Pathogenic fungi are fungi that cause disease in humans or other organisms.

The study of pathogenic fungi is referred to as medical mycology. Although fungi are eukaryotic organisms many pathogenic fungi are also microorganisms.[1]
Contents
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1 Candida 2 Aspergillus 3 Cryptococcu s 4 Histoplasma 5 Pneumocyst is 6 Stachybotry s 7 Drug resistance 8 Endothermy 9 See also 10 External Links 11 References

[edit]Candida

Candida. Pap test specimen. Pap stain.

Candida species are important human pathogens that are best known for causing opportunist infections in immunocompromised hosts (e.g. transplant patients, AIDS sufferers, cancer patients). Infections are difficult to treat and can be very serious: 30-

40% of systemic infections result in death.[citation needed] The sequencing of the genome of C. albicans and those of several other medically-relevant Candida species has provided a major impetus for Candida comparative and functional genomic analyses. These studies are aiding the development of sensitive diagnostic strategies and novel antifungal therapies.[2] [edit]Aspergillus

Aspergillosis. H&E stain.

Aerosolized Aspergillus spores are found nearly everywhere so we are routinely and almost constantly exposed to them. Such exposure is a normal part of the human condition and generally poses no adverse health effects. Nevertheless, Aspergillus can and does cause disease in three major ways: through the production of mycotoxins; through induction of allergenic responses; and through localized or systemic infections. With the latter two categories, the immune status of the host is pivotal. Allergies and asthma are thought to be caused by an active host immune response against the presence of fungal spores or hyphae. In contrast, with invasive aspergillosis, the immune system has collapsed and little or no defence can be mounted.[3] The most common pathogenic species are Aspergillus fumigatus and Aspergillus flavus. Aspergillus flavus produces aflatoxin which is both a toxin and a carcinogen and which can potentially contaminate foods such as nuts. Aspergillus fumigatus and Aspergillus clavatus can cause allergic disease. SomeAspergillus species cause disease on grain crops, especially maize, and synthesize mycotoxins including aflatoxin. Aspergillosis is the group of diseases caused by Aspergillus. The symptoms include fever, cough, chest pain or breathlessness. Usually, only patients with weakened immune systems or with other lung conditions are susceptible.[1][3]:) [edit]Cryptococcus

Cryptococcus. FNA specimen. Field stain.

Cryptococcus neoformans can cause a severe form of meningitis and meningoencephalitis in patients with HIV infection and AIDS. The majority ofCryptococcus species live in the soil and do not cause disease in humans. Cryptococcus neoformans is the major human and animal pathogen.Cryptococcus laurentii and Cryptococcus albidus have been known to occasionally cause moderate-to-severe disease in human patients with compromised immunity. Cryptococcus gattii is endemic to tropical parts of the continent of Africa and Australia and can cause disease in non-immunocompromised people.[1] [edit]Histoplasma

Histoplasmosis. PASD stain.

Histoplasma capsulatum can cause histoplasmosis in humans, dogs and cats. The fungus is most prevalent in the Americas, India and southeastern Asia. It is endemic in certain areas of the United States. Infection is usually due to inhaling contaminated air. [edit]Pneumocystis Pneumocystis jirovecii (or Pneumocystis carinii) can cause a form of pneumonia in people with weakened immune systems, such as premature children, the elderly, and AIDS patients.[4]

[edit]Stachybotrys Stachybotrys chartarum or "black mold" can cause respiratory damage and severe headaches. It frequently occurs in houses in regions that are chronically damp. [edit]Drug

resistance

Treatment with antifungal drugs often results in the appearance of resistant strains of fungi. Various mechanisms leading to resistance have been described. For example, a number of resistant clinical isolates overexpress genes encoding drug efflux pumps. Recent advances in molecular biology have allowed the study of the phenomenon of multi-drug resistance on a genome-wide scale. DNA microarrays are being used to study the expression profiling of pathogenic fungi and proteomics is aiding research in the development of resistance to various antifungal drugs. [5] [edit]Endothermy Mammalian endothermy and homeothermy are potent nonspecific defenses against most fungi.[6] [edit]See

also

Mycology Microbiology

[edit]External

Links

Interactive Science Experiments Showcasing the Growth of Fungal Diseases over time.

[edit]References
1. ^ a b c San-Blas G; Calderone RA (editors). (2008). Pathogenic Fungi: Insights in
Molecular Biology. Caister Academic Press. ISBN 978-1-904455-32-5. [1].

2. ^ dEnfert C; Hube B (editors). (2007). Candida: Comparative and Functional Genomics.

Caister Academic Press. ISBN 978-1-904455-13-4. [2].

3. ^ a b Machida, M; Gomi, K (editors) (2010). Aspergillus: Molecular Biology and

Genomics. Caister Academic Press. ISBN 978-1-904455-53-0.

4. ^ Ryan KJ; Ray CG (editors) (2004). Sherris Medical Microbiology (4th ed.). McGraw
Hill. ISBN 0838585299.

5. ^ Waldin et al. (2008). "Genome-wide Approaches to Understand Multi-drug Resistance

in Pathogenic Fungi". Pathogenic Fungi: Insights in Molecular Biology. Caister Academic Press.doi:[http://www.horizonpress.com/pat2 ISBN 978-1-904455-32-5].

6. ^
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v d e

Infectious diseases Mycoses and Meso

Superficial and cutaneous (dermatomycosis): Tinea=skin; Piedra (exothrix/ endothrix)=hair

Ascomycota

Dermatophyte (Dermatophytosis)

Tinea barbae/Tinea capitis (Kerion) T By locationunguium/Onychomycosis (White supe Tinea corporis gladiatorum Tinea fac

Epidermophyton floccosum Microspo By organism tonsurans Trichophyton schoenleini

OtherHortaea werneckii (Tinea nigra) Piedraia hortae (Black

BasidiomycotaMalassezia furfur (Tinea versicolor, Pityrosporum folliculitis) Trichosporon spp (W

Dimorphic (yeast+mold)

Coccidioides immitis/Coccidioides posad pulmonary coccidioidomycosis) Histop Onygenales disseminated histoplasmosis) Histoplas brasiliensis (Paracoccidioidomycosis)

Ascomycota

Blastomyces dermatitidis (Blastomycosis Other marneffei (Penicilliosis)

Candida albicans (Candidiasis, Oral, Esophageal, Vulvova Yeast-likeparonychia, Candidid, Diaper candidiasis, Congenital cutan tropicalis C. lusitaniae Pneumocystis jirovecii (Pneumoc Subcutaneous, systemic, and opportunistic

Aspergillus (Aspergillosis, Aspergilloma, Allergic broncho Mold-like pedrosoi/Fonsecaea compacta/Phialophora verrucosa (Ch

BasidiomycotaCryptococcus neoformans (Cryptococcosis), Trichosporon spp (Trichosporono

Zygomycota (Zygomycosis)

Mucorales Rhizopus oryzae Mucor indicus Absidia c (Mucormycosis)

Entomophthorales Basidiobolus ranarum (Basidiobolomycosis (Entomophthoramycosis)

Microsporidia Enterocytozoon bieneusi/Encephalitozoon intestinalis (Microsporidiosis) Mesomycetozoea Ungrouped Rhinosporidium seeberi (Rhinosporidiosis)

Alternariosis Fungal folliculitis Fusarium (Fusariosis) Granuloma gluteale infantum Hyalohyphomy

M: MYC

fung, clas