BRANDNAME Thorazine (zycloran)

GENERIC NAME Chlorpromazine

DRUG CLASS Antipsychotics

MECH. OF ACTION

INDICATION Acute and chronic psychoses, particularly when accompanied by increased psychomotor activity. Nausea and vomiting. Also used in the treatment of intractable hiccups.

CONTRAINDICATION

ADVERSE EFFECT

NSG. RESPONSIBILITY
Assess mental status prior to and periodically during therapy. Monitor BP and pulse prior to and frequently during the period of dosage adjustment. May cause QT interval changes on ECG. Observe patient carefully when administering medication, to ensure that medication is actually taken and not hoarded. Monitor I&O ratios and daily eight. Assess patient for signs and symptoms of dehydration. Monitor for development of neuroleptic malignant syndrome (fever, respiratory distress, tachycardia, seizures,

Block dopamine receptors in the brain; also alter dopamine release and turnover. Prevention of seizures

CNS: neuroleptic malignant syndrome, sedation, extrapyramidal reactions, tardive dyskinesia CV: hypotension (increased with IM, IV) EENT: blurred vision, dry eyes, lens opacities GI: constipation, dry mouth, anorexia, hepatitis, ileus GU: urinary retention Hematologic: agranulocytosis, leukopenia Skin: photosensitivity, pigment changes, rashes

Hypersensitivity. Cross-sensitivity may exist among phenothiazines. Should not be used in narrowangle glaucoma. Should not be used in patients who have CNS depression.

diaphoresis, hypertension or hypotension, pallor, tiredness, severe muscle stiffness, loss of bladder control. Report symptoms immediately. May also cause leukocytosis, elevated liver function tests, elevated CPK.

Zoloft

Setraline Hydrochloride

Anti-depressant

Acts as an antidepressant by inhibiting CNS neuronal uptake of serotonin; blocks uptakeof serotonin with little effect on norepinephrine, muscarinic, histaminergic, and alpha1-adrenergic or dopaminergic receptors.

Treatment of major depressive disorder Treatment of obsessivecompulsive disorders (OCD) Treatment of panic disorder with or without agoraphobia Treatment of posttraumatic stress disorder; long-term use to prevent relapse and sustain symptom improvement

Contraindicated with hypersensitivity to sertraline. Use cautiously with impaired hepatic or renal function, lactation, pregnancy

CNS: Headache, nervousness, drowsiness, anxiety, tremor, diz ziness, insomnia, light-headedness, agitation,sedation, abnormal gait, seizures, vision changes, fatigue CV:Hot flashes, palpitations, chest pain Dermatologic:Swe at ing, rash, pruritus, acne, contact dermatitis GI: Nausea,vomiti

History: Hypersen sitivity to sertraline; impaired hepatic or renal function; lactation, pregnancy Physical: Weight; T; skin rash, lesions; reflexes, affect; bowel sounds, liver evaluation; P, peripheral perfusion; urinary output, renal and liver function tests

Treatment of premenstrual dysphoric disorder (PMDD)

Treatment of social anxiety disorder (social phobia)

ng, diarrhea, dry mouth, anorexia, dyspepsia, constipation, taste changes, flatulence, gastroenteritis, dysphagia, gingivitis GU: Painful menstruation, sexu al dysfunction, frequency, cystitis, impotence, urgency, vaginitis Respiratory: Uppe r respiratory infections, pharyngitis, cough, dyspnea, bronchitis,rhinit is