Faculty of Pharmacy, DDU, Syllabus of B. Pharm Programme THIRD YEAR B. PHARM.

Subject code PH301 PH302 PH303 PH304 PH305 PH306 Ph307 Subjects Pharmaceutics-IV (Dispensing, Hospital, & Community) Pharmaceutical Microbiology & Biotechnology Pharmaceutical Chemistry-IV (Analytical) Pharmaceutical Chemistry-V (Medicinal) Pharmacognosy-II Pharmacology-II (Pharmacology & Pathophysiology) Pharmaceutical Jurisprudence & Ethics Total Marks Theory Practical 100 100 100 100 100 100 100 100 700 100 100 100 100 100 600 Hours/ Week Theory Practical 3 3 3 4 3 3 3 2 21 3 3 3 3 3 18

PH301 Pharmaceutics-IV (Dispensing, Hospital, & Community) Theory 3hrs/week 1. Definition and scope. 2. The prescription: Handling of prescription, source of errors in prescription, care required in dispensing procedures including labeling at dispensed products. 3. Dispensing techniques: Compounding and dispensing procedures, packaging, storage and stability of medicines, labeling of dispensed product. 4. Pharmaceutical calculations: Posology: Calculation of doses for infants, adults and elderly patients, enlarging and reducing recipes, percentage solutions, allegation, alcohol dilution, proof spirit, isotonic solutions, displacement value etc. 5. Principles involved and procedures adopted in dispensing of Mixtures, solutions, emulsions, external preparations, suppositories & pessaries, powders and granules, oral unit dosage forms, inhalations. 6. Incompatibilities: Physical, chemical and therapeutic incompatibilities observed in prescriptions of above products: - Identification and correction of incompatibilities. - Inorganic incompatibilities including incompatibility of metals and their salts, non metals, acids, alkalis. - Organic incompatibilities: purine bases, alkaloids, ammonium compounds, carbohydrates, glycosides, anaesthetics, surface active agents. 7. Community Pharmacy: - Organisation and structure of retail and wholesale drug-store, types of drug store and design, legal requirements for establishment, maintenance of drug store, dispensing of proprietary products, maintenance of records of retail and wholesale. - Patient counseling. - Role and contribution of pharmacist in community health care and education. 8. Hospital Pharmacy: a) Organization and structure: Organization of hospital and hospital pharmacy, responsibility of hospital pharmacist, pharmacy and therapeutic committee, budget preparations and implementation. b) Hospital formulary: contents, preparation and revision of hospital formulary. c) Drug store management and inventory control. - Organization of drug store, types of material stocked, storage conditions. - Purchase and inventory control principles purchase procedures purchase orders procurement and stocking. d) Drug distribution system in hospitals. - Outpatient dispensing methods adopted. - Inpatient dispensing methods adopted - Ambulatory patient dispensing methods adopted. - Dispensing of controlled drugs. e) Central sterile supply unit and their management. Types of materials for sterilization, packing of materials prefer to sterilization, sterilization equipments, and supply of sterile materials. f) Manufacture of sterile and non sterile products. Policy making of manufacturable items, demand and costing, personnel requirements, manufacturing practice, master formula card, production control, manufacturing records. g) Drug information services: Sources of information on drugs, disease treatment schedules, procurement of information, computerized services, retrieval of information, medication error. h) Records and reports: Prescription filling, drug profile, patient medication profile, cases on drug interaction and adverse reactions, idiosyncratic cases etc.

PH301 Pharmaceutics-IV (Dispensing, Hospital, & Community) Practical 3hrs/week 1. Dispensing of prescription falling under the categories: Mixtures, solutions, emulsions, external preparations, powders, suppositories, oral unit dosage forms, inhalations. 2. Dispensing procedures involving pharmaceuticals calculations, pricing of prescriptions and dosage calculations for pediatric and geriatric patients. 3. Dispensing of prescriptions involving adjustment of tonicity. 4. Identification of various types of incompatibilities in prescription, correction and dispensing. 5. Categorization and storage of pharmaceutical products based on legal requirements of labeling and storage. 6. Experiments based on sterilization of various types of materials used in hospitals. 7. Practicals designed on the use of computer d rug information centre, prescription filling, documentation of information on drug interaction. 8. Project report on visit of the near by community for counseling on the rational use of drugs and aspects of health care. 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. Books Recommended: Dispensing for Pharmaceutical students by Cooper and Gunn, S.J. carter, 12Th Edn. CBS Publishers. Pharmaceutical Dosage form and Drug delivery system, Howard C. Ansel, Lippincot Williams & Wilkins. Pharmaceutical Calculations, Mitchell J. Stoklosa and Howard C. Ansel, B.I. Waverly Pvt. Ltd., New Delhi. Pharmaceutical Practice Edited by A.J. Winfield& R.M.E. Richards. Hospital Pharmacy by William E Hassan, Henry Kimpton Publisher, London. Hospital Organization and Management by Kurt Dan Jonathan S. Ratich, 4 th Edn. CBS Publishers. Remington: The science and Practice of Pharmacy, Latest Edn., By Mack Publishing companhy. Drug and Cosmetic Act. And Rules by Vijay Malik. Pharmaceutical Practice By Diana M. Collett and Michale E. Aulton ELBS Publishers. "Dispensing Pharmacy (Pharmaceutics-II)" By Dr. G.K. Jani, B.S. Shah Publication.

PH302 Pharmaceutical Microbiology & Biotechnology Theory 3hrs/week 1. Introduction to the science of microbiology Ancient theories concerning the origin of life contribution of great scientists to this science. 2. Study of structure of bacterial cells, 3. Microscopy: Microscopes, their magnification, resolution, illumination and filters, working of different types of microscopes, micrometry, Electron Microscopy. 4. Identification of microbes, stains and types of staining techniques. Systematic studies of few selected organism. 5. Classification of microbes and their taxonomy: actionomycetes, bacterial, protozoa, fungi, ricketssia, spirochetes and viruses. 6. Nutrition, cultivation, isolation and identification of bacteria, actionomycetes, fungi, viruses, etc. 7. Microbial genetics and variation. 8. Molecular Biology and Biotechnology, Genetic recombination:, Conjugation, Protoplast fusion and gene cloning and their applications. Development of hybridoma for monoclonal antibodies, Microbial transformation, Antibiotic production, Fermentation. 9. Bacterial enzymes, Enzyme immobilization. 10. Control of microbes by physical and chemical methods of sterilization. 11. Disinfections, factors influencing disinfections, dynamics of disinfections, disinfectants and antiseptics and their evaluation. 12. Sterilization, different methods, validation of sterilization methods and equipments. 13. Sterility testing of all Pharmaceutical Products. 14. Microorganisms in human diseases. Microbial attack and host defense: virulence and Pathogen city, Immunity and primary and specific defensive mechanisms of body, infection and its transmission, interferon. 15. Microbial standardization of Antibiotics, Vitamins, Amino acids etc. 16. Environmental Microbiology: Aquatic Microbiology, Microbiology of domestic and waste water, Microbiology of food. PH 302 Pharmaceutical Microbiology & Biotechnology Practical 3hrs/week Experiments devised to prepare various types of culture media Sub culturing of common aerobic and anaerobic bacteria, fungus, and yeast, Various staining methods, various methods of isolation and identification of microbes, Sterilizing techniques and their validation, Evaluation of antiseptics and disinfectants, Testing the sterility of pharmaceutical products as per IP requirements, Microbial assay of antibiotics and Vitamins etc Demonstration of laboratory fermentor Others to illustrate the topics included in theory.

Books recommended: 1. Daan J. A. Crommedin Robert & Sindila, Pharmaceutical Biotechnology 2/e 2. Russell-Principles and Practice of Disinfections, Preservation and Sterilization 3/e, 1999 3. Brooks-Medical Microbiology 22e. 2001 4. W. Thompson, Bioassay techniques for Drug Developments 5. Hughes and Anderson's, Antibiotics Development and Resistance 6. Stephen Denyer Rosemund Baird:Guide to Microbiological Control In Pharmaceutical and Medical Devices. 7. Pharmaceutical Microbiology Sixth Edition, Edited by W. B. Hugo and A. D. Rusell, Backwell Science. 8. Principles of Microbiology, Ronald. M. Atlas, Second Edition. Wm. C. Brown Publishers 9. Bergey's Manual of Systematic Bacteriology, Williams and Wilkins-A Waverly Company PH303 Pharmaceutical Chemistry-IV (Analytical) Theory 4hrs/week The following techniques will be discussed with reference to the latest edition of the Indian Pharmacopoeia along with Pharmacopoeial applications, Pharmacopoeial validation of the instruments and numericals related to the theories. 1. Significance of quantitative analysis in quality control, Different techniques of analysis, Preliminaries and definitions, Significance figure, Rules for retaining significant digits, Types of errors, Mean data sets, Selection of sample, Precision & accuracy, Fundamentals of volumetric analysis, methods of expressing concentration, primary & secondary standards. USP parameters for method validation, rejection criteria, Q.test. 2. Theoretical considerations, principle, instrumentation, and applications in drug analysis and quality control of the following analytical techniques will be discussed: Non-aqueous titrations, Complexometric titrations, Miscellaneous methods of analysis such as : Diazotization titrations, kjeldahl method of nitrogen estimation, Karl Fisher titration, Oxygen flask combustion, geometry, Extraction procedure including separation of drugs from excipients, Chromatography: TLC, HPLC, GLC, HPTLC, Paper chromatography and column Chromatography, Potentiometry, Conductometry, Calorimetry, Polarography, Amperometry. 3. Ultraviolet and Visible Spectrophotometry: Electromagnetic Radiation (EMR),properties of EMR, Mechanism of Absorption of EMR by molecules, Factors affecting absorption position and absorption intensity, Laws of photochemistry, Deviations from Beer's Law, Instrumentation(components and their general working principles), single beam and double beam instruments, sample handling, selection of wavelength and band width, Applications (direct methods, indirect methods, analysis of mixtures) 4. Fluorimetry: Origin of fluorescence and phosphorescence, Factors affecting fluorescence intensity, Relationship of fluorescence and phosphorescence to molecular structure, Instrumentation (components and their general working principles), Applications. 5. Infrared Spectrophotometry: Origin of an I.R. spectrum, Instrumentation (components and their general working principles), Sample handling , A brief introduction to Fourier transform infrared spectroscopy (FTIR), Applications, Analytical shortcomings. 6. Nuclear Magnetic Resonance Spectroscopy: Magnetic properties of the nucleus, Origin of NMR spectrum, Chemical shift, Coupling, Factors affecting chemical shift and coupling, Instrumentation (CW and FTNMR), Brief introduction to 13CNMR. 7. Mass Spectrometry: Origin of mass spectra, Fragmentation rules, Recognition of molecular ion peak, Instrumentation, Applications. 8. Atomic Absorption and Atomic Emission Spectroscopy: Origin of atomic absorption and atomic emission spectra, Instrumentation, Qualitative and quantitative application of flame photometry. . Atomic Absorption and Atomic Emission Spectroscopy: Origin of atomic absorption and atomic emission spectra, Instrumentation, Qualitative and quantitative application of flame photometry. 9. Quality Assurance: Introduction to Basic principles and applications of QA and GLP: Importance and applications of ISO 9000 & 14000. Quality Review and documentation in QC laboratory and analytical method validation. PH 303 Pharmaceutical Chemistry-IV (Analytical) Practical 3hrs/week The students should be introduced to the main analytical tools through demonstrations. They should have a clear understanding of a typical analytical balance, the requirements of a good balance, weight, care and use of balance, methods of weighing and errors in weighing. The students should also be acquainted with the general apparatus required in various analytical procedures. 1. Standardization of analytical weights and calibration of volumetric apparatus. 2. Experiments involving separation of drugs from excipients. 3. Chromatographic analysis of some pharmaceutical products. 4. Exercises based on titration using potentiometric technique, determination of acid base dissociation constant and plotting of titration curves using pH meter. 5. Exercises involving polarimetry.

6. 7.

Exercises involving conductometric and polarographic technique. Quantitative estimation and general tests of at least ten formulations containing single drug or more than one drug, using instrumental techniques. 8. Complete Monograph of one or two raw materials as per I.P. 9. Estimation of Na+, K+, Ca++, ions using flame photometer. 10. Electro analytical techniques like pHmetry, potentiometry, conductometry. 11. Other analytical techniques like Polarimetry, Karl Fischer titration, identification of drugs by I.R.

Books recommended: 1. Principles of Instrumental Analysis - Skoog, Holler, Nieman, 5th Ed. Saunders College Publishing. 2. A Textbook of Pharmaceutical Analysis - Kenneth A. Connors, 3rd Ed., John Wiley & Sons. 3. Instrumental Methods of Chemical Analysis - Galin W. Ewing, 5th Ed., McGraw Hill International Editions. 4. Principles of Instrumental Analysis - Skoog, Leary, 4th Ed., Saunders college Publishing 5. Instrumental Methods of Analysis - Willard, Merritt, Dean, Settle, CBS Publishers 7th Ed. 6. Spectrometric Identification of Organic compounds-Silverstein, Bassler, Morrill, 5th Ed., John Wiley & Sons,Inc. 7. Understanding ISO 9000 and implementing the basics to Quality-D.H. Stamatis, Marcel Dekker, Inc. 8. Guidelines for Laboratory Quality Auditing - Donald C. Singer, Ronald P. Upton, Marcel Dekker, Inc. 9. Good Manufacturing Practices for Pharmaceuticals: A plan for total quality control - Sidney H Willing, James R. Stoker, Marcel Dekker, Inc. 10. O.P.P.I. Manual. 11. Good Laboratory Practice Regulations - Ed. by Sandy Weinberg, Marcel Dekker, Inc. 12. Pharmaceutical Analysis: Modern Methods, James W. Munson, Marcel Dekker, Inc. 13. Practical Pharmaceutical Chemistry-I & II, A.H. Beckett and J.B. Stenlake, 4th Ed. CBS Publishers. 14. Indian Pharmacopoeia. 15. British Pharmacopoeia. 16. United States Pharmacopoeia. PH 304 Pharmaceutical Chemistry-V (Medicinal) Theory 3hrs/week 1.Heterolcyclic Compounds: Chemistry, preparations and properties of some important heterocyclics containing 5 and 6 atoms with 1 or 2 hetero atoms like O,N,S and their condensed derivatives (bicyclic only). 2. Basic principles of Medicinal Chemistry: Physico-Chemical aspects (Optical, geometrical and bioisosterism)of drug molecules and biological action, Drug-receptor interaction including transduction mechanisms. 3. Synthetic procedures of official drugs, mode of action (Mechanism of action), uses, structure activity relationship including physicochemical properties of the following class of drugs: A) Drugs acting on Respiratory tract: Anti-asthamatics, Anti-tussives, Expectorants, Analeptics (Respiratory stimulants) B) Drugs acting on Gastro-intestinaltract: Anti-ulcers and Antacids, Anti-Emetics, Pro-Kinetic agents, Antidiarrheals, Laxatives. C) Drugs acting on Autonomic Nervous System: Cholinergics, Anti-cholinergics and Anti-cholinesterases, Adrenergics, Sympatholytics, Neuro-muscular junction blocking agents, D) Drugs acting on Central Nervous System: General Anesthetics, Local Anesthetics, Hypnotics & Sedatives, Opiod analgesics, anti-convulsants, Antiparkinsonism drugs, CNS stimulants Psycho-pharmacological agents (neuroleptics, anti-depressants, anxiolytics). E) Autocoids: Eicosanoids and their Synthesis, inhibitors, NSAID'S., Anti-Allergic drugs (H1-receptor antagonists) 4. Antibiotics: General Chemistry of (-lactum antibiotics, Aminoglycoside antibiotics Tetracyclines, Chloramphenicol, Macrolide antibiotics, Polyene and Pol;ypeptide antibiotics.Hormones: A. Thyroid and Antithyroid drugs. B. Insulin and hypoglycemic agents. C. Steroid hormones: Detailed study of sex hormones and adrenal cortex hormones inaluding synthethic substitutes, SAR in synthetic substitutes. 5. Diagnostic agents. 6. Pharmaceutical aids. NOTE: Biochemical approaches in drug designing wherever applicable should be discussed. PH 304 Pharmaceutical Chemistry-V (Medicinal) Practical 1. Synthesis of selected drug from the course content. 2. Spectral analysis of the drug synthesized. 3. Workshop on stereo model use of some selected drugs. 4. Establishing the pharmacopoeial standards of the drugs synthesized 5. Organic spotting of binary mixtures with derivative preparations and TLC

3hrs/week

Books recommended: 1. Wilson and Gisvold`s Text Book of Organic Medicinal and Pharmaceutical Chemistry. Edited by J.N. Delgado and William A. Remers , J.B. Lippincott Company Philadelphia. 2. Principles of Medicinal Chemistry by W.C. Foye, Lea and Febiger Philadelphia. 3. Bergers Medicinal Chemistry H.E. Wolf , Jhon Wiley and Sons New York Oxford University Press. 4. Organic Chemistry of Drug Synthesis Vol.1-6 by Deniel Lednocer , John Wiley and sons, Inc. New York. 5. Pharmaceutical Substances Synthesis (two parts) ,patents, applications by A. Kleemann, J.Engel by Thieme Stuttgart New York. 6. Organic Chemistry volume 1 & 2 by I.L. Finar publishers ELBS/Longman london. 7. Principles of Medicinal Chemistry by Dr. S. S. Kadam, K.G. Bothara , Nirali Prakashan Pune . 8. Medicinal and Pharmaceutical Chemistry by Harkishan Singh, V.K.Kapoor, Vallabh Prakashan New Delhi. 9. Fundamentals of Drug Metabolism and Disposition by H.N. Ladu, H. G. Mandal and E.L. Way Williams and Wi;kins Co. Baltimore. 10. Vogale`s Text Book of Practical Organic Chemistry, ELBS / Longman, London. 11. Practical Organic Chemistry BY Mann and Saunder. Orient Longman, UK. 12. The Systematic Identification of Organic Compounds byshriner, Hermann,Morrill, Curtin & Fuson, John Wiley and sons , USA. 13. An Introduction to Chemistry of heterocyclic Compounds by R.M. Acheson Wiley Eastern Ltd. New Delhi. 14. Spectrometric identification Of Organic Compounds by R. M. Silverstein, G. Claytorn Bassel`s. T.C. Mivvill. John wiley & Sons, USA. 15. Organic spectropscopy by William Kemp .ELBS, London. PH 305 Pharmacognosy-II Theory 3hrs/week 1. Phytochemical Screeing: (a) Preparation of extracts (b) Screeining of alkaloids, seponins, cardinolides, bufadinolides, flavoinodes, leucoenthocyanidine, tannins, polyphenols, enthroquinones, cynogenitic glycosides ans amino acids in plant extracts. 2. Study of fibers used in pharmacy such as cotton, silk, wool, nylon, glass wool, polyester and asbestos. 3. Study of pharmaceutical aids like talc, diatomite, kaolin, bentonite, gelatin, and natural colors. 4. Study of biological sources, cultivation, collection, commercial varieties, chemical constituents, substitutes, adulterants, uses, diagnostic, macroscopic and microscopic features and specific chemical test of following groups of drugs containing glycosides: (a) Saponins-Liquorice, ginseng, dioscorea, sarsaparilla, and senega. (b) Cardioactive sterols: Digitalis, Squils, Strophenthus, Thevetia. (c) Anthraquinone Cathartics: Aloe, seena, cassia pod, rhubarb and cascara. (d) Others: psorales, ammivisnaga, amimajus, gentian, saffron, chirata, quassia, calmegh, picrorhiza. (e) Glycosids: Chemistry, isolation, estimation and biosynthesis of digitoxin, digoxin, sennosides, diosgenin. 5. Systematic study of source, cultivation, collection, processing, commercial varieties, chemical constituents substitutes, adulterants, uses, diagnostic macroscopic and microscopic features and specific chemical tests of following alkaloids containing drugs: (a) Pyridine-piperidine-tobacco, areca and lobelia. (b) Tropane: belladona, hyoscyamus, datura, duboisia, coca and withania. (c) Quinoline and isoquinoline: cinchona, ipecac, opium, camptotheca. (d) Indol-ergot, rauwolfia, cathoranthus, Nux-vomica and physostigma (e) Imidazole: Pilocarpus (f) Steroidal-kurchi and veratrum. (g) Alkaloidal amine: Ephedra, Colchicum. (h) Glycoalkaloid: solanum. (i) Purines: Coffee, Tea and Cola. (j) Quinozoline: VASAKA (k) Alkaloids: Chemistry and biogenesis and pharmacological activity of atropine and related compounds, quinine reserpine, morphine, papaverine, ephedrine, ergot and vinca alkaloids. 6. Role of medicinal plant and aromatic plants in national economy. 7. Biological source, preparation, identification tests and uses of following enzymes: Diastase, papain, pepsin, trypsin, pancreatin. 8. General techniques of biosynthetic studies and basic metabolic pathways. Brief introduction to biogenesis of secondary metabolites of pharmaceutical importance. 9. Introduction, classification and study of different Chromatographic methods and their applications in evaluation of herbal drugs. 10. Chemical and spectral approaches to simple molecules of natural origin. 11. Concept of stereoisomerism taking example of natural products. 12. Chemistry, biogenesis and pharmacological activity of medicinally important monoterpenes-acyclicgeraniol, monocyclic-limonene, menthone, carvone, bicyclicpinene; sesquiterpenes, B-caryophyllene, borneol;

diterpenes-abietic acid, gibbereltic acid, triterpenoids-sterol-lanosterol, sitosterol, b-amyrin, oleanolic acid, squalene, cholesterol, stigmasterol 13. Carotenoids: beta-carotenoids, alpha-carotenes, vitamin A, Zanthophylis of medicinal importance. 14. Chemistry, isolation, estimation and biogenesis of medicinally important lignans and quassanoids, flavonoids. PH 305 Pharmacognosy-II Practical 3hrs/week 1. Identification of crud drugs mentioned in theory 2. Microscopic study of characters of selected drugs given in the theory in entire and powdered form. 3. Chemical evaluation of powdered drugs and enzymes 4. Laboratory experiments on isolation, separation, purification of various groups of chemical constituents of pharmaceutical significance. Books recommended: 1. Finar I. L. Organic Chemistry Volume-2, Stereochemistry and the Chemistry of Natural Products, 5th Edition1996 ELBS Publication. 2. Dani V. R. Organic Spectroscopy, 1st edition-1995. Tata Mcgraw Hill Publishing Company, New Delhi 3. Morrison, R.T. & Boyd R.N. Organic Chemistry, 6th Edn-1996, Prentice Hall of India Pri. Ltd. New Delhi 4. Chatwal G. Organic Chemistry ofNatural Products, Vol-I and II, 7th Reprint 1998, Himalaya Publishing House, Mumbai 5. Indian Herbal Pharmacopoia, Volume I and II-1999, a Joint publication of IDMA and RRL Jannu Tawi. 6. Trease and Evants-Pharmacognosy, 14th Edition, 1997, W. B. Sounders Company, Singapore 7. Wallis, T. E. Textbook of Pharmacognosy, 5th Edition-1997, CBS Publisher 8. Tyler, Brady, Robberts-Pharmacognosy, 8th Edition-1981, K. M. Varghese Company, Mumbai 9. Sim. S. K. Medicinal Plant Alkaoids and Glycosides, 2nd Edition-1966 University of Toronto Press, Toronto. 10. Cultivation and Utilization of Medicinal Plants, Edited by Atal and Kapur, 1982, RRL Jammu Tawi 11. Cultivation and Utilization of Aromatic Plants, Edited by Atal and Kaur, 1982, RRL Jammu Tawi. 12. Harbone J. B. Phytochemical Methods, 3rd Edition-1998 Champan and Hall London 13. The useful plants of India 3rd reprint 1994 CSIR New Delhi. PH 306 Pharmacology-II (Pharmacology & Pathophysiology) Theory 3hrs/week Pathophysiology: Cell injury and repair mechanism Inflammation Healing Apoptosis & Necrosis. Pathophysiology of various diseases including: CNS disorders: Epilepsy, Parkinsonism, Schizophrenia, Depression Respiratory disease: Asthma Gastrointestinal disorders: Peptic Ulcer, Ulcerative Colitis, Hepatitis, Cirrhosis Infectious diseases: Tuberculosis, urinary tract infection, enteric infections, upper respiratory infections Joint and connective tissue disorders: Rheumatoid arthritis, Gout and Hyperuricemia Neoplastic Diseases: Acute leukemias and Hodgkin's disease Cardiovascular disorders: Hypertension, Angina, Congestive Heart Failure, Myocardial Infraction, Cardiac Arrhythmias and Atherosclerosis. Renal disorders: Acute Renal Failure & Chronic Renal Failure Haematopoietic disorders: Anemia Endocrine: Diabetes mellitus and thyroid disorders Cardiovascular system: Digitalis and cardiac glycosides and other cardiotonics Antihypertensive drugs Anti-anginal and vasodilator drugs including calcium antagonist and -adrenergic antagonist Anti-arrhythmic drugs Drug used in coronary artery disease and hyperlipoprotenemia Drug used in the therapy of shock Drug acting on Haemopoietic system: Hematinics Anticoagulants, Vitamin K and haemostatic agents Fibrinolytic and anti-platelets drug Blood and Plasma Volume expanders Drug acting on urinary system: Fluids and electrolyte balance

 Diuretics Drug acting on respiratory system: Antiasthmatic drugs including bronchodilators Antitussive and expectorants Respiratory stimulants Drug acting on gastrointestinal tract: Antacid anti-secretary and anti-ulcer drugs Laxatives and anti-diarrheal drug Appetite stimulant and suppressant Emetics and anti-emetics Miscellaneous agents Oxidative stress and Antioxidants PH 306 Pharmacology-II Practical 3hrs/week Experiments on isolated preparations: 1. To calculate the PA2 value of Atropine using acetylcholine as an agonist on ileum preparation of rat/guinea pig. 2. To calculate the PA2 value of mepyramine using histamine as an agonist on rat/guinea pig ileum preparation & rat fundus Preparation. Pharmacology of the gastrointestinal tract: 1. To study the anti-secretary and anti-ulcer activity using pylorus legated rats. 2. To study the spasmodic and spasmolytic effect of various drugs on ileum preparation of rats & guinea pig. 3. To find out the unknown drug on ileum preparation of rats/guinea pig. Pharmacology of cardiovascular system: 1. To study the inotropic and chronotropic effects of drugs on frog's heart using stimulated software. 2. To study the effect of various drugs on frogs heart using stimulated software. 3. To demonstrate the effects of various drugs on the B.P. and respiration include the Vasomotor Reversal of Dale and Nicotinic action of acetylcholine using software. Effects of autonomic drugs on rabbit's eye Books recommended: 1. Goyal R.K. Practicals in pharmacology (1994-95) 1st Edn. M/s. B.S.Shah Prakashan, Ahmedabad. 2. Sheth U.K. etal Selected topics in experimental pharmacology (1972) 1st Edn. The Kothari Book Depot, Mumbai. 3. Kulkarni S.K. Handbook of experimental pharmacology(1993) 2nd Edn. Vallabh Prakashan, New Delhi. 4. Ghoosh M.N. Essentials of experimental pharmacology scientific book agency, Culcutta, 1984. 5. Rang. H.P., Dale M.M., etal Pharmacology(1995) 3rd Edn. Churchil livingstone,USA. 6. Satoskar R.S. , etal Pharmacology and pharmacotherapeutics (1999) 16th Edn. Popular Prakashan, Mumbai. 7. Harvel, R.A., Champe P. C. etal, Pharmacology (1997) 2nd edition, Lippincott-Raven Company, Philadelphia, New Yor. 8. Craig C. R. Stitzel, R. E.-Modern Pharmacology (1994) 4th edition. Little Browth and Company, U.S.A. 9. Goodman and Gilmans The Pharmacological Basis of Therapeutics (1996) 9th edition. Pergamon Press, Singapore. 10. Seth S. D., Text Book of Pharmacology, B. I. Churchill, 1997 PH 307 Pharmaceutical Jurisprudence & Ethics Theory 1. Introduction: a. Pharmaceutical Legislation- A brief review b. Drug and Pharmaceuticals Industry A brief review c. Pharmaceutical Education A brief review 2. An elaborate (practical oriented) study of the following: a. Pharmaceutical Ethics b. Pharmacy Act-1948 c. Drugs and Cosmetics Act-1940 and Rules 1945 d. Medicinal and Toilet preparations (Excise Duties) Act- 1955 e. Narcotic Drugs and Psychotropic Substances Act-1985 and rules f. Drug Price Control Order. 3. A brief study of the following with special references to the main provisions: a. Drugs and Magic Remedies (Objectionable Advertisements ) Act-1954 b. Medical Termination of Pregnancy Act-1970 and Rules-1975 c. Prevention of Cruelty to Animals Act-1960 d. States Sops and Establishment Act and Rules e. Insecticides Act-1968

2hrs/week

f. AICTE Act-1987 g. Factories Act-1948 h. Minimum Wages Act-1948 i. Patents Act j. Trade and Merchandise Act k. Industrial Regulation Act (Pollution ) l. Poisons Act-1919 4. A brief study of the various prescriptions/non - prescription products, medical/surgical accessories, diagnostic aids, appliances available in the market. Note: The teaching of all the above acts should cover the latest amendments Books recommended: 1. A Text Book of Forensic Pharmacy by B. M. Mithal, 8th edition. 2. A Text Book of Forensic Pharmacy by N. K. Jain, Vallabh Prakashan 3. The Patent Act-1970 with Patens Rules 1972 4. The Narcotic and Psychotropic Substances Act-1985 with the prevention of illicit traffic in narcotic drugs and psychotropic substances act-1988 along with allied rules and orders-1993. 5. The Medical Termination of Pregnancy Act-1971, along with the medical termination of pregnancy rules1975 6. Insecticides Act-1963 to gather with insecticide rule 1971 and insecticide (Price, Stock, Display and Submission of reports) order-1986 along with selected notifications (5th edition, 1998) 7. The Drugs (Price Control) Order-1987 along with new drug policy-1994 and drugs (Price Control) order-1995 8. The Opium Act-1857 with opium act-1878 and opium and revenue laws act-1950 9. The Standards of Weight and Measures Act-1976 10. The Pharmacy Act-1998 11. The Prevention of Illicit Traffic in Narcotic Drugs and Psychotropic Substances Act-1988 12. The Poisons Act 1999 13. The Minimum Wages Act-1948 14. The Drugs and Cosmetics Act-1940 15. The Medical and Toilet Preparations Act-1955 16. Factories Act-1948 17. Prevention of Cruelty to Animal Act-1960 18. Drugs and Cosmetics Act-1940 by Vijay Malik, 7th edition. 19. Pharmaceutical Jurisprudence by N. K. Jain (Vallabh Prakashan)