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Interactions with other patient drugs, OTC or herbal Lab value alterations caused by medicine
medicines (ask patient specifically) May increase ALT, AST, bilirubin, CPK, and alkaline
none phosphatase.
Be sure to teach the patient the following about this
medication
Instruct pt. to take as directed at the same time each day.
Take missed doses as soon as possible unless time for next
dose. Do not stop abruptly; must be decreased gradually.
Encourage pt. and family to be alert for emergence of
anxiety, agitation, panic attacks, insomnia, irritability,
hostility, impulsivity, akathisia, hypomania, mania,
worsening of depression and suicidal idealation, especially
during early antidepressant therapy. If these symptoms,
notify health care professional. May cause drowsiness.
Caution pt. to avoid driving or other activities requiring
alertness until response to medication is known. Advise pt to
consult health care professional prior to taking any Rx, OTC,
or herbal products. Instruct p. to notify healthcare
professional if signs of liver damage (pruritus, dark uring,
jaundice, right upper quadrant tenderness, unexplained “flu-
like symptoms) occur. Advise pt. to avoid taking alcohol
during duloxetine therapy. Instruct pt. to notify health care
professional if pregnancy is suspected.
Dose Range:no pediatric range available because safe use in children/adolescents is not
established. Adult dose range for antidepressant use is 20-30 mg twice daily and for
neuropathic pain is 60 mg once daily.