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Native
Hybrid
S E L E C T I V E breeding
Blending in Parakeet:
Yellow x Green = Blue?
Several shades!!!
inheritance as the blending of characteristics was incorrect No one studied the problem systematically until Gregor Mendel (1822-1884)
What is a gene?
A gene is a stretch of DNA whose sequence determines the structure and function of a specific functional molecule (usually a protein)
DNA
GAATTCTAATCTCCCTCTC AACCCTACAGTCACCCATTT GGTATATTAAAGATGTGTTG TCTACTGTCTAGTATCC
Computer program
mRNA
Working copy
Protein
Specific function
Protein
mRNA
Mendels experiments
Mendels data
Meiosis
Sex cells: egg/sperm 4 d-cells Half of the number
Homologoue = pair of the same type of chromatids Diploid = paired state Haploid = unpaired
Meiosis in a Nutshell
Meiosis is a special type of cell division that occurs in sexually reproducing organisms. It reduces the chromosome number by half, enabling sexual recombination to occur.
It ensures that an organism has the same number of chromosomes in each generation.
Terminology
Haploid: containing one copy of each chromosome (n=23)
Sperm
B
Eggs
B BB Bb b Bb bb
Terminology Genotype: the states of the two alleles at one or more locus associated with a trait Phenotype: the state of the observable trait Genotype
BB (homozygous) Bb (heterozygous) bb (homozygous)
Phenotype
Brown eyes Brown eyes Blue eyes
BB Bb
Bb bb
2. Law of Dominance...
If your two alleles are different (heterozygous, e.g. Bb), the trait associated with only one of these will be visible (dominant) while the other will be hidden (recessive). E.g. B is dominant, b is recessive.
Sperm
B B
Eggs
b Bb bb
BB Bb
S/s
Y/y
SY
25%
Sy
25%
sY
25%
sy
25%
Segregation
S Y y y Recombinants s Y
Gametes
s S
B
BB Bb
b
Bb bb
Blue recessive:
bb
B
Eggs
B?
B?
B?
bb
bb
B? B?
First known person known to carry the disorder was Queen Victoria of England. Thus all those affected are related to European royalty.
Colour blindness is usually passed down from mother to son on the 23rd chromosome (X-linked)
Y-linked inheritance
baldness
Non-Mendelian: mtDNA
Mitochondrial DNA point mutations are maternally inherited and can occur in rRNA or tRNA genes, or in genes coding for proteins of respiratory chain complexes.
Non-Mendellian:
Gene interaction:
Many biological pathways are governed by multiple enzymes, involving multiple steps. If any one of these steps are altered. The end product of the pathway may be disrupted.
Environmental effects:
Sometimes genes will not be fully expressed owing to external factors. Example: Human height may not be fully expressed if individuals experience poor nutrition.
Summary
Mendel deduced three simple laws of inheritance:
Segregation Dominance Random assortment
The majority of traits dont follow these rules but Mendels laws are nevertheless crucial to understanding almost all genetic inheritance
Watch
http://highered.mcgrawhill.com/sites/0072495855/student_view0/ch apter2/animation__mitosis_and_cytokinesis.h tml
http://library.thinkquest.org/20465/games. html