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ANEMIA
lungs
Hb + O2 HbO2
tissues
HEMOGLOBIN
Hemoglobin consists of four protein
chains.
Each chain is
conjugated with a
β α nonprotein moiety
called the heme
group, which binds
oxygen to a ferrous
α β ion
(Fe2) at its center
Hypoxemia RBC PRODUCTION AND
(inadequate O2 transport REGULATION
↓ proliferation
By external agents, physical
or chemical (e.g. ionizing
radiation, marrow toxins
Marrow
damage Hereditary or acquired
or defect aplastic anemia
Maturation
defect
Iron deficiency and the
anemia of chronic disease
Microcytic
Impaired globin chain
(hypochromic synthesis
(thalassemias)
Impaired porphyrin
synthesis
ANEMIA Membrane defects (e.g.
hereditary
Phagocytosis by spherocytosis)
reticuloendothelial
cells Heinz body associate
(e.g. G6PD deficiency)
Hemoglobin discorders
(e.g. sickle cell)
Accelerated Red cell
fragmentation DIC
Hemolysis
syndromes Vasculitis
syndromes
Sickle cell
NORMAL SC TRAIT
A S A A A S A A
A S A A S S S A
• Ulcers on the Legs. Sickle cell ulcers (sores) usually begin as small,
raised, crusted sores on the lower third of the leg. Leg sores occur more
often in males than in females and usually appear between the ages of
10 and 50. The cause of leg ulcers is not clear. The number of ulcers can
vary from one to many. Some heal rapidly, but others persist for years or
come back after healing.
Weakness Slowed
and physical Damage Damge Damage Brain Damage
lassitude development to heart to lungs to damage to abd Kidney
muscle muscles organs damage
Impaired and
mental joints
function
Heart pneumonia paralysis Kidney
Abd
Failure Rheumatism pain failure
DEATH
Who Is At Risk for Sickle Cell Anemia?