented by the letter R (W for numerical values) The measurement of the sum of all resistance to the flow of current
Resistance is a term used to refer to simple electric circuits without capacitors and with constant voltage and current Impedance is a term used to describe more complex circuits with capacitors and with varying voltage and current
Impedance
Pacing lead impedance typically stated in broad ranges, i.e. 300 to 1500 Factors that can influence impedance
Resistance of the conductor coils Tissue between anode and cathode The electrode/myocardial interface Size of the electrodes surface area Size and shape of the tip electrode
V
V=IXR I=V/R R=V/I
Sensing
Sensing is the ability of the pacemaker to detect an intrinsic depolarization
Pacemakers sense cardiac depolarization by measuring changes in electrical potential of myocardial cells between the anode and cathode
An Electrogram (EGM) is the Recording of Cardiac Waveforms Taken From Within the Heart
Intrinsic deflection on an EGM occurs when a depolarization wave passes directly under the electrodes Two characteristics of the EGM are:
Signal amplitude(mv) Slew rate(v/sec)
The Intrinsic R wave amplitude is usually much greater than the T wave amplitude
Undersensing . . .
Pacemaker does not see the intrinsic beat, and therefore does not respond appropriately
VVI / 60
Oversensing
...though no activity is present
VVI / 60
V: Ventricle A: Atrium
V: Ventricle A: Atrium
D: Dual (A+V) D: Dual (A+V) D: Dual (T+I) C: Communicating O: None O: None O: None
S: Single
(A or V)
S: Single
(A or V)
Pacemaker Timing
Pacing Cycle : Time between two consecutive events in the ventricles (ventricular only pacing) or the atria (dual chamber pacing) Timing Interval : Any portion of the Pacing Cycle that is significant to pacemaker operation e.g. AV Interval, Ventricular Refractory period