IMMUNIZATION

Definition
 Immunization
– >is the process by which an individual's immune system
becomes fortified against an agent (known as the
immunogen).
– >When an immune system is exposed to molecules that
are foreign to the body (non-self), it will orchestrate an
immune response, but it can also develop the ability to
quickly respond to a subsequent encounter (through
immunological memory).
– >Immunization can be done through various
techniques, most commonly vaccination. Vaccines
against microorganisms that cause diseases can
prepare the body's immune system, thus helping to
fight or prevent an infection.
 Kinds of Immunization
 Natural Immunization
-> from the word itself “nature” meaning inborn. These
are the immunization that we get from our mother
while we we’re still in their womb.

 Artificial immunization
– > human strive to prolong their life and because of
the technology they arrived with what we call
vaccines.
 Forms of Immunization

 Passive and active immunization

-> Immunization can be achieved in an active or passive
fashion.
 Active Immunization
-> Active immunization entails the
introduction of a foreign molecule into the
body, which causes the body itself to
generate immunity against the target. This
immunity comes from the T cells and the B
cells with their antibodies.

-> Active immunization can occur naturally

when a person comes in contact with, for
example, a microbe. If the person has
come into contact with the microbe and
has pre-made antibodies for defense (like
in passive immunization) , the person
becomes immunized.
-> When an immune system is exposed to molecules that are
foreign to the body (non-self), it will orchestrate an immune
response, but it can also develop the ability to quickly
respond to a subsequent encounter (through immunological
memory). This is a function of the adaptive immune system.
Therefore, by exposing an animal to an immunogen in a
controlled way, their body can learn to protect itself: this is
called active immunization.

 The immune system will eventually create antibodies and

other defenses against the microbe. The next time, the
immune response against this microbe can be very efficient;
this is the case in many of the childhood infections that a
person only contracts once, but then is immune.

-> Artificial active immunization is where the microbe, or parts of

it, are injected into the person before they are able to take it
in naturally. If whole microbes are used, they are pre-treated.
Depending on the type of disease, this technique also works
with dead microbes, parts of the microbe, or treated toxins
from the microbe.
 Passive Immunization

-> Where pre-made elements of the immune

system are transferred to a person, and the body
doesn't have to create these elements itself.

-> Currently, antibodies can be used for passive

immunization. This method of immunization
begins to work very quickly, but it is short
lasting, because the antibodies are naturally
broken down, and if there are no B cells to
produce more antibodies, they will disappear.
-> Passive immunization can be naturally acquired
when antibodies are being transferred from
mother to fetus during pregnancy, to help protect
the fetus before and shortly after birth.

-> Artificial passive immunization

> normally given by injection and is used if
there has been a recent outbreak of a particular
disease or as an emergency treatment to poisons
(for example, for tetanus).
 Topic Overview
 What are immunizations?
> Immunizations help protect you or your child from disease.
They also help reduce the spread of disease to others and
prevent epidemics. Most are given as shots. They are
sometimes called vaccines, or vaccinations.

>In many cases when you get a vaccine, you get a tiny
amount of a weakened or dead form of the organism
that causes the disease. This amount is not enough to
give you the actual disease. But it is enough to cause
your immune system to make antibodies that can
recognize and attack the organism if you are ever
exposed to it.
 Why should you get immunized?

– Immunizations protect you or your child from

dangerous diseases.
– They help reduce the spread of disease to others.
– Getting immunized costs less than getting treated for
the diseases that the shots protect you from.
– Vaccines have very few serious side effects.
– They are often needed for entrance into school or day
care. And they may be needed for employment or for
travel to another country.

Note: If you are a woman who is planning to get pregnant,

talk to your doctor about what immunizations you have
had and what you may need to protect your baby.
 What are the side effects of vaccines?

• Most side effects from vaccines are minor, if they occur at

all. Your doctor will explain the reactions that could occur.
They may include:
– Redness, mild swelling, or soreness where the shot was
given.
– A slight fever
– Drowsiness, crankiness, and poor appetite in some babies.
– A mild rash 7 to 14 days after chickenpox or measles-
mumps-rubella shots.
– Temporary joint pain after a measles-mumps-rubella shot.
– Serious reactions, such as a fever over 104.5°F (40.3°C)
or trouble breathing. It is much more dangerous for a child
to risk getting the diseases than it is to risk having a
serious reaction to the vaccine.
 Va ccin e Do se Ro ute o f Sit e o f
Ad min istratio n Admin is tratio
n
BCG Infants 0.05 ml Intradermal (ID) Right deltoid
region of the
arm
DPT (Diphtheria, 0.5 ml Intramuscular Upper outer
Pertusis, portion of the
Tetanus) thigh
OPV (Oral Polio 2 drops or Oral Mouth
Vaccine) depending
on
manufactur
er’s
instructions

AMV (Anti 0.5 ml Subcutaneous Outer part of the

Measles upper arm
Vaccine)
Hepatitis B 0.5 ml Intramuscular Upper outer
portion of the
thigh
TT (Tetanus 0.5 ml Intramuscular Deltoid region of
Toxoid) the upper arm