A SEMINAR REpORT ON

" OCULAR MUCOADHESIVE DRUG DELIVERY SYSTEM"

SUBMITTED By

MR. PRITESH V. THAKKAR

M.PHARM SEMESTER-II IN ACADEMIC YEAR

2006-2007

UNDER THE GUIDANCE OF

DR. (MRS.) SUPRIYA S. SHIDHAYE

BHARATI VIDYAPEETH'S COLLEGE OF PHARMACY,
SECTOR-8, C.B.D. BELAPUR, NAVI MUMBAI-400614

CERTIFICATE

This

~s

to

certify
Delivery

that

sem~nar

entitled

"Ocular

Mucoadhesive

Drug

System"

by MR. THAKKAR PRITESH V

being

submitted of M.

~n

partial

fulfillment

of

the ~s year

requirement based on his

at

Pharm, work

Semester-II done in

Curriculum

bonafide
Bharati

The academic
of

2006 -2007 Navi

Vi dyapeeth ' s

College

Pharmacy,

Mumbai,

Under my direct guidance

& supervision.

Place: Navi Mumbai Date:

DR. (MRS.) SUPRIYA S.SHIDHAYE

--~O-

~
Ackno~ledgernent
It was really a golden opportunity to undergo
18t

year M.Phann

Seminar at Bharati Vidyapeeth's College of Pharmacy. I take this opportunity to express out heartfelt gratitude to all the people from the college for inspiring me to go to the depth of the subject through theoretical approach in every stage of my work.

I extend my thanks and respect to Dr. Vilasrao J. Kadam, Principal, Bharati Vidyapeeth's College of Pharmacy, Navi Mumbai; for the

encouragement and facilities provided to us.

Also, I would like to convey my heartfelt thankfulness

to respected

DR. (MRS.)SUPRIYA. SmDHAYE his constant support during the S for course of the seminar.

At last, I would like to extend our gratitude and thankfulness to all of my colleague's and my friends who encouraged me at every step that I took.

(THAKKAR PRITESH V)

OCULAR MUCOADHESIVE DRUG DELIVERY SYSTEM

Contents

1. Introduction

2. Need for Ocular Mucoadhesive Drug Delivery System 3. Anatomy and Physiology of Ocular Globe
4. Theories of Bioadhesion

2 2
4 4

5. Interaction of Mucin and Polymer

6. Factors Important to Mucoadhesion

7 9 9
10

7. Formulation Design 8. Constraints to Ocular Drug Delivery 9. Basic Ingredients 10. Types of Dosage Forms of Ocular Mucoadhesive Drug Delivery System 11. Evaluation 12. Conclusion 13. References

21

30
34

35

OCULAR

M UCOADHESIVE

DRUG

DELIVERY

SYSTEM

INTRODUCTION

[1,2J

Extensive

efforts have recently been focused on targeting region of body for extended

a drug delivery

system in a particular

period of time, not only for

targeting a drug but also for the better control of systemic drug delivery. The concept of mucoadhesion 1980s. was in introduced into the controlled drug delivery area in early

M ucoadhesives: They are synthetic or natural polymers which interact with mucous layer

covering mucosal epithelial surface and mucin molecules constituting a major part of mucus. Bioadhesion: It is defined as ability of a material to adhere to a biological tissue for

extended period of time. Mucoadhesive drug delivery system utilize the property of bioadhesion of

certain water soluble polymers which become adhesive on hydration and hence can be used for targeting drug to a particular region of the body for extended periods of time. The mucosal layer lines number of regions of the body which represent potential sites for attachment of any bioadhesive system and hence the mucoadhesive drug delivery

systems may include following: ~ ~ ~ ~ ~ ~ ~ Buccal delivery system Sublingual delivery system Vaginal delivery system Rectal delivery system Nasal delivery system Ocular delivery system Gastrointestinal delivery system

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