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BIOACTIVITY OF ANDROGRAPHIS PANICULATA COLLECTION OF RESEARCH Year / Researcher 2000 / Zhang XF, Tan BK Title Anti-diabetic property of ethanolic

extract of Andrographis paniculata in streptozotocin-diabetic rats. Conclusion The ethanolic extract of A paniculata possesses antidiabetic property. Its antidiabeticeffect may be attributed at least in part to increased glucose metabolism. Its hypotriglyceridemic effect is also beneficial in the diabetic state Hasil penelitian ini menunjukkan bahaa bakteri uji yang paling sensitif terhadap ekstrak daun sambiloto adalah Salmonella sp . Dan meningkatnya konsentrasi ekstrak daun sambiloto meningkatnan pula secara nyata (P<0,05) diameter daerah hambat yang terbentuk. These results suggest that andrographolide is an interesting pharmacophore with anticancer and immunomodulatory activities and hence has the potential for being developed as a cancer therapeutic agent In conclusion, the present investigation clearly showed that Andrographis paniculata crude extract had a very great potential as drug alternative in diabetic patients and related disorder. Hasil penelitian menunjukkan bahwa filtrat daun sambiloto dan tetrasiklin berpengaruh terhadap pertumbuhan Shigella dysenteriae sedangkan konsentrasi filtrat daun sambiloto yang paling efektif untuk menghambat pertumbuhan Shigella dysenteriae adalah konsentrasi 80%-100%, karena setelah dibandingkan dengan tabel standart NCCLS pada konsentrasi ini diameter zona hambatnya lebih besar dari tabel NCCLS yaitu 29 mm, Sehingga Shigella dysenteriae bersifat sensitif tehadap sambiloto dan antibiotik tetrasiklin Both these two plant extracts in combination

2000 / Masniari Poeloengan

Daerah hambat ekstrak sambiloto pada tiga isolate bakteri gram negatif

2003 / Rajagopal S, Kumar DS, Satyanarayana C, Rajagopalan R

RA, Deevi

Andrographolide, a potential cancer therapeutic agent isolated from Andrographis paniculata

2006 / Asmah Rahmat et all

Effects of Andrographis Paniculata Crude extract in normal and alloxan induced hyperglycaemic rats

2006 / Nur ichsan

Pengaruh filtrate daun sambiloto terhadap diameter zona hambat shigella dysentriae secara in vitro

2009 / Kirti Mishra1, Aditya P Dash2, Bijay K

Anti-malarial

activities

of Andrographis

Swain3 and Nrisingha Dey

paniculata and Hedyotis corymbosa extracts and their combination with curcumin Bacteriostatic and bactericidal activities of Andrographis paniculata extracts on skin disease causing pathogenic bacteria

2010 / Abubakar sule dll

2010 / Abhisek niranjan, SK tewari

Biological activities of Kalmegh and its active principles a review

2010 / Edijanti Goenarwo1, Chodidjah2* dan Rosy Kusuma3

Perbedaan Kadar SGOT antara Pemberian Air Rebusan Daun Sendok (Plantago major) dan Daun Sambiloto (Andrographis paniculata Ness) Studi Eksperimen pada Tikus Putih Jantan Galur Wistar yang Diinduksi Parasetamol

2010 / A. Sule1, Q.U. Ahmed*2, O.A. Samah1, and M.N. Omar

Screening for Antibacterial Activity of Andrographis paniculata Used in Malaysian Folkloric Medicine: A Possible Alternative for the Treatment of Skin Infections

2011 / Kirti Mishra,1 Aditya P. Dash,2 and Nrisingha Dey3

Andrographolide: A Novel Antimalarial Diterpene Lactone Compound from Andrographis paniculataand

with curcumin could be an effective, alternative source of herbal anti-malarial drugs. These results candidly suggest the presence of promising antibacterial substances in the polar as well as non-polar extracts which could be the source of potential phytomedicine for the treatment of skin infections caused by the pathogenic bacterial strains. Our findings explicitly support its traditional claims and form a strong basis for further sincere efforts to explore A. paniculatas antibacterial potential to treat skin frailties efficaciously. Kalmegh extract protects lipid, haemoglobin and red blood cells from lipid peroxidation. It prevents oxidative damage and inhibits binding to toxic metabolites to DNA. Safety evaluation studies indicate that kalmegh is well tolerated at very high dose without any toxic effects. The boiled aquous of sendok and sambiloto leave might have an effect to decrease the SGOT level. The boiled aquous of sendok and sambiloto leave might decrease the SGOT level of the paracetamol induced rats during the 16 day, but the decreasein of SGOT level on boiled aquous of sambiloto leave treatment was higher than in sendok group The present study explicitly exhibited the antibacterial effect of various extracts of Andrographis paniculata against skin infections causing bacterial strains. The inhibitory effect of the extracts justified the medicinal use of Andrographis paniculata in the treatment of skin infirmities by traditional practitioners and further study is mandatory to find out the active principles of medicinal value. The compound was found to have potent antiplasmodial activity when tested in

Its Interaction with Curcumin and Artesunate

2011 / Ramya Premanath and N. Lakshmi Devi

Antibacterial, Antifungal And Antioxidant Activities Of Andrographis Paniculata Nees. Leaves

2011 / K.Sathiyaraj1, A.Sivaraj1, T.Thirumalai2, N.Baskaran3, K.Vinothrasu3, P.Inbasekar4, B.Senthil kumar*1 2011 / Wasman, Mahmood

Antifertility Activity of Aqueous Leaf Extract of Andrographis paniculata in Male Albino Rats

isolation and in combination with curcumin and artesunate against the erythrocytic stages of Plasmodium falciparum in vitro and Plasmodium berghei ANKA in vivo ethanolic extract of A. paniculata leaves gave the highest phenolic and flavonoid contents and showed potent antibacterial and antifungal activity against UTI causing bacteria and dermatophytes respectively. This explains the use of A. paniculata in folk medicine for treatment of infectious diseases. It was evident from the present study that, ethanolic extract of A. paniculata leaves showed strong lipid peroxidation inhibitory activity, DPPH scavenging activity and superoxide scavenging activity. On the basis of the results obtained, it can be concluded that ethanol is the best solvent for extracting antimicrobial and antioxidant bioactive compounds (phenols and flavonoids). The results suggest that the aqueous extract of the leaves of Andrographis paniculata has spermicidal activity pretreatment with ethonolic extract of A. paniculata ethanolic provided significant protection against gastric ulcer by regulating of pH, mucous production and antioxidant property The biochemical estimation results revealed the presence of carbohydrates, proteins, phenolics, flavonoids, saponins and alkaloids. Thus, the antimicrobial and antioxidant activity of A. paniculata is responsible for the phenolics, flavonoids, saponins and alkaloids. And carbohydrates and proteins give the nutritive value of A. paniculata. (Plate 10). On the basis of presented results, we can consider the in vitro raised plants of Andrographis

Antioxidant and gastroprotective activities of Andrographis paniculata (Hempedu Bumi) in Sprague Dawley rats.

2011 /Ankita Kataky, PJ Handique

BIOASSAY OF Andrographis paniculata

MICROPROPAGATED

2011 / Meenu Sharma* And Suman Joshia

Comparison Of Anti-Oxidant Activity Of Andrographis Paniculata And Tinospora Cordifolia Leaves

2011/Yudit Oktanella

Efek Kombinasi Echinacea Purpurea Dan Andrographis Paniculata Sebagai Hepatoprotektor Pada Tikus Putih Yang Terpapar Stres Panas

2011 /R. Radha, M. Sermakkani* And V. Thangapandian

Evaluation Of Phytochemical And Antimicrobial Activity Of Andrographis Paniculata Nees (Acanthaceae) Aerial Parts

2011 / Anil U. Tatiya, Sanjay J. Surana, Manisha P. Sutar, and Nehal H. Gamit

Hepatoprotective effect of poly herbal formulation against various hepatotoxic agents in rats

2011 / Vetriselvan.S*., Victor Rajamanickam**.,Muthappan.M***.,Gnanasekaran.D Dinesh Kumar Chellappann

Hepatoprotective Effects Of Aqueous Extract Of Andrographis Paniculata Against Ccl4 Induced Hepatotoxicity In Albino Wistar Rats

2011 / A. Sivaraj, P. Vinothkumar, K. Sathiyaraj, S. Sundaresan, K. Devi

Hepatoprotective potential of Andrographis paniculata aqueous leaf extract on ethanol induced

paniculata are equally potent as that of the wild plants. The result obtained from our study may vary from the earlier reports due to environmental differences within species, time of taking samples and determination methods. As methanolic extract of leaves of A. paniculata had good percentage of TPC and flavonoid content, the above findings recommend the further investigation of A. paniculata leaves to evaluate their chemical potential. kombinasi ekstrak Echinacea purpurea dan Andrographis paniculata mampu mempertahankan kadar enzim SGOT dan SGPT pada tikus putih (Rattus norvegicus) yang dibuat menderita stres panas dalam batas normal, seperti pada kelompok kontrol negatif The antibacterial activity is more significant against Gram positive bacterium Enterococcus faecalis whereas the antifungal activity is more significant against Aspergillus flavus. These results may justify the popular use of this species as it has antimicrobial activity. Results suggests that the hepatoprotective effects of PHF might be useful for liver protection due to combined action of all plant extracts along with their phytoconstituents. It can be concluded that the aqeous extract of A.Paniculata have significant hepatoprotective on CCL4 induced hepatic damage(14,15) in rats, as evidence by the biochemical parameters.further work is in progress to isolate and characterise the active principles in these extracts .The result of this study demonstrate that A.Paniculata has a potent hepatoprotective action on CCL4 induced hepatic damage in rats. The aqueous leaf extract of A.paniculata could protect the liver against ethanol induced liver

and B. Senthilkumar

liver toxicity in albino rats

2011/Sarala V1, Balagurunathan2*

M.

Radhakrishnan1

and

R.

Inhibitory activity of Terpenoid from the Medicinal plant Andrographis paniculata against Biofouling bacteria

2011 / Chinnappan Alagesaboopathi

Phytochemical analysis and antimicrobial evaluation of Andrographis lineata Nees leaves and stem extracts

2011 / Kuppusamy CHENNIAPPAN

Synergistic Activity of Andrographis paniculata Nees with Bacilus thuringiensis var israelensis Against Malarial Vector, Anopheles stephensi Liston (Diptera: Culicidae)

2012 / Agung Endro Nugroho

Antidiabetic and antihiperlipidemic effect of Andrographis paniculata (Burm. f.) Nees and andrographolide in high-fructose-fat-fed rats

toxicity by possibly reducing the rate of lipid peroxidation and increasing the antioxidant defense mechanism in rats The present study concluded that the widely available medicinal plant Andrographis paniculata can, not only provide active compound for clinical application but also for controlling fouling organisms, which pose major threat to shipping industry. The results of the current study revealed that antibacterial efficacies of acetone, ethanol, methanol, petroleum ether and chloroform extracts varied in effectiveness which may be attributed to the presence of saponins and tannin. The presence of phenolic compounds in the plant indicates the antimicrobial properties. In the present research, the author also observed the antibacterial assay, which agrees with the findings of Ofokansi et al. (2005). The phytochemicals are Known to have antimicrobial properties (Gupta et al., 2010). Hence, these plants can be used to discover bioactive natural products that may lead to the development of new pharmaceuticals research activities Combined formulations were evaluated for synergistic activity and a 1:4 ratio of Bti and Ee was observed to be more effective than 1:2 and 1:1 ratios. However the larvicicdal activity is minimal when the mixed formulations contained an equal amount of both constituents (i. e a 1: 1 ratio). A ratio of 1: 4 of Bti and Ee of A. paniculata was 51.6 fold more toxic at the LC90 for larvicidal activity, than Bti alone and this high level of activity resulted from synergism between the Bti and Ee of A. paniculata Nees. Andrographis paniculata (Burm. f.) Nees or its active compound andrographolide showed hypoglycemic and hypolipidemic effects in

2012 / Abubakar sule dkk

Antifungal activity of Andrographis paniculata extracts and active principles against skin pathogenic fungal strains in vitro

2012 / Chatuphonprasert W dkk

Differential Induction of Murine Hepatic CYP1A1 Expression by Diterpenoids Isolated from Andrographis Paniculata Depends on Different Aryl Hydrocarbon Receptor Binding Site

2012 /I gede Parama Gandi Semita

Efek Antimikroba Dari Ekstrak Etanol Daun Dan Pucuk Batang Tumbuhan Sambiloto (Andrographis Paniculata) Terhadap Escherichia Coli Strain Extended Spectrum Beta Lactamase (Esbl)

2006 / Nalamolu Koteswara Rao

Anti hyperglycemic and renal Protective Activities of Andrographis paniculata Roots Chloroform Extract

2011 / S Vetriselvan, et al

Hepatoprotective activity of Andrographis paniculata in Etahnol Induced Hepatotoxicity in Albino Wistar Rats

high-fat-fructose-fed rat. This is first report on the isolation of antifungal substances through bioassay-guided assay from A. paniculata. Our finding justifies the use of A. paniculata in folk medicines for the treatment of fungal skin infections Molecular docking analysis is a useful tool to predict effect of compounds on CYP1A1 induction. Moreover, use of A. paniculata as a health supplement should be concerned in term of herb-drugs interactions or risk of carcinogenesis, according to its ability to modify CYP1A1 expression. Hasil yang diperoleh dari pengujian efek bakteriostatik / bakterisida ekstrak etanol daun dan ujung batang sambiloto terhadap strain Escherichia coli ESBL adalah bahwa 10 Escherichia coli galur ESBL (100%) telah berhasil dihambat dan dibunuh oleh ekstrak etanol daun dan ujung batang sambiloto . Dapat disimpulkan bahwa ekstrak etanol daun dan ujung batang sambiloto memiliki antimikroba sampai efek bakterisidal terhadap strain Escherichia coli ESBL. The present study clearly indicated a significant antidiabetic activity with the chloroform extract of A. paniculata roots and supports the traditional usage of the plant by Ayurvedic phy-sicians for the control of diabetes. Also the extract is useful in preventing the incidence of long-term complication, diabetic nephropathy. In this study, The extract of Androgrphis Paniculata produced adequate hepatoprotective activity on albino wistar rats. The dose levels selected for studies were 50

2006 / Rudi Mahruzar

Uji klinis Herba Sambiloto tunggal disbanding kombinasi dengan klorokuin pada pengobatan malaria falciparum tanpa komplikasi

mg/kg, 100mg/kg and 200mg/kg. Histopathological examination of the liver section of the rats treated with toxicant showed intense centrilobular necrosis and vacuolization. The rats treated with extracts along with toxicant showed sign of protection against these toxicants to considerable extent as evident from absence of necrosis and vacuoles. Thus it was concluded that the extract exhibited significant dose dependent hepatoprotective activity. Esktrak herba sambiloto (EHS) 250 mg dalam sediaan kapsul efektif sebagai antimalaria pada malaria falciparum tanpa komplikasi Efikasi EHS 250 mg 3 kali sehari selama 5 hari pada pasien MF tanpa komplikasi sebesar 91,3% Kombinasi EHS 250mg dengan klorokuin tidak meningkatkan efikasi antimalarianya (90,9%) pada pasien MF tanpa komplikasi Pemberian EHS 250mg tidak menimbulkan efek samping yang berarti