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RhFactorandABO Incompatibility

Objectives
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Wong:617,619 736740752753 852854.

DefineRHfactorandABOincompatibility. Identifyrelevantprenatalstudies. Identifys/sassociatedwitheach. Discuscommonmedicaltreatmentsfor motherandinfant:rhogam,exchange transfusion,phototherapy. Recognizeappropriatenursingdiagnosisand developaplanofcareforclientswiththese conditions. Identifyemotionalneedsofpatientand family.

Hyperbilirubinemia
n Causedbyanexcessivelevelof

accumulatedbilirubinintheblood n CharacterizedbyJaundice(icterus) n Mostinstancesisrelativelybenign

Whyareweconcerned overHyperbilirubinemia?
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3MajorCategoriesof Jaundice
PhysiologicJaundice

Bilirubinencephalopathy(Kernicterus)

Signs:decreasedactivity,lossofMoro reflex,lethargy,irritability,decreaseinterest infeeding. n Afterseveraldaysrigidextensionof extremities,opisthotonos,fever,seizures, andpossibledeath n Survivorsmaysuffermental retardation,ADHD,delayed/abnormalmotor movement,behaviordisorders,perceptual problems,hearingloss. n Sentinelevent:StrivetoPREVENT!

BreastFeedingAssociated Jaundice

Pathological (HemolyticDiseases)

PhysiologicalJaundice
n Notassociatedwithpathological

JaundiceinBreastfed Infants
n BreastFeedingAssociatedJaundice

process. n Almostallnewbornshaveincreased bililevelsbutaboutdemonstrate s/s. n Thistypeofjaundicecanoccurdueto differencesininfantsproductionand excretionofRBCs

(Earlyonset):begins24days.Related toprocessofbreastfeeding. n BreastMilkJaundice(Lateonset): begins57daysandlevelsmayremain highfor312weeks.

PathologicalJaundice (Hemolytic)
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ABOIncompatibility
MaternalBloodGroup IncompatibleFetal BloodGroup O B A AorB AorAB BorAB

ABOIncompatibility RhIncompatibility

ABOIncompatibility
n Occurswhenthemajorbloodgroup

RhIncompatibility
n RhpositivePresenceofantigen n RhnegativeAbsenceofantigen n Noproblemswithmotherandfetusif

antigensofthefetusaredifferent fromthoseofthemother n Mostcommonisbetweenamother with0bloodandtheinfantwithAorB blood n Mayoccurwithfirstpregnancy!

theyhavethesameRhorifmomis RhpositiveandbabyRhnegative n Undernormalcircumstancesfirstfetus willnotbeharmed.

RHAntigenFormation

RhIncompatibility
nd n 2 pregnancymaternalantibody

entersfetalcirculation
n Destructionoffetalerythrocytesoccur n Fetusaccelerateserythropoiesis n Erythroblastsappearinfetalcirculation n Canleadtoerythroblastosisfetalis

(hydropsfetalis)

ManagementofJaundice
n Prevention n Phototherapy n IntrauterineTransfusion n ExchangeTransfusion

Prevention
InjectionofRhimmuneglobulin(RhoGAM) within72hourspbirthprevents sensitizationintheRhnegwomanwithRh+ baby. n Adm.Standarddosetomother@28weeks gestationasprophylaxis(paminio, miscarriage/abortion,abd.Trauma..) n ConsideredBloodproductprecautions n Suppressesimmuneresponse n SEEMedicationGuide:page617
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Phototherapy

Phototherapy (biliblanket)

Intrauterine/Exchange Transfusions
Intrauterine transfusion: canbedone every2weeks untilPulm maturity n Exchange transfusion: about7585%of bloodexchanged pbabydelivered
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Prenatal PostPartum n Discharge/Home


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