RESVERATROL: Multiple studies indicate t hat this potent anti-oxidant found in red wine has a positive effect on aging,

c ardio-vascular health, and Type II Diabetes Below is an explanation of the effects of RESEVERATROL in general, but i n particular as it applies to Type II Diabetes. Studies and research are cited which indicate that this powerful anti-ox idant has beneficial effects on Type II Diabetes, insulin sensitivity, cardio-va scular health, as well as aging. Free radicals that we're exposed to every day-in sunlight, pollution, ch emicals in our food, water, and more-are one of the root causes of aging and dis ease! Many of the natural metabolic processes in our own bodies generate harmful free radicals. Free radicals are the natural by-product of normal cell metaboli sm and can be thought of like "smoke" produced by the cells in your body, not un like the toxic smoke produced by your backyard grill. Within the body, free radi cals are molecules that need additional oxygen. Free radicals can attack any cel l in the body looking for oxygen, since most cells contain mitochondria, the res piration centers for cells. Free radicals have a propensity for highly vasculari zed tissues in the body such as the internal organs, the eyes, the cardio-vascul ar system, blood vessels, and capillary-rich extremities. When free radicals do attack cells, the cells become compromised, which leads to cell death. Extensive cell death results in tissue damage, pre-mature aging, and even organ failure. Our main defense against free radical damage is anti-oxidants obtained t hrough our diet. Anti-oxidants are only found in plants, particularly the darkly pigmented fruits and vegetables. There are a multitude of studies which prove t hat individuals who consume diets which are rich in anti-oxidants experience dec reased signs of aging and disease. For many years, supplementation with anti-oxi dants has been an accepted and necessary course of treatment in Macular degenera tion. In Macular degeneration, the aim is not to cure or reverse the disease but to slow down the free radical damage in the retina, which hopefully will preven t further vision loss. Certain populations who regularly consume anti-oxidant ri ch foods appear to have lower incidences of cancer, diabetes, cardio-vascular di sease, auto-immune conditions, and many age-related conditions. Chances are you've heard about the French Paradox-you may have even hear d about it when Barbara Walters did an entire segment concerning the paradox on 60 Minutes. The "paradox" is the fact that the French have outstanding heart hea lth, despite their consumption of creamy sauces, croissants, and pastries, not m ention the tremendous amount of smoking by the French as well. Back in 1992, sci entists put their finger on their secret. The French drink red wine with nearly every meal, which is rich in a potent 'super-antioxidant,' called Resveratrol. R esveratrol is a special antioxidant, called a phytoalexin, that's found in the s kins and vines of grapes. Wine grape plants make Resveratrol to defend itself fr om fungal invaders. You can think of it as the plant's natural protective armor, and in many ways that's exactly what it does for your body when you take it. By helping to scavenge and rid your body of those harmful free radicals, Resveratr ol fights aging and disease. Plus, studies have shown that Resveratrol helps com bat another leading cause of aging, inflammation. More recent studies are indica ting that Resveratrol has very exciting implications in Diabetes treatments. No wonder 60 Minutes-and much of the media-are calling Resveratrol a "fountain of y outh" The studies on this potent antioxidant are mounting fast... o Helps to Protect Your Blood Vessels: Preliminary research sugges

ts that Resveratrol may help to protect the walls of your blood vessels against oxidation-which in turn helps to keep your heart, and entire cardiovascular syst em healthy. o Keeps Your Blood Flowing as it Should: Preliminary studies sugge st that the antioxidants in Resveratrol may help to inhibit platelet aggregation , helping to keep your blood flowing as it should. o Supports Healthy Blood Pressure: Animal research suggests that t he wine polyphenols in Resveratrol support healthy blood pressure and healthy bl ood vessel vasodilation-meaning your blood vessels expand and relax as they shou ld. o Supports Brain Function: Preliminary cell and animal research su ggests that Resveratrol may support brain function by alleviating oxidative stre ss. o Promotes Optimal Cellular Health: The polyphenols in Resveratrol are believed to promote optimal cellular health. Resveratrol may also play a ro le in promoting normal cell division. o Helps Stave off Premature Aging: Resveratrol may play a role in alleviating oxidative stress and inflammation that's linked to premature aging. o Promotes Optimal Dental Health: Preliminary research suggests th at Resveratrol may help to promote optimal dental health through its anti-inflam matory properties. Studies and research abstracts concerning Resveratrol and Diabetes Science Daily (October 2008) - Even relatively low doses of Resveratrol-a chemical found in the skins of red grapes and in red wine--can improve the se nsitivity of mice to the hormone insulin, according to a new report. As insulin resistance is often characterized as the most critical factor contributing to th e development of type 2 diabetes, the findings "provide a potential new therapeu tic approach for preventing or treating" both conditions, the researchers said. The research group also confirmed that increased levels of an enzyme called SIRT 1, which earlier studies had linked to longevity, DNA repair, and insulin secret ion, improve insulin sensitivity in mice. Resveratrol is known to activate the S IRT1 enzyme. The results suggest that "red wine might have some benefits for insulin sensitivity, but given the potential complications of drinking alcohol, an even better option may be to find other natural foods enriched with Resveratrol or fo ods supplemented with Resveratrol," he added. Diabetes mellitus, the most common endocrine disorder, currently affects more than 170 million people worldwide and is expected to affect more than 353 million by the year 2030, Zhai said. Type 2 diabetes, which accounts for more th an 90 percent of diabetes cases, is characterized by the resistance of body tiss ues to stimulation by the peptide hormone insulin. Insulin normally lowers blood glucose levels by facilitating the sugar's uptake, mainly into skeletal muscle and fat tissue, and by inhibiting glucose production in the liver. Currently, al leviating insulin resistance is still one of the key avenues to treating type 2 diabetes. Earlier studies had reported a connection between SIRT1 and the processe s of glucose metabolism and insulin secretion. However, whether SIRT1 was direct ly involved in insulin sensitivity remained largely unknown, the researchers sai d. Now, the researchers report that SIRT1 levels are reduced in insulin-resistan

t cells and tissues and that treatments that block the enzyme's function lead to insulin resistance. Furthermore, increased SIRT1 activity improved insulin sens itivity. Similarly, Resveratrol--at a dose of just 2.5 mg/kg/day--enhanced insul in sensitivity in cells. That low dose of Resveratrol also reduced insulin resis tance in animals fed a high-fat diet, the researchers showed. Resveratrol is kno wn to activate a gene called SIRT1, and SIRT1 is linked not only to insulin secr etion, but also to better insulin sensitivity in mice. Other research has found a connection between SIRT1 and glucose metabolism. Researchers have reported tha t insulin resistant disorders like diabetes block normal activation of SIRT1, a factor resulting in the active study of SIRT1 activating compounds, of which Res veratrol in certainly a front runner. "We found SIRT1 improves insulin sensitivity, especially under insulin-resistant conditions," Zhai said. "Furthermore, we found that Resveratrol, at a very low dose compared with many previous studies, improves insulin sensitivity via SIRT1 ." Previously, he noted, the effects of Resveratrol seen in mice had implied tha t humans might need to drink about 120 liters of red wine each day to get enough Resveratrol to enjoy the same benefit. "According to our findings, people might need to drink about three liters of red wine each day to get sufficient Resvera trol--about 15 mg--for its biological effects. But due to the side effects of al cohol ingestion, it is recommended that a liquid form of Resveratrol in a concen trated form would be the better alternative. " The researchers include Cheng Sun, Fang Zhang, Xinjian Ge, Tingting Yan, Xingmia o Chen, Xianglin Shi, and Qiwei Zhai of Institute for Nutritional Sciences, Shan ghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate S chool of the Chinese Academy of Sciences in Shanghai. Resveratrol shows promise as diabetes treatment October 9, 2008 - 6:59am ET Scientists have unveiled yet another study o n the potential of Resveratrol. The chemical, which is found in red wine as well as a variety of plants, has been linked with improved sensitivity to insulin in mouse models, adding another possible therapeutic effect for an ingredient alre ady associated with longevity and DNA repair. Resveratrol activates the SIRT1 en zyme, and researchers at the University of Florida say that could make it a cand idate for treating diabetes. Researchers at U of FL have confirmed earlier repor ts that SIRT1 levels are reduced in insulin-resistant cells and tissues and that treatments that block the enzyme's function lead to insulin resistance. Further more, increased SIRT1 activity improved insulin sensitivity. Similarly, Resverat rol--at a dose of just 2.5 mg/kg/day--enhanced insulin sensitivity in cells. Tha t low dose of Resveratrol also reduced insulin resistance in animals fed a highfat diet, the researchers showed. Central nervous system protection by Resveratrol in streptozotocin-induc ed diabetic rats. Journal of Clinical Neuroscience. 2007 March;14(3):256-60 The aim of this study was to determine the protective role of Resveratro l against high blood glucose levels induced in rats by the drug streptozotocin. This drug is used in medical research to produce an animal model for type 1 diab etes. The researchers found that the administration of Resveratrol offered prote ctive action in the brain and spinal cords because it reduced lipid peroxidation and increased glutathione levels. The study concluded that Resveratrol is a pot ential neuroprotective agent against diabetic oxidative damage. Effect of Resveratrol, a polyphenolic phytoalexin, on thermal hyperalges ia in a mouse model of diabetic neuropathic pain. Fundamental & Clinical Pharmacology. 2007 February;21(1):89-94 Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab U niversity, Chandigarh 160014, India. Diabetic neuropathic pain is a symptom asso

ciated with diabetes mellitus. This condition is the result of injury to small b lood vessels that supply the nerves. Diabetic neuropathic pain is very difficult to treat. The aim of this in vivo study was to determine the effect of Resverat rol on diabetic neuropathic pain. The researchers also measured the effect of Re sveratrol on the serum level of tumor necrosis factor-alpha and whole brain nitr ic oxide release. The tests were carried out on mice treated with streptozotin t o produce an animal model for Type 1 diabetes. The researchers found that an inj ection with Resveratrol significantly and dose-dependently attenuated thermal hy peralgesia, decreased the serum level of tumor necrosis factor-alpha and whole b rain nitric oxide release. They concluded that Resveratrol holds a potential in attenuating diabetic neuropathic pain. Resveratrol improves insulin secretion from rat pancreatic islets. European Journal of Pharmacology. 2006 December 15;552(1-3):176-81 The phytochemical Resveratrol is known to have cardioprotective, antican cer and antioxidant activity but resent research also indicates that Resveratrol may help to alleviate diabetic complications. The aim of this study to determin e the effect of Resveratrol on insulin secretion from incubated pancreatic islet s. The researchers found that Resveratrol increased the release of insulin after being exposed to glucose. They concluded that Resveratrol exerts reversible eff ects on insulin secretion from incubated pancreatic islets. So what do you do? Drink large quantities of red wine? No. The average glass of red wine pr ovides a mere 800 mcg of Resveratrol. Therefore, you would need to drink over 10 0 glasses per day to reach the threshold amounts discussed in the scientific stu dies. The benefits of Resveratrol are obviously negated by the harmful effects o f the alcohol ingestion. A better alternative is to take a supplement containing Resveratrol. Several studies indicate that if the wrong form of Resveratrol is used, it may not be biologically effective. In addition, pills, tablets, and cap sules of Resveratrol are less effective than ingesting a liquid form of Resverat rol. So what are you going to do? Consider drinking MonaVie Pulse! MonaVie PULSE is a nutritional beverage that contains 19 fruits includin g Acai berry, Prickly pear, Bilberry, Apple, Aronia berry, Cranberry, Pineapple, Raspberry, Elderberry, Pomegranate, Tart cherry, Cupuacu, Blueberry, Strawberry , Acerola cherry, Yum berry, Camu-Camu, Concord grape, and Blackberry. This form ula contains plant sterols in such concentration to deliver a therapeutic dose w hich has found to be effective in reducing cholesterol by the FDA and MonaVie ha s been approved as an alternative treatment for lowering cholesterol levels. Mul tiple studies have shown that ingesting 0.8 grams of plant sterols per day is ef fective in lowering cholesterol 8-15%. Two studies recommend adding plant sterol s to one's diet rather than adding additional statin drugs to achieve lower chol esterol levels. One study indicated that there were significantly less side effe cts when using plant sterols as the first line treatment modality in fighting hi gh cholesterol levels. In additional to the cholesterol lowering ability offered by MonaVie Pul se, when Resveratrol is added into the formula, MonaVie Pulse has the added bene fit of cardio-protection, reduced hypertension, improved HDL levels, and decreas ed insulin insensitivity. As quoted in the study abstracts listed above, Resveratrol offers Type II diabet ics unprecedented natural treatment options. The Resveratrol contained in MonaVi e Pulse is a purified, clinically relevant, concentrated amount in liquid form. This liquid Resveratrol is better tolerated and absorbed by most people. Anechtd otal studies indicate that many diabetics have reduced their medications and tre atments after using MonaVie Pulse on a consistent and regular basis.

MonaVie does NOT recommend deviating from current treatments without pro fessional, medical advice, instruction, and direction.MonaVie does NOT recommend or portray any of their products as a treatment, cure, drug, or medication. Mon aVie products are nutritional beverages that incorporate 19 super fruits into a healthy blend of juice. Results will vary from person to person. Please do not d iscontinue medications and/ or treatments without first seeking medical evaluati on and expert medical advice.

Dr. J. Fredrick Litke, is a retired Opto metrist from Henderson, KY who travels and lectures extensively on Nutrition and Health <a href="http://www.humanityspread.com">Find More Info</a>