Summary of the December 15, 2015 issue, including articles on lactation and incident diabetes after pregnancy with gestational diabetes, direct-acting antiviral treatment of hepatitis C virus infection, nucleoside reverse transcriptase inhibitors and HIV infection, bladder cancer, and radial versus femoral access in acute coronary syndromes, as well as a discussion about the American College of Physicians (ACP) at the close of its centennial year, a Beyond the Guidelines grand rounds discussion on HIV preexposure prophylaxis, and an ACP position paper on the patient care implications of "concierge" and other direct patient contracting practices.