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CONTENTS
SECTION 1
Physical pharmacy
1. 2. 3. 4. 5. 6. 7.
States of Matter Micromeretics and Powder Rheology Surface and Interfacial Phenomenon Viscosity and Rheology Dispersion Systems Complexation Kinetics and Drug Stability
SECTION 2
1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18.
Unit operations
Stoichiometry Fluid Flow Heat transfer Evaporation Distillation Drying Size Reduction Mixing Filtration and Centrifugation Crystallization Dehumidification and Humidity Control Refrigeration and Air Conditioning Material of Construction Material Handling Systems Corrosion Plant location Industrial Hazards and Safety Precautions Automated Process Control Systems
SECTION 3
1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14.
Pharmaceutical Technology
Tablets Capsules Micro-encapsulation Parenteral Products Ophthalmic Preparations Pharmaceutical Aerosols Liquid Dosages Forms Semisolid Dosage Forms Suppositories Extraction and Galenical Products Blood Products and Plasma Substitutes Cosmeticology and Cosmetic Preparations Surgical products Packaging of Pharmaceutical Products
SECTION 4
Biotechnology 1. 2. 3. 4. 5. 6. 7. 8. 9. 10.
Importance of microbiology in pharmacy Structure of bacterial cell; Classification of microbes and their taxonomy Identification of Microbes Control of microbes by physical and chemical methods Sterilization Immunology and Immunological Preparations Genetic Recombination Antibiotics Microbial Transformations Enzyme Immobilization
SECTION 5
Biotechnology 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16.
Pharmaceutical Jurisprudence
Pharmaceutical Ethics Pharmacy Act 1948 Drugs and Cosmetics Act 1940 and Rules 1945 Medicinal & Toilet Preparations (Excise Duties) Act 1955 Narcotic Drugs & Psychotropic Substances Act 1985 & Rules Drugs Price Control Order Poisons Act 1919 Drugs and Magic Remedies (Objectionable Advertisements) Act 1954 Medical Termination of Pregnancy Act 1970 & Rules 1975 Prevention of Cruelty to Animals Act 1960 States Shops & Establishments Act & Rules Insecticides Act 1968 AICTE Act 1987 Factories Act 1948 Minimum Wages Act 1948 Patents Act 1970
SECTION 6
1. Pre-formulation studies 2. Stabilization and stability testing
3. ICH Guidelines for stability testing of formulations 4. Performance evaluation methods 5. Bioavailability studies and bioavailability testing 6. GMP and quality assurance, Quality audit 7. Novel Drug delivery System
SECTION 7
1. 2. 3. 4. Biopharmaceutics Pharmacokinetics Clinical Pharmacokinetics Bioavailability and bioequivalence
SECTION 8
1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11.
Inorganic Chemistry
Importance of inorganic compounds in pharmacy and medicine Gastrointestinal Agents Major Intra- and Extra-cellular Electrolytes Essential and Trace Elements Topical Agents Gases and Vapors Dental Products Miscellaneous Agents Pharmaceutical Aids Used in Pharmaceutical Industry Acids, Bases and Buffers Inorganic Radiopharmaceuticals
SECTION 9
Organic Chemistry
1. 2. 3. 4. 5.
Importance of fundamentals of organic chemistry in pharmaceutical sciences Structure and Properties Stereochemistry Stereoselective and stereospecific reactions Structure, Nomenclature, Preparation and Reactions of
6. 7. 8. 9. 10.
SECTION 10
1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13.
Biochemistry
Chemistry of lipids, Carbohydrates and Proteins Biochemistry in pharmaceutical sciences; The concept of free energy Enzymes Co-enzymes The Citric Acid Cycle Lipids Metabolism Biological Oxidation Metabolism of ammonia and nitrogen containing monomers Purine biosynthesis Pyrimidine biosynthesis Biosynthesis of Nucleic Acids Mutation Genetic Code and Protein Synthesis
SECTION 11
1. 2. 3. 4. 5.
Medicinal Chemistry
Basic Principles of Medicinal Chemistry Drug metabolism and Concept of Prodrugs Principles of Drug Design (Theoretical Aspects) Drugs acting on the Autonomic nervous system Drugs acting on the central nervous system
SECTION 12
Pharmaceutical Analysis
Spectroscopy
1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. Basic Spectroscopy Ultraviolet and visible spectrophotometry Infrared spectrophotometry Nuclear Magnetic Resonance spectroscopy Mass Spectrometry (EI & CI only) Flame Photometry Fluorimetry Atomic Emission Spectroscopy Atomic Absorption Spectroscopy X-ray Diffraction Analysis Radioimmunoassay Quality assurance
Chromatography
13. 14. 15. 16. 17. 18. 19. Basic Chromatography TLC HPLC GLC HPTLC Paper Chromatography Column Chromatography
SECTION 13
Physical Chemistry
1. 2. 3. 4. 5. 6. 7. 8. 9.
Importance of basic fundamentals of physical chemistry in pharmacy Behaviour of Gases The Liquid State Solutions Thermodynamics Thermochemical equations; Phase rule; Adsorption Photochemistry Chemical Kinetics Quantum Mechanics
SECTION 14
1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15.
Pharmacology
Fundamentals of general pharmacology Pharmacology of Peripheral Nervous System Pharmacology of Central Nervous System Pharmacology of Cardiovascular System Drugs Acting on the Hemopoietic System Drugs acting on urinary system Autacoids Drugs Acting on the Respiratory System Drugs acting on the Gastrointestinal Tract Pharmacology of Endocrine System Chemotherapy Principles of Toxicology Basic Concepts of Pharmacotherapy Therapeutic Drug Monitoring Concept of Essential Drugs and Rational Drug use
SECTION 15
Pathophysiology
1. Cell Injury and Adaptations 2. Inflammation 3. Immunopathophysiology a. T and B cells, MHC proteins, antigen presenting cells, immune tolerance, pathogenesis of hypersensitivity reactions, autoimmune diseases, AIDS, Amyloidosis 4. Pathophysiology of Common Diseases: a. Depression, Asthma, Peptic ulcer, Ulcerative colitis, Hepatitis, Cirrhosis, Diabetes mellitus and Thyroid disorders, Tuberculosis, Urinary tract infections, Enteric infections, Upper respiratory infections, Anemias, Rheumatic diseases, Gout and Hyperuricemia, Acute Leukaemias, Hodgkin's disease. b. Asthma, diabetes, rheumatoid arthritis, gout, ulcerative colitis, neoplasia, psychosis, depression, mania, epilepsy, acute and chronic renal failure, hypertension, angina, congestive heart failure, atherosclerosis, myocardial
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SECTION 16
Pharmacognosy
1. Sources of Drugs 2. Classification of Drugs 3. Study of medicinally important plants belonging to the families with special reference to: a. Apocynacae, Solanaceae, Rutacease, Umbelliferae, Leguminosae, Rubiaceae, Liliaceae, Graminae, Labiatae, Cruciferae, Papaveraceae; 4. Cultivation, Collection, Processing and Storage of Crude Drugs a. Factors influencing cultivation of medicinal plants, Types of soils and fertilizers of common use. Pest management and natural pest control agents, Plant hormones and their applications, Polyploidy, mutation and hybridization with reference to medicinal plants. 5. Quality Control of Crude Drugs 6. CARBOHYDRATES and derived products a. agar, guar gum acacia, Honey, Isabagol, pectin, Starch, sterculia and Tragacanth; 7. Lipids a. Bees wax, Castor oil, Cocoa butter, Codliver oil, Hydnocarpus oil, Kokum butter, Lard, Linseed oil, Rice, Bran oil, Shark liver oil and Wool fat; 8. RESINS a. Study of Drugs Containing Resins and Resin Combinations like Colophony, podophyllum, jalap, cannabis, capsicum, myrrh, asafoetida, balsam of Tolu, balsam of Peru, benzoin, turmeric, ginger; 9. TANNINS a. Study of tannins and tannin containing drugs like Gambier, black catechu, gall and myrobalan; 10. VOLATILE OILS a. General methods of obtaining volatile oils from plants, Study of volatile oils of Mentha, Coriander, Cinnamon, Cassia, Lemon peel, Orange peel, Lemon grass, Citronella, Caraway, Dill, Spearmint, Clove, Fennel, Nutmeg, Eucalyptus,
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