EMBRYOLOGY

BY 314-4A; Spring 2011 Dr. Trygve Tollefsbol NOTE: THIS IS THE SPRING 2011 BY 314 SYLLABUS. THE 2012 SYLLABUS FOR THIS COURSE WILL BE POSTED AT A LATER DATE. Office: Room 175A Campbell Hall Office Hours: M 11-12 or by appointment (e-mail: trygve@uab.edu; phone: 934-4573) Textbook: Developmental Biology--9th Edition (2010)/S.F. Gilbert (Sinauer Associates, Inc.) COURSE DESCRIPTION: Examination of the molecular, cellular and organizational processes involved in early development from oogenesis and spermatogenesis through fertilization and the completion of embryogenesis. COURSE OBJECTIVE: To facilitate understanding of the basic molecular and cellular processes that contribute to the structure and function of developing organisms and the interdependent nature of these processes during embryogenesis. TENTATIVE CLASS SCHEDULE Date Jan. 4 Jan. 6 Jan. 11 Jan. 13 Jan. 18 Jan. 20 Jan. 25 Jan. 27 Topic Class Orientation/Introduction to Embryology Spermatogenesis Oogenesis Oogenesis Fertilization Egg Activation Genes and Development I Genes and Development I/II Pages pp. 1-17; 323-331 pp. 592-610 pp. 585-591; 610-615 pp. 585-591; 610-615 pp. 121-138 pp. 139-158 pp. 31-33 and Class Notes pp. 31-33 and Class Notes

Feb. 1 Feb. 3 Feb. 8 Feb. 10 Feb. 15 Feb. 17 205; 241288; 300-304 Feb. 22 205; 241288; 300-304 Feb. 24

Genes and Development II Exam I Morphogenesis

pp. 31-33 and Class Notes

pp. 17-18; 69-79

No class meeting (Dr. Tollefsbol at NIH Study Section) Morphogenesis Cleavage and Blastulation pp. 17-18; 69-79 pp. 159-163; 165-166; 178-180; 187-188; 192-193; 204244; 273-276; 287-

Cleavage and Blastulation

pp. 159-163; 165-166; 178-180; 187-188; 192-193; 204244; 273-276; 287-

Gastrulation

208; 244295; 304-311 March 1 Gastrulation 208; 244295; 304-311 March 3 March 8 March 10 March 15 March 17 Transcriptional Control and Development DNA Methylation and Developmental Gene Activity

pp. 162-164; 172-178; 185-186; 191-192; 199-202; 206252; 277-284; 288pp. 162-164; 172-178; 185-186; 191-192; 199-202; 206252; 277-284; 288-

pp. 35-45 pp. 48-53; 66

No class meeting (Dr. Tollefsbol attending scientific conference) Spring Break Spring Break

March 22 March 24 March 29 March 31 Apr. 5

DNA Methylation and Developmental Gene Activity Exam II X-chromosome Inactivation/Genomic Imprinting X-chromosome Inactivation/Genomic Imprinting RNA Processing and Translation in Development

pp. 48-53; 66

pp. 50-52; 154-155 pp. 50-52; 154-155 pp. 37-38; 53-61; 218-225; 529533; 672-673 pp. 37-38; 53-61; 218-225; 529533; 672-673 pp. 541-560 pp. 541-560 pp. 511-540 pp. 511-540

Apr. 7

RNA Processing and Translation in Development

Apr. 12 Apr. 14 Apr. 19 Apr. 21 Apr. 28

Hormones as Mediators of Development Hormones as Mediators of Development Sex Determination Sex Determination Final Exam, 4:15 pm - 6:45 pm

Evaluation: Exam I Exam II Final Exam (not comprehensive) Total

100 pts. 100 pts. 100 pts. 300 pts.

Final Grade: 90-100% (270-300 pts.) 80-89% (240-269 pts.) 70-79% (210-239 pts.) 60-69% (180-209 pts.) 0-59% (< 180 pts.) A B C D F

Grading: Examinations will be primarily on lecture material. Portions of the lecture material (subject to testing) may not be in the text. The text is provided to complement the class notes. Exams must be taken on the date indicated during the regular class schedule. Makeup exams will only be given in exceptional circumstances (i.e., medical or family emergency documented in writing). Withdrawal Policy: You may withdraw and receive a grade of W up to and including March 24. After that date you may not withdraw. See the most recent Undergraduate Catalog for the full text of this policy. ONLINE INFORMATION FOR THE COURSE APPEARS IN TWO PLACES: A. Class Notes: I intend to provide the notes of each lecture on the internet. The location for the class notes is "http://main.uab.edu/show.asp?durki=19487". Within each site will be the notes used for class lectures. B. All of the transparencies from the class lectures will also be placed on the internet. To access these materials, follow these links: 1. Start at the UAB main page (http://main.uab.edu) 2. Click Libraries 3. Click Mervyn H. Sterne Library 4. Click Local Catalog 5. Click Course Reserves 6. In the Instructor box, scroll down to select Tollefsbol, Dr. Trygve 7. Click Search 8. Select the desired lecture to download. For example, under Title, click Introduction to Embryology to download the first lecture of the course. 9. Select Click here to access an electronic copy of this item. This will access the handout summary sheet(s) and scans of the transparencies used for the lectures. 10. Bookmark as desired.

If you have any problems with accessing the required online information for the course, please either contact the information desk at the Sterne Library or Dr. Tollefsbol. This should be done relatively early in the course to make sure you know how to access all of the materials. Students are also responsible for the required textbook readings as delineated above. Students are encouraged not to solely rely on information provided on the internet since test questions are also derived from material discussed in class that may not be explicit in the notes on the internet.