GAE ELAINE KOVALICK Associate Professor of Biology Department of Biology 2265 University of Texas of the Permian Basin 697-6683

4901 E. University Blvd. kovalick_g@utpb.edu Odessa, Texas 79762 Office telephone: (432) 552Home telephone: (432) Email:

Education University of North Carolina, Chapel Hill Ph.D., Biology, May 1984 Dissertation: "Identification and characterization of juvenile hormone binding proteins in the cockroach Leucophaea maderae." Advisor: J.K. Koeppe Wittenberg University, Springfield, Ohio B.A., Biology, cum laude, June 1980

Professional Work Experience University of Texas of the Permian Basin, Odessa, Texas August 2005-present Associate Professor, Department of Biology University of Texas of the Permian Basin, Odessa, Texas August 1999-2005 Assistant Professor, Department of Science and Mathematics Miami University, Oxford, Ohio 1992-1999 Assistant Professor, Department of Zoology August

Rice University, Houston, Texas August 1988-1992 Research Associate, Department of Biochemistry and Cell Biology Characterized the tissue specific expression of the Drosophila calmodulin gene (Kathleen M. Beckingham, Ph.D., research supervisor)

 Identified a lethal mutation within the calmodulin gene of Drosophila Cloned portions of the upstream flanking region of the Drosophila calmodulin gene into reporter constructs; created transgenic flies with these constructs to identify the gene's regulatory regions Postdoctoral Fellow, Department of Biochemistry and Cell BiologyAugust 1986-1988 Cloned and mapped genomic DNA containing the Drosophila calmodulin gene (Kathleen M. Beckingham, Ph.D., research supervisor) Baylor College of Medicine, Houston, Texas July 19841986 Research Associate, Department of Cell Biology Characterized the hormone binding properties of a putative progesterone binding protein isolated from chicken oviducts (William T. Schrader, Ph.D., research supervisor) University of North Carolina, Chapel Hill August 1981-May 1982 Teaching Assistant, Department of Biology Comparative Vertebrate Anatomy Lab (Kenneth Bynum, Ph.D., supervisor)

Scholarly Works Current Research Interests Function of complex carbohydrates in extracellular matrices Formation, structure, and function of the insect peritrophic matrix Cardia-specific gene regulatory elements in Drosophila melanogaster Publications Books, chapters Koeppe, J.K., and Kovalick, G.E. (1986) Juvenile hormone binding proteins. In: Biochemical Actions of Hormones (G. Litwack, ed.), 13: 265-303. Koeppe, J.K., Fuchs, M., Chen, T.T., Hunt, L.M., Kovalick, G.E., and Briers, T. (1985) The role of juvenile hormone in reproduction. In: Comprehensive Insect Physiology, Biochemistry and Pharmacology (G.A. Kerkut and L.I. Gilbert, eds.) Pergamon Press, New York, 8: 165-203. Prestwich, G.D., Koeppe, J.K., Kovalick, G.E., Brown, J.J., Chang, E.S., and Singh, A.K. (1985) Experimental techniques for photoaffinity labelling of juvenile hormone binding proteins of insects with epoxyfarnesyl diazoacetate (EFDA). Methods Enzymol. 111: 509-530. Koeppe, J.K., Kovalick, G.E., and Prestwich, G.D. (1984) Photoaffinity labelling of juvenile hormone binding proteins in Leucophaea maderae. In: Biosynthesis, Metabolism, and Mode of Action of Invertebrate Hormones (J. Hoffman and M. Porchet, eds.) Springer-Verlag, Berlin, pp.438-443. Koeppe, J.K., Kovalick, G.E., and LaPointe, M.C. (1981) Juvenile hormone interactions with ovarian tissue in Leucophaea maderae. In: Juvenile Hormone Biochemistry (G.E. Pratt and G.T. Brooks, eds.) Elsevier/North Holland Biomedical Press, pp. 215-231. Peer-reviewed publications Kovalick, G.E., and Griffin, D.* (2005) Characterization of the SCP/TAPS gene family in Drosophila melanogaster. Insect Biochemistry and Molecular Biology. 35: 825-835. Megraw, T., Kaufmann, T.C., and Kovalick, G.E. (1998) Sequence and expression of Drosophila Antigen 5-related 2, a new member of the CAP gene family. Gene 222: 297-304. Kovalick, G.E., Schreiber, M.C.*, Dickason, A.K.**, and Cunningham, R.A.**

(1998) Structure and expression of the Antigen 5-related gene of Drosophila melanogaster. Insect Biochem. Mol. Biol. 28: 491-500. Nelson, H.B., Heiman, R.G., Bolduc, C., Kovalick, G.E., Whitley, P., Stern, M., and Beckingham, K. (1997) Calmodulin point mutations affect Drosophila development and behavior. Genetics 147: 1783-1798. Schreiber, M.C.*, Karlo, J.C.*, and Kovalick, G.E. (1997) A novel cDNA from Drosophila encoding a protein with similarity to mammalian cysteine-rich secretory proteins, wasp venom antigen 5, and plant group 1 pathogenesisrelated proteins. Gene 191: 135-141. Heiman, R.G., Atkinson, R.C., Andruss, B.F., Bolduc, C., Kovalick, G.E., and Beckingham, K. (1996) Spontaneous avoidance in calmodulin null Drosophila: An evolutionarily conserved behavioural response? Proc. Natl. Acad. Sci. U.S.A. 93: 2420-2425. Kovalick, G.E., and Beckingham, K.M. (1992) Calmodulin transcription is limited to the nervous system during Drosophila embryogenesis. Dev. Biol. 150: 33-46. Doyle, K.E., Kovalick, G.E., Lee, E., and Beckingham, K. (1990) Drosophila melanogaster contains a single calmodulin gene: Further structure and expression studies. J. Mol. Biol. 213: 599-605. Koeppe, J.K., Prestwich, G.D., Brown, J.J., Goodman, W.G., Kovalick, G.E., Briers, T., Pak, M.D., and Gilbert, L.I. (1984) Photoaffinity labelling of the hemolymph juvenile hormone binding protein of Manduca sexta. Biochemistry 23: 6674-6679. Koeppe, J.K., Kovalick, G.E., and Prestwich, G.D. (1984) A specific photoaffinity label for hemolymph and ovarian juvenile hormone-binding proteins in Leucophaea maderae. J. Biol. Chem. 259: 3219-3223. Prestwich, G.D., Singh, A.K., Carvalho, J.F., Koeppe, J.K., Kovalick, G.E., and Chang, E.S. (1984) Photoaffinity levels for insect juvenile hormone binding proteins: Synthesis and evaluation in vitro. Tetrahedron 40: 529-537. Kovalick, G.E., and Koeppe, J.K. (1983) Assay and identification of juvenile hormone binding proteins in Leucophaea maderae. Mol. Cell. Endocrinol. 31: 271-286. Prestwich, G.D., Kovalick, G.E., and Koeppe, J.K. (1982) Photoaffinity labelling of juvenile hormone binding proteins in the cockroach Leucophaea maderae. Biochem. Biophys. Res. Comm. 107: 966-973.

*Graduate student working under my direction **Undergraduate student working under my direction Manuscripts in revision Kovalick, G.E. Regulation of peritrophic formation and extension after eclosion in Drosophila melanogaster. Submitted to Arthropod Structure and Development

Professional Presentations Abstracts and Presentations at National Meetings Kovalick, G.E. (2008) Initiation and formation of adult type 2 peritrophic matrix. Presented at the 49th Annual Drosophila Research Conference, San Diego, CA. Kovalick, G.E. (2006) Posteclosion regulation of peritrophic matrix formation within the proventriculus. Presented at the 47th Annual Drosophila Research Conference, Houston, TX. Kovalick, G.E., and Griffin, D.L.* (2003) SCP/TAPS gene expression in Drosophila. Dev. Biol. 259: 480. Presented at the 62nd Annual meeting of the Society for Developmental Biology, Boston, MA. Kovalick, G.E., and Schafersman, S.D. (2002) Identification and expression of Drosophila TAPS genes. Presented at the 43rd Annual Drosophila Research Conference, San Diego, CA Kovalick, G.E., and Schafersman, S.D. (2001) Deriving functional and evolutionary relationships from sequence data: Insights from the novel TAPS gene family in four model organisms. Presented at the annual meeting of the Society for the Study of Evolution, Knoxville, TN. Dickason, A.K.*, Nathan, J.E.**, and Kovalick, G.E. (1999) Regulation of morphological and functional changes in the Drosophila midgut following eclosion. Dev. Biol. 210: 198. Presented at the 58th annual Society for Developmental Biology meeting, Charlottesville, VA. Kovalick, G.E., and Jay, R.C.** (1999) The effects of Antigen 5-related and Antigen 5-related 2 gene deletion on the structure and function of the Drosophila larval midgut. Dev. Biol. 210: 209. Presented at the 58th annual Society for Developmental Biology meeting, Charlottesville, VA.

Kovalick, G., Brown, C.**, Jay, R.**, and Nathan, J.** (1998) Regulation and function of the Antigen 5-related (Agr) gene within the proventriculus. Presented at the 39th annual Drosophila Research Conference, Washington, DC. Kovalick, G., and Zhang, J.* (1998) Regulation of Antigen 5-related 2 gene expression within the posterior midgut. Presented at the 39th annual Drosophila Research Conference, Washington, DC. Megraw, T., Kovalick, G., and Kaufman, T. (1997) Identification and characterization of Antigen 5-related 2, a gene that, unlike the Agr homolog, is expressed in the embryonic and larval tracheal system. Presented at the 38th annual Drosophila Research Conference, Chicago, IL. Kovalick, G., Zhang, J.*, Cunningham, R.**, Hubbard, M.**, Dahl, J.**, and Bantz, J.** (1997) The role of the Antigen 5-related gene in development of the adult midgut and ovaries. Presented at the 38th annual Drosophila Research Conference, Chicago, IL. Kovalick, G., and Karlo, C.* (1996) Changes in the levels of antigen 5related RNA in larvae and adults during the immune response. Presented at the 37th annual Drosophila Research Conference, San Diego, CA. Kovalick, G., Claussen, W.**, and Schreiber, M.* (1996) Structure, localization, and complete coding sequence of the antigen 5-related gene. Presented at the 37th annual Drosophila Research Conference, San Diego, CA. Kovalick, G.E., Karlo, J.C.*, and Schreiber, M.C.* (1995) Changes in expression of Drosophila agr RNA during development and immune challenge. Presented at the annual meeting of the American Society for Cell Biology, Washington, D.C. Kovalick, G., Clarke, J.*, and Schreiber, M.* (1995) Expression of an RNA from Drosophila encoding a protein with sequence similarity to venom peptides from wasps and ants. Presented at the 36th annual Drosophila Research Conference, Atlanta, GA. Schreiber, M.C.*, and Kovalick, G.E. (1995) Sequence analysis and RNA expression of a Drosophila cDNA encoding a protein with homology to insect venom peptides. Am. Zool. 34(5): 66A Schreiber, M.*, Harmon, B.**, Iesulauro, A.**, Moran, A.**, Lacy, J.**, Garg, S.**, and Kovalick, G. (1994) Isolation and partial characterization of a Drosophila cDNA with sequence similarity to the farnesyl transferase subunit of yeast and rat. Presented at the 35th Annual Drosophila Research Conference, Chicago, IL

Beckingham, K., Kovalick, G.E., Bolduc, C., Heiman, R., Gamse, J., and Andruss, B.F. (1993) A role for calmodulin in Drosophila embryo dorsalventral patterning. Int. Congr. Genet. 17: 179. Kovalick, G., and Beckingham, K. (1991) Activation of zygotically-derived calmodulin transcription is limited to the presumptive nervous system during embryogenesis. Presented at the 32nd Annual Drosophila Research Conference, New Orleans, LA Kovalick, G., Doyle, K., and Beckingham, K. (1989) An additional 5' exon in the single calmodulin gene of D. melanogaster. Presented at the 30th Annual Drosophila Research Conference, Chicago, IL Koeppe, J.K., and Kovalick, G.E. (1982) Juvenile hormone binding proteins in Leucophaea maderae. J. Cell. Biochem. 6 (suppl.): 156. Kovalick, G.E., and Koeppe, J.K. (1982) A specific photoaffinity label for juvenile hormone binding proteins in Leucophaea maderae. Am. Zool. 22: 976. Prestwich, G.D., Koeppe, J.K., Kovalick, G.E., Singh, A.K., and Carvalho, J.F. (1982) Photoaffinity labelling of cockroach JH binding proteins. Am. Chem. Soc., Proceedings. *Graduate student working under my direction **Undergraduate student working under my direction Abstracts and Presentations at Regional Meetings Kovalick, G.E., and Koeppe, J.K. (1983) Juvenile hormone binding proteins in Leucophaea maderae. North Carolina Scientist. Invited Seminars/Presentations The Genetic Control of Differentiation in the Fruit Fly Drosophila. Wittenberg University Seminar Series, Springfield, OH, October, 1997. The Drosophila Antigen 5-related Protein: A Venom in Fruit Flies? Wright State University Seminar Series, Dayton, OH, February, 1996. The Role of Lipid-Modified Proteins in the Regulation of Cell Function. Miami University, Department of Chemistry Seminar Series, Oxford, OH, September, 1993.

 Regulation and Expression of the Calmodulin Gene in Drosophila melanogaster. Miami University, Department of Microbiology Seminar Series, Oxford, OH, October, 1992. Invited speaker, Roundtable discussion, Insect Hormone Receptors, Satellite Symposium, 10th International Symposium on Comparative Endocrinology, Fort Collins, CO, July, 1985.

Teaching Responsibilities Course taught Biology 1306 General Biology I lecture Fall 1999, Spring 2000, Spring 2002, Spring 2003, Fall 2003, Spring 2004, Fall 2004, Spring 2005, Fall 2005, Spring 2006 Biology 1106 General Biology I laboratory Fall 1999, Spring 2000, Spring 2002 Biology 1308 Biology for Non-Science Majors Spring 2008, Fall 2008 Biology 3350 Human Anatomy lecture Fall 2002-Fall 2009 Biology 3151 Human Anatomy laboratory Fall 2002, Fall 2004-2009 Biology 3352 Human Physiology lecture Spring 2001-2010 Biology 3153 Human Physiology laboratory Spring 2001-2003, Spring 2007, Spring 2009-2010 Biology 4330 Developmental Biology lecture Spring 2000, Spring 2002, Spring 2004, Spring 2006 Biology 4340 Genetics lecture Fall 2000, Fall 2001, Fall 2004, Spring 2005-2010 Biology 4141 Genetics laboratory Fall 2000, Fall 2001, Fall 2004, Spring 2006, Spring 2009 Biology 4350 Fall 1999-2003 Biology 4151 Fall 1999-2002 Comparative Vertebrate Anatomy lecture Comparative Vertebrate Anatomy laboratory

Biology 6345 Developmental Biology Fall 2007, Fall 2009

Advising Major advisor for 55 undergraduate students Thesis advisor for 2 graduate students Thesis committee member for one graduate student Professional Service Divisional/University-wide service 1999-2002 University Grant Development Review Panel members review proposals for internal funding 2000-present Health Professions Advisory Committee conducts mock interviews for medical and dental school applicants 2000-2003 Faculty Senate 2009-present represents the Department of Science and Mathematics, Biology reviews curriculum changes recommends changes in University policy elected position Executive Council member Chair, General Education Oversight Committee 2001-present Admissions Committee reviews admissions procedures and criteria reviews undergraduate applicant files for provisional or probationary admissions 2002-present Campus Building Use & Construction Committee makes recommendations on campus building use and construction 2004-2007 College of Arts and Sciences Curriculum Committee reviews changes in courses and curricula Chair of the committee in the 2006-2007 academic year 2008-present Institutional Biosafety Committee Reviews research that involves work with recombinant DNA 2009-present College of Arts and Sciences Promotion and Tenure Committee reviews progress of probationary faculty makes recommendations for tenure and promotion

 elected position Professional Memberships American Association for the Advancement of Science Genetics Society of America Society for Developmental Biology

Grants Funded November 2008 Cloning and characterization of two chitin synthase genes in Drosophila Faculty mentor Louis Stokes Alliance for Minority Participation $500 stipend, $500 to support the student project Student stipend to support undergraduate research October 2008 Enhancing genetic research using the model organism Drosophila Principal Investigator Faculty Development Fund for Academic Excellence $3000 for dissecting microscope and fiber optic illuminator November 2005 Regulation of Adult Maturation in the Fruit Fly, Drosophila Principal Investigator Faculty Development Fund for Academic Excellence/Provosts Research Enhancement Funds $8578 for equipment and supplies June 2005 Principal Investigator LERR $6000 for equipment Principal Investigator Grant Incentive Award, UT Permian Basin $1500 for supplies

July 2004

September 2003 Male Fertility as Studied in the Drosophila Model $9000 salary/wages for student assistant September 2002 Male Fertility as Studied in the Drosophila model Principal Investigator State of Texas Research Enhancement Award Grant proposal development $14,000 salary/wages for student assistant $4000 laboratory supplies $3500 travel March 2002 Male Fertility as Studied in the Drosophila model Principal Investigator State of Texas Research Enhancement Award Grant proposal development

 June 2001 Hybridization

$5000 $4000 $2000 $9100

salary/wages for student assistants laboratory supplies travel equipment

Embedding and Sectioning Drosophila Tissues for In Situ Faculty Mentor University of Texas Medical Branch at Galveston $4100 for supplies and stipends project for area high school teacher and student

June 2001 Drosophila

Characterization of the B118 Mutation in the Fruit Fly Faculty Mentor Louis Stokes Alliance for Minority Participation $1000 for supplies Student stipend to support undergraduate engaged in

research January 2001 Drosophila Participation $500 for supplies Student stipend to support undergraduate engaged in research May 2000 Classroom Promoting Active Learning in the Introductory Biology Characterization of the B118 Mutation in the Fruit Fly Faculty Mentor The University of Texas System Alliance for Minority

UTPB Instructional Development Committee $400 to attend NSF-sponsored short course on instructional methods March 2000 in the Fruit Fly The Identification of Genes Involved in Adult Development Drosophila melanogaster Principal Investigator UTPB Office of Sponsored Research $1500 for supplies

December 1999 Isolation, Cloning, and Sequencing of Agr cDNAs from the Horn Fly Haematobia irritans Faculty Mentor The University of Texas System Alliance for Minority Participation $600 for supplies

research Grants pending

student stipend to support undergraduate engaged in

November 2009 Identification and characterization of cardia-specific genes in Drosophila melanogaster Principal Investigator Faculty Development Fund for Academic Excellence $4000 Requested January 2010 and Function Role of Chitin in Type 2 Peritrophic Matrix Structure Principal Investigator National Science Foundation $444,608 Requested