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PRESENTATION OUTLINE
1- Herbal Medicinal Products (HMP)
2- Drying/encapsulation of herbal preparations
- harvesting period, - post-harvest processing, such as drying and storage conditions (mainly temperature and relative humidity).
inflorescence, etc.).
- Addition of carriers is almost mandatory.
2.1 Advantages
- High concentration of bioactive compounds - Reduction in volatile losses -Taste and odor masking - Lower risk of microbial growth - Reduction in transport and storage costs - Superior product stability and Shelf life - High added value.
Bauhinia forficata
Bidens pilosa
Cissus verticillata
Camellia sinensis
Psidium guajava
Hymenaea courbaril
Sygizium aromaticum
Arrabidaea chica
Ananas comosus
Eugenia pyriformis
Carriers Addition
Drying
Fluid bed drying Parameters (Tgi, Tgo, Wg, Ws/Wmax, Cs, bed of inerts, atomization)
Powder properties Xp, thermal degradation, solubility, pH, bulk and tapped density, size and particles morphology, thermal behavior, color, chemical composition, stability testing
2.4 Carriers
-cyclodextrin
Aerosil:Cellulose MC 102 (25:75)
http://www.andaluciainvestiga.com/sgcArchivos/FQM/grandes/ci clodextrina.jpg www.worldsbestoil.ca/Amsoil-Image-
Cellulose
Aerosil
Colloidal silicon Aerosil
dioxide
http://www.nauticurso.com.br/loja/product_info.php?products_i d=523
Drying process
Spray drying
Freeze drying
Drying composition F1 F2 F3
F4
* Dry basis
Aerosil 200
25
Maltodextrin DE 10
75
Dryers used
Spray dryer
Tgi = 150 C, Ws/Wmax =15 % Q = 60 m3/h (SD) and Q = 72 m3/h (SBD) H0 = 7.0 cm (SBD)
SD
* chemical composition (HPLC), Xp, thermal degradation, solubility, size, particles morphology, X-ray diffraction, bulk and tapped density, thermal behavior, color, stability
SB
Rutin
Hyperoside
polyacetylene
H H3 C OH H O R aucar www.bktechnology.com
Markers degradation
Spouted bed drying
F1 F2 F3 F4
-cyclodextrin
b
SB
SD
1000X
- X-ray diffraction
Encapsulated Extract
Herbal Extract
Lippia sidoides
Essential Oil
Spray drying
Title: Microparticle containing volatile compounds, production process and pharmaceutical compositions (Brazilian Patent PI0704902-1A2)
Fang, Z. and Bhandari, B. Trends in Food Science & Technology 21 (2010) 510-523
* Ultrasound processing
Spray drying/cooling
(a)
(b)
(c)
(d)
Fluid and spouted bed dryers a) bed with atomizer above; b) Wurster-type bed; c) rotary fluid bed d) bidimensional spouted bed. (Source: http://www.glatt.com)
4. Closing remarks
Needs:
Technologies for the standardization, preservation and enhancement of stability and bioavailability of natural bioactive compounds.
Strategies:
Delivery systems for natural products through encapsulation technologies, improving their interaction with biological barriers and perhaps providing target delivery.
Quality assurance:
Stability testing of product should also be pursued in order to guarantee their quality, efficacy and safety during shelf life.
Research Group
Prof. Dr. Wanderley Pereira Oliveira Prof. Dra. Claudia Regina Fernandes Souza M.Sc. Marcelo Luiz Lombardi Martinez MSc. Maurette R. V. Fernandes
M.Sc. Tales Alexandre da Costa e Silva M.Sc. Diego F. Corts Rojas M.Sc. Lucimara Benelli M.Sc. Maira Neto Zampir Danielle Nishida Ramos Camila Manoel Crnkovic
Financial support:
Laboratory of R&D on Pharmaceutical Processes Researches on Drying and Agglomeration of Pharmaceuticals and Bioproducts:
1. Development and standardization of dried phytochemical preparations from medicinal and aromatic plants 2. Micro- and Nano-encapsulation of bioproducts through drying
- Lipids
- waxes (carnauba and beeswax) - natural fats and oils - mono and di-glycerides - phospholipids - glycolipids
- Surfactants (GRAS status)
- Natural polymers - food proteins: - albumin; gelatin; vegetable protein; casein; b-lactoglobulin
- carbohydrates, hydrocolloids) - Arabic gum; hydrolyzed starch; maltodextrins; chitin; chitosan; alginates; guar gum; xhantam gum; cellulose and cellulose derivates,..