In 1672, mysterious poisons were found in the home of a recently deceased Frenchman. This discovery would eventually lead to a years-long murder scandal that would come to be known as 'The Affair of the Poisons', and before it done even those in the noble class would be accused of devil worship, human sacrifice, treason, murder and more. In this first part, Mme de Brinvilliers' murder of her father and brothers by poison will be explored, as this was the case that started it all. Also, explored in this episode, in relation to the world view and time period, is alchemy, the philosopher's stone, and the lives of Sir Issac Newton and Nicolas Flamel.