RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES KARNATAKA, BANGALORE

COMPLETED PROFORMA FOR REGISTRATION OF SUBJECT FOR DISSERTATION

COMPARATIVE STUDY OF JATYADI TAILA AND

KARANJADI TAILA IN DUSHTAVRANA

By Dr K.P SREEJITH M.S. SCHOLAR Dept.of PG studies in Shalyatantra SDM College of Ayurveda Udupi

GUIDE Dr.K. R.RAMACHANDRA BSc.MD(AYU) PROFESSOR AND HOD DEPT OF STUDIES IN SHALYATANTRA SDM COLLEGE OF AYURVEDA, UDUPI CO - GUIDE Dr.JAYAKRISHNA NAYAK MS (AYU) LECTURER DEPT OF STUDIES IN SHALYATANTRA SDM COLLEGE OF AYURVEDA, UDUPI

2008 2009 SDM College of Ayurveda Kuthpady, Udupi

From Dr.K.P Sreejith 1

1st yr. M.S. Scholar Dept of P.G Studies in Shalyatantra S.D.M College of Ayurveda, Kuthpady, Udupi -574118 To The Registrar, Rajiv Gandhi University of Health Sciences Bangalore, Karnataka. Through The Principal & Head Of The Department Shalyatantra S.D.M College of Ayurveda, Kuthpady, Udupi- 574118

SUBJECT: Submission of completed proforma for the registration of synopsis for dissertation. Respected sir, I request you to kindly register the below mentioned subject against my name for the submission of dissertation to, The Rajiv Gandhi University of Health Sciences Bangalore, for the partial fulfillment of M S (Ayu) in Shalyatantra. TITLE OF DISSERTATION COMPARITIVE STUDY OF JATYADI TAILA AND KARANJADI TAILA IN DUSHTAVRANA Here with I am enclosing completed prescribed Proforma for registration of subject for dissertation. Thanking you Place: Udupi Date: Yours sincerely (Dr.K.P Sreejith)

1. NAME OF THE CANDIDATE

DR.K.P. SREEJITH 1ST YR. MS DEPT.OF SHALYATANTRA

SDMCA, KUTHPADY.UDUPI.

PERMANENT ADDRESS

DR.K.P. SREEJITH S/O LATE K.R P NAMBOOTHIRY. KONDAMARUKU MANA METHIRY P.O RAMAPURAM.KOTTAYAM KERALA

2. NAME OF INSTITUTION

S.D.M. COLLEGE OF AYURVEDA KUTHPADY, UDUPI -574118

3. COURSE OF STUDY & SUBJECT 4. DATE OF ADMISSION 5. TITLE OF THE TOPIC

: M.S. (AYU) IN SHALYATANTRA : 2/6/2008 :

COMPARATIVE STUDY OF JATYADI TAILA AND KARANJADI TAILA IN DUSHTAVRANA

6. BRIEF RESUME OF THE INTENDED WORK: 6.1 NEED FOR STUDY:

In every aspect management of chronic/ non-healing ulcer is a challenge to surgeons. Therefore a primary attention is needed for healing of wound with in a short span of time with out any complications. As such there is a lack of comparative studies of thaila upakramas. Hence to fulfill this lacuna present study is taken up. In the management of vrana, Acharya Susruta has mentioned 60 different upakramas,taila is one among them for sodhana and ropana.1,2,3 It should be used for sodhana of vrana when it has the following characteristics; 1.Unnata mamsa, 2.Asnigdha 3.Alpasrava yukta, Indication of taila upakrama for ropana, when there is predominancy of vathakapha dosha. Karanjadi taila, which is the Taila form of Karanjadi Ghritha 4, is indicated for dushtavrana in vidradhi adhyaya and also in medoarbuda chikitsa of Susruta Samhita.5 Jatyadi taila is mentioned in Bhavaprakasa for dushtavrana. 6 Previously works have studied them individually. The results of the study was encouraging in terms of size reduction of the wound and other features. The present study is very much merited to compare the effects of the two tailas in management of Dushta vrana. The study will be carried out to evaluate the clinical effects of Jatyadi taila and Karanjadi taila separately on dushtavrana. The study is planned to do in those ulcers which are mentioned as indications of Taila upakramas.

6.2 REVIEW OF LITERATURE:

This section will contain: Description of dushta vrana in Ayurveda.7 Description and drugs used in Jatyadi taila and Karanjadi taila.4,6 Description of taila upakrama in Ayurveda.1,2,3 Description of treatment of ulcer in Modern surgery.8 Description of ulcers and chronic ulcers in Modern surgery.9

6.3 PREVIOUS WORK DONE7: 1. Panduranga Rao, Management of dushtavrana with Karanjadi taila. Dr.BKRR Govt. Ayu.College AP University, Vijayavada. 1991.10 2. Bhatt Rajesh, Effect of Nimbadi taila in the management of Dushtavrana, Faculty of Ayurvedic Institute of Medical Sciences, Banaras Hindu University, Varanasi, 2000.10 3. Prasad. K, management of Dusta Vrana with Sapthanga Guggulu (internally) and Karanjadi ghrita(externally) Dr.BKRR Govt. Ayu. College AP University, Vijayavada 2001.10 4. Shetty Naarayan, Effect of Ksharataila in Dushtavrana, Govt.Ayurveda College, Bangalore, RGUHS, Bangalore, 2001.10 5. Chikaram M.K, Efficacy of Nirgundi taila for Vrana ropana-Sodhana in the treatment of Dushtavrana, Tilak Ayurveda Mahavidyalaya, Pune University, Pune. 2005.10 6. Keerthana C.J, The study of Triphala kwatha parisheka and Jatyadi taila application in the Manegment of Dushtavrana, SDMCA, RGUHS, Bangalore, 2006.11 7. Dr.Madhu.T, Efficacy of Jatyadi taila in the management of Dushtavrana SDMCA Udupi. RGUHS, Bangalore, 2004.12 6.4 OBJECTIVES OF STUDY: To study in detail about dushtavrana and chronic ulcers. To compare the efficacy of Jatyadi taila and Karanjadi taila in the management of dushtavrana.

7. MATERIALS AND METHODS:-

7.1) STUDY DESIGN:

This is a single blind randomized study with Pretest-Post test design. SOURCE OF DATA:The comparative study will be planned to evaluate the efficacy of Jatyadi taila and Karanjadi taila on Dushtavrana. Patients attending the O.P.D $ I.P.D of SDM Ayurveda college, Kuthpady,Udupi will be the source of data. 7.2METHOD OF COLLECTION OF DATA:Minimum of 20 patients suffering from dushtavrana in an age group of 18-60 yrs will be selected randomly and will be subjected to clinical trial. The selected patients are categorized in 2 groups of 10 each. Group A in this group Jatyadi taila is used for application on dushta vrana Group B in this group Karanjadi taila is used for application on dushta vrana INTERVENTION: First wound will be cleaned by using Triphala kwatha, then gauze dipped in Jatyadi taila is to be applied for Group A. The same procedure will be carried out for group B with Karanjadi taila. DURATION OF TREATMENT: The duration of treatment will be of one month or the time taken by the wound to heal properly.

OBSERVATION PERIOD: The changes in the Ulcer will be observed daily, till the Dushtavran (Vitiated ulcer) becomes Sudhavrana and thereafter, it will be observed once in a week till it attain Rudha vrana avastha. FOLLOW UP PERIOD- one month

INCLUSION CRITERIA: Patients aged between 18-60 yrs. Patients of either sex are taken. Patients of dushtavrana with following characteristic like; 1. Chronic ulcers 2. Wound with less discharge 3. Wound with raised surface EXCLUSION CRITERIA: Tubercular ulcers Malignant ulcers. HIV infection and AIDS.

ASSESSMENT CRITERIA: The patients will be assessed on the basis of subjective & objective parameters before and after treatment. SUBJECTIVE PARAMETERS Pain Burning sensation Itching Tenderness. Smell. Granulation tissue and floor. Color of the surrounding area of ulcer.

OBJECTIVE PARAMETERS Size of the wound Discharge Warmth(Local Temperature) Indurations measured in millimeters in the base of the ulcer.

INVESTIGATIONS Routine Blood and Urine analysis. 7

Blood sugar. Other necessary investigations if needed.

7.3 Does this study require any investigations or intervention to be conducted on patients or other humans or animals? If so please describe briefly. The study will be a human clinical study: no animal experimentation will be conducted. 7.4. Has the ethical clearance is obtained from your institution? YES, ethical clearance is obtained through the ethical committee formulated in this institution. 8.LIST OF REFERENCES:1. Susrutha/ Acharya vaidya Yadavji Trikamji.Susruta Samhita.chikitsa stana Varanasi, Chaukamba surbharti prakasha, 2007, p 397, pp824. 2. Susrutha/ Acharya vaidya Yadavji Trikamji.Susruta Samhita.chikitsa stana Varanasi, Chaukamba surbharti prakasha, 2007, p 402, pp824. 3. Susrutha/ Acharya vaidya Yadavji Trikamji.Susruta Samhita.chikitsa stana Varanasi, Chaukamba surbharti prakasha, 2007, p 403, pp824. 4. Susrutha/ Acharya vaidya Yadavji Trikamji.Susruta Samhita.chikitsa stana Varanasi, Chaukamba surbharti prakasha, 2007, p 465, pp824. 5. Susrutha/ Acharya vaidya Yadavji Trikamji.Susruta Samhita.chikitsa stana Varanasi, Chaukamba surbharti prakasha, 2007, p 474, pp824. 6. Bhavamishra/ Prof. K.R. Srikantha Murthy. Bhavaprakash, Varanasi,Choukhamba Krishnadas Academy, p 565, pp884. 7. Susrutha/ Acharya vaidya Yadavji Trikamji.Susruta Samhita.sutra stana Varanasi, Chaukamba surbharti prakasha, 2007, p 108, pp824. 8. Roshan Lall Gupta/ text book of surgery, chapter 6 ulcers sinuses & fistulae, IInd addition 2003, New Delhi, Jaypee brothers medical publishers, p 63,
pp

1274.

9. S.Das, A Concise text book of surgery, Chapter 11 Ulcer Sinus & Fistula, 3 rd Edition-2001, Calcutta, Dr.S.Das old Mysore court., p 126, pp1324. 10. Baghel M.S, Researches in Ayurveda, 2nd Edition, Jamnagar, Mridu Ayurvedic Publication & Sales, 2005, pp-381. 11. Thesis List, SDMCA, Kuthpady, Udupi, unpublished.

12. Baghel M.S, Researches in Ayurveda, 2nd Edition, Jamnagar, Mridu Ayurvedic Publication & Sales, 2005, P 202, P84, 178, 264, pp-381.

9. SIGNATURE OF THE CANDIDATE:

10. REMARKS OF THE GUIDE:

11. NAME & DESIGNATION OF GUIDE R.RAMACHANDRA

Dr.K. BSc.MD(AYU) PROFESSER AND HOD DEPT OF STUDIES IN SHALYAT

ANTRA SDM COLLEGE OF AYURVEDA, UDUPI 11.1. SIGNATURE 11.2. CO GUIDE MS(AYU) Dr.JAYAKRISHNA NAYAK LECTURER DEPT OF STUDIES IN SHALYATANTRA SDM COLLEGE OF AYURVEDA, UDUPI 11.3. SIGNATURE: 11.4. HEAD OF THE DEPT: DR. .R.RAMACHANDRA B.SC. M.D. (AYU) HOD &PROFESSOR DEPT. OF SHALYATANTRA S.D.M.C.A. UDUPI

11.5. SIGNATURE: 12. REMARKS OF THE CHAIRMAN& PRINCIPAL: 12.1 SIGNATURE:

10