Benign and malignant connective

tumors
Workshop 10
 Connective tumours
• They are tumours with origin in multipotent mesenchymal cells that can
differentiate and form differentiated connective tissues.
• Classification
– By evolution: benign and malignant
– By tissue origin:
Benign Connective Tumors Malignant Connective Tumors
+OMA +SARCOMA
Lipoma Liposarcoma
Chondroma Chondrosarcoma

Fibroma Fibrosarcoma
Osteoma Osteosarcoma
Hemangioma, limfangioma Angiosarcoma
 Microscopy
• Chondroma
• Capillary hemangioma -skin
• Cavernous Hemangioma - liver
• Moderate differentiated fibrosarcoma
• Well differentiated osteosarcoma
 Chondroma
• Benign tumor are formed by
hyaline cartilaginous tissue
• Microscopy
 Nodular, well
circumscribed and
encapsulated tumor
 Is composed by lobules of
mature hyaline cartilage
separated by connective
vascular axes with role of
support and nutrition
 The tumoral cartilage is
composed from basophilic
chartliagenous matrix
(chondrin) presenting
chondroplasts that contains
mature chondrocytes
Capillary hemangioma-skin

• A benign tumor formed from

numerous blood vessels.
• The tumor is located at the level of
superficial and profound dermis.
• Is formed by tumoral lobules that
contain numerous capillary vessels
connected by connective tissue
bands.
• The tumor has a lobular growth
that confers the infiltrative
character.
• The tumoral capillary vessels are
lined by a normal endothelium.
Some of them are unopened or
collapsed, the others are opened
containing blood.
•
 Cavernous hemangioma -
liver

• Is a benign tumour formed by

numerous vascular spaces, located
in the liver.
• The tumour is composed by
tumoral lobuli that contain many
large vascular spaces separated by
connective tissue.
• The vascular spaces have
different shapes and size, and are
lined by a normal endothelium
containing blood or thrombi.
• The tumour has lobular growth
that confers the infiltrative
character
 Moderate differentiated
fibrosarcoma

• Is a connective malignant tumour

resulting from proliferation of
fibroblasts.
• Microscopy
 The tumor has a hypercellular
feature, is composed from
fusiform atypical cells, disposed
in bundles, but with a reduce
production of collagen fibers.
 The tumoral cells are resembling
with fibroblasts, they have
moderate pleomorphism and a
greater number of mitoses than
differentiated fibrosarcoma.
 The tumoral stroma contains
sarcomatous vessels.
 Osteosarcoma
• Is a malignant tumour
that forms tumoral bone =
osteogenic sarcoma
• In the structure of the
tumour we can put in
evidence:
 Areas of fusiform
non-differentiated
cells of sarcomatous
type.
 Strands of osteoid
tissue
 The osseous lamellae
containing atypical
cells
 The tumor contains
sarcomatous vessels,
necrosis and
hemorrhage
Osteosarcoma