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Foreword
D
iversity is vital for life. Tis simple phrase lies at the heart of what both Natoora and I do. We approach our work from different directions, but our conclu-sions are identical. Our planet is host to an incredibly complex set of ecosystems that are known as biomes. Life has evolved amidst vast diversity on both the macro and micro scales, from the innumerable microorganisms that first ignited evolution to the incredible abundance of organisms and ecosystems that comprise Earth. All animals originally evolved from simple microorganisms.  Tese single-celled creatures also evolved alongside us and depended on us for food and shelter. But today, these rela-tionships that have underpinned life on Earth across aeons are being ripped apart. Te intricate webs that bind species together are slowly being degraded. If these webs fail (a real possibility if we continue on our current course), the damage to our health and the health of the planet will be irreparable.Modern agriculture is stripping our soil of nutrients and microbes; the food industry is stripping our food of its nutrient density; and the Western diet is stripping our own ecosystem, our gut microbiome, of its diversity. Tese losses of diversity mean that our combined future is on the line.
 
 In Search of the Perfect Peach
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Much of my research now focuses on the gut microbiome – the trillions of microorganisms that live in our gut. Just a few decades ago, we thought these microbes helped us to digest food, gave us food poisoning and did little else of interest.Now, we know so much more. Te links between the gut microbiome and almost any health condition you can think of are clear. Tis is because gut bacteria heavily influence our immune system by ‘training’ it, regulating inflammation and allergies, reducing ageing and cancer, and ensuring we can thrive. Tey even play key roles in our mood and mental health. A key measure of the health status of the gut microbiome is diversity. Te Hadza people in anzania have some of the most diverse gut microbiomes on the planet and the fewest diseases. I  was lucky to spend some time with these wonderful people. After  just three days following their hunter-gatherer lifestyle, my gut microbial diversity increased by an incredible 20 per cent.  Te foods I ate and the way they were grown no doubt had a huge influence, but the act of foraging itself and being exposed to microbes in the environment was equally important. In the  Western world, there is far too much focus on sterility: we have created environments that are rich in plastics, pesticides and other chemicals that we expose ourselves to through our skin and lungs, especially in cities. No longer do we live in harmony  with the natural world and all its wonderfully diverse microbial forms of life. Only around 1 per cent of bacteria cause disease,  while the rest are safe or actively beneficial. Sadly, just a few days after my anzanian experience, my microbiome returned to baseline. Tis demonstrates both the incredible flexibility of the gut microbiome and its sensitiv-ity to environmental and dietary changes. In the Western  world, diversity is declining. As there is on a macro level on our planet, there is a mass extinction event going on in our
 
Foreword 
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guts, with an estimated 50 per cent of microbe species now permanently lost.  What can we do about this? Seven years ago, I co-founded ZOE, a science and nutrition company. Te programme includes a gut microbiome test and we guide our members through healthy, daily dietary choices suited to their metabo-lism. We now offer a repeat gut microbiome test after a few months. Tis data shows without a doubt that a diverse, plant-based diet with limited ultra-processed foods (UPFs) improves the gut microbiome. We see a reduction in ‘bad’ species related to poor health outcomes like obesity, heart disease and inflam-mation and a marked increase in ‘good’ species associated with improved health.Faced with the meteoric rise in diet-related diseases like cancer and type 2 diabetes, we aim to improve the health of mil-lions. However, we have a battle on our hands. Big Food holds all the cards. Te sharp rise in UPF (fake food) consumption is deeply worrying. In the United States and United Kingdom, 60 per cent of adults’ calories are consumed via these edible food-like substances and over 70 per cent of children’s. Fake foods rarely contain fibre, which our gut bacteria rely on. Tey do contain sugar, unhealthy fats and a vast array of chemicals, like sweeteners and emulsifiers. Additives, colourants, artificial flavourings and the like have all been tested for safety. But many of these tests were conducted decades ago on rodents and checked individual chemicals, not the cocktails found in our food. Tey also mostly focused on cancer.Studies looking at the impact of these chemicals on gut health are rare. And the food industry, of course, has no interest in investigating their additives any further than the law requires, nor are they obligated to do so. Te reality is that no one knows  what happens when you consume complex cocktails of these
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