Intransitive verb \-miks\: to isolate target analyte from a biospecimen rapidly and efficiently for health related information

How valuable is time and information for our health care?

Team members
L. Andrew Lee, Ph.D. Operations William E. Brewer, Ph.D. Analytical Chemistry Qian Wang, Ph.D. Chemical Biology and Biomaterials

Clinical Diagnostics:
Services that help doctors implement personalized treatment
U.S. diagnostic labs recorded $47 bln in revenue (2011) Growing 6.7% annually for last 10 years (2000 2010) Medicare payments to independent lab testing > $2.54 bln (2006) Lab Industry = 2.3% of Total National Health Care Expenditure PUSHING Lab Industry to $98.4 bln by 2017!!!*
*Source: CMS: National Health Care Expenditures Projections: 2007-2017 and Washington G-2 Reports estimates

More time and accurate information means saving lives and costs

The diagnosis starts here

Sick OR Healthy <IMCS MARKET>

Doctors office

Clinical Lab (CLIA-certified)

More time and accurate information means saving lives and costs

How many samples?

80 mln/yr in 2011
Annual global test volumes from 2007 to 2011 for vitamin D with DiaSorin RIA tests as global market leader

>220K per day for just one target!!!

*Source: Vitamin D and Diasorin

More time and accurate information means saving lives and costs

Diagnosis Output

beyond fast

BOTTLENECK: 80 mln per yr = 220,000 per day

Fastest machine (LC-MS/MS) processes 200 to 300 samples per day and costs $250,000. IMCS launches iSEP affinity tips to work with latest technologies* to process 1536 samples in 2.56 hrs
More time and accurate information means saving lives and costs

BILLION

ADVANTAGE
UNIQUE OPPORTUNITY

PIPETTE TIPS USED IN ALL LIQUID HANDLING BIO-SPECIMENS ALL LIQUID FORMATS ORAL FLUID, BLOOD, URINE (complex solutions) More time and accurate information means saving lives and costs

ADVANTAGE
Current Method Pipette Extraction

Involves two step process (sample transferred using pipette to column). More solvent use = higher cost

Easily automated, well accepted, user friendly, more consistent results and more environmentally friendly

More time and accurate information means saving lives and costs

Current Products
Application iSEP-100
iSEP-WAX100 iSEP-RP100

Table 2. Products and Development Pipeline (2013)

Global Market Size $17.2 bln (2017E) CAGR 14.2% 312 mln tests (U.S.) 400 mln (Europe) CAGR 33.5%* $1.5 bln (2011) CAGR 18.5%+ $341.7 mln (2010) CAGR 5-7%# Major Players Thermo-Fisher, Agilent, Life Technologies, Sigma, Roche Quest, LabCorp, Diasorin, Abbott, Roche

Proteomics, Drug Delivery Screening Vitamin D2/D3 (Bone disorders, hypertension)

iSEP-VDA (Early phase) iSEP-DNA (Early phase) iSEP-Affinity

384 format

Genomic DNA isolation for molecular diagnostics

Esoteric Lab Diagnostics, Target specific drug screen

Qiagen, Life Technologies, Roche, Illumina, ABI, Agilent

Thermo-Fisher, Agilent, Life Technologies, Sigma, Roche

Time and information for healthcare mean saving lives and costs

Current Focus
Table 3. Current Global Market Opportunities (2013)
Region Southern California (Biotech Beach) Southwest (Arizona, Texas) Northeast U.S. (Boston, Philadelphia) Market Entry Joint project collaborations, CLIA-certified laboratories CLIA-certified laboratories, biopharmaceutical companies Biopharmaceutical and pharma (antibody drug conjugates) Product Entry iSEP-100 WAX, RP iSEP-Affinity iSEP-100 WAX, RP iSEP-Affinity iSEP-100 WAX, RP iSEP-Affinity

Overseas (China, S. Korea)

Agriculture (livestock feed, fruits DPX products and iSEP & vegetables) series

Time and information for healthcare mean saving lives and costs

Our next steps

Pharmaceutical Companies: Bio-distribution Pharmaco-kinetics Forensic Toxicology: Cause of death (toxin screen) Tissue distribution

Point of Care Devices: Transitioning role of diagnostics devices

Time and information for health care mean saving lives and costs