Documenti di Didattica
Documenti di Professioni
Documenti di Cultura
25/04/12
REGENERATION OF NERVE
Keterkaitan dengan kepentingan (calon) sarjana kedokteran (Sked) dan dokter (dr)
Memahami & menjelaskan regenerasi sistem saraf
25/04/12
REGENERATION OF NERVE
MULTIPLE SCLEROSIS
also known as "disseminated sclerosis" or "encephalomyelitis disseminata", is an inflammatory disease in which the fatty myelin sheaths around the axons of the brain and spinal cord are damaged, leading to demyelination and scarring as well as a broad spectrum of signs and symptoms.[1]
Disease onset usually occurs in young adults, and it is more common in women.[1] It has a prevalence that ranges between 2 and 150 per 100,000.[2] MS was first described in 1868 by Jean-Martin Charcot.[3]
25/04/12
REGENERATION OF NERVE
NEUROREGENERATION
Neuroregeneration refers to the regrowth or repair of nervous tissues, cells or cell products.
Such mechanisms may include generation of new neurons, glia, axons, myelin, or synapses. Neuroregeneration differs between the peripheral nervous system (PNS) and the central nervous system (CNS) by the functional mechanisms and especially the extent and speed.
25/04/12 REGENERATION OF NERVE 7
25/04/12
REGENERATION OF NERVE
25/04/12
REGENERATION OF NERVE
25/04/12
REGENERATION OF NERVE
25/04/12
REGENERATION OF NERVE
11
25/04/12
REGENERATION OF NERVE
12
25/04/12
REGENERATION OF NERVE
13
25/04/12
REGENERATION OF NERVE
25/04/12
REGENERATION OF NERVE
25/04/12
REGENERATION OF NERVE
16
In the CNS, there seem to be two "glial culprits" that inhibit axon regeneration.
These are oligodendrocytes and astrocytes. Both play key roles in CNS support and metabolism.
It is logical to ask hear, "why on earth would the body ever want to inhibit regenerative ability?" The body has a good answer.
25/04/12
REGENERATION OF NERVE
18
25/04/12
REGENERATION OF NERVE
25/04/12
REGENERATION OF NERVE
CLINICAL TREATMENTS
1. Surgery
2. Autologous nerve grafting
25/04/12
REGENERATION OF NERVE
21
Methylprednisolon
Sygen
Guidance Channels
Stem Cells Growth Factors Gene Therapy
25/04/12
REGENERATION OF NERVE
23
25/04/12
REGENERATION OF NERVE
25/04/12
REGENERATION OF NERVE
25
25/04/12
REGENERATION OF NERVE
26
25/04/12
REGENERATION OF NERVE
27
25/04/12
REGENERATION OF NERVE
28
25/04/12
REGENERATION OF NERVE
29
25/04/12
REGENERATION OF NERVE
30
25/04/12
REGENERATION OF NERVE
31
Conclusion: A century of research focussed on the lesion site has been unproductive. An alternative field of research must be developed and the best candidate is the undamaged CNS.
REGENERATION OF NERVE 32
25/04/12
Source: MRC Centre for Stem Cell Biology and Regenerative Medicine & Cambridge Centre for Brain Repair & Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, UK.
REGENERATION OF NERVE 33
25/04/12
Abstract
Remyelination is a regenerative process in the central nervous system (CNS) that produces new myelin sheaths from adult stem cells. The decline in remyelination that occurs with advancing age poses a significant barrier to therapy in the CNS, particularly for long-term demyelinating diseases such as multiple sclerosis (MS). Here we show that remyelination of experimentally induced demyelination is enhanced in old mice exposed to a youthful systemic milieu through heterochronic parabiosis. Restored remyelination in old animals involves recruitment to the repairing lesions of blood-derived monocytes from the young parabiotic partner, and preventing this recruitment partially inhibits rejuvenation of remyelination. These data suggest that enhanced remyelinating activity requires both youthful monocytes and other factors, and that remyelination-enhancing therapies targeting endogenous cells can be effective throughout life.
REGENERATION OF NERVE 34
25/04/12
The ability to regenerate nerve cells in the body could reduce the effects of trauma and disease in a dramatic way. In two presentations at the NSTI Nanotech 2007 Conference, researchers describe the use of nanotechnology to enhance the regeneration of nerve cells. In the first method, developed at the University of Miami, researchers show how magnetic nanoparticles (MNPs) may be used to create mechanical tension that stimulates the growth and elongation of axons of the central nervous system neurons. The second method from the University of California, Berkeley uses aligned nanofibers containing one or more growth factors to provide a bioactive matrix where nerve cells can regrow.
ACCELERATED NERVE REGENERATION IN MICE BY UPREGULATED EXPRESSION OF INTERLEUKIN (IL) 6 AND IL-6 RECEPTOR AFTER TRAUMA
25/04/12
REGENERATION OF NERVE