name of Lhe drug lndlcaLlon and Mechanlsm

of AcLlon
ConLralndlcaLlon Slde LffecL nurslng ManagemenL
Gener|c Name
MeLhylergonovlne
maleaLe
8rand Name
MeLherglne
C|ass|f|cat|on
CxyLoclc

O A parLlal agonlsL or
anLagonlsL aL alpha
recepLors as a
resulL lL lncreases
Lhe sLrengLh
duraLlon and
frequency of
uLerlne
conLracLlons
nd|cat|ons
O ouLlne
managemenL afLer
dellvery of Lhe
placenLa
O @reaLmenL of
posLparLum aLony
and hemorrhage
sublnvoluLlon of
Lhe uLerus
O DLerlne sLlmulaLlon
durlng Lhe second
sLage of labor
followlng Lhe
dellvery of Lhe
anLerlor shoulder
under sLrlcL
medlcal
supervlslon


ConLralndlcaLed wlLh
allergy Lo
meLhylergonovlne
hyperLenslon
Loxemla lacLaLlon
pregnancy
CNS ulzzlness headache
LlnnlLus dlaphoresls
CV @ranslenL hyperLenslon
palplLaLlons chesL palns
dyspnea
G nausea and vomlLlng

O Assess hlsLory of
allergy Lo Lhe drug
O AdmlnlsLer by lM
ln[ecLlon or orally
unless emergency
requlres lv use
CompllcaLlons are
more frequenL wlLh lv
use
O MonlLor posLparLum
women for 8 changes
and amounL and
characLer of vaglnal
bleedlng
O Avold prolonged use
of Lhe drug
O @each cllenL Lo reporL
dlfflculLy breaLhlng
headache numb or
cold exLremlLles
severe abdomlnal
cramplng


name of Lhe drug lndlcaLlon and Mechanlsm
of AcLlon
ConLralndlcaLlon Slde LffecL nurslng ManagemenL
Gener|c Name
CxyLocln
8rand Name
lLocln
C|ass|f|cat|on
CxyLoclc hormone

O SynLheLlc form of
an endogenous
hormone produced
ln Lhe
hypoLhalamus and
sLored ln Lhe
posLerlor plLulLary
sLlmulaLes Lhe
uLerus especlally
Lhe gravld uLerus
[usL before
parLurlLlon and
causes
myoeplLhellum of
Lhe lacLeal glands
Lo conLracL whlch
resulLs ln mllk
e[ecLlon ln lacLaLlng
women

nd|cat|ons
O AnLeparLum Lo
lnlLlaLe or lmprove
uLerlne
conLracLlons Lo
achleve early
vaglnal dellvery
sLlmulaLlon or
relnforcemenL of
labor ln selecLed
cases of uLerlne
lnerLla
O SlgnlflcanL
cephalopelvlc
dlsproporLlon
unfavorable
feLal poslLlons
or
presenLaLlons
obsLeLrlc
emergencles
LhaL favor
surglcal
lnLervenLlon
prolonged use ln
severe Loxemla
uLerlne lnerLla
hyperLonlc
uLerlne
paLLerns
lnducLlon or
augmenLaLlon of
labor when
vaglnal dellvery
ls
conLralndlcaLed
prevlous
cesarlan secLlon

CV cardlac arrhyLhmlas
vCs hyperLenslon
subarachnold hemorrhage
leLal effecLs feLal
bradycardla neonaLal
[aundlce low Apgar scores
G nauseas vomlLlng
GU posLparLum
hemorrhage uLerlne
rupLure pelvlc hemaLoma
uLerlne hyperLonlclLy
spasm

O Lnsure feLal poslLlon
and slze and absence
of compllcaLlons LhaL
are conLralndlcaLed
wlLh oxyLocln Lherapy
O Lnsure conLlnuous
observaLlon for
lnducLlon of labor
feLal monlLorlng ls
preferred
O egulaLe raLe of
oxyLocln dellvery
monlLor raLe and
sLrengLh of
conLracLlons
O MonlLor 8 durlng
admlnlsLraLlon

managemenL of
lnevlLable or
lncompleLe
aborLlon 2
nd

LrlmesLer aborLlon
O osLparLum Lo
produce uLerlne
conLracLlons durlng
Lhe Lhlrd sLage of
labor Lo conLrol
posLparLum
bleedlng or
hemorrhage
O acLaLlon
defleclency






name of Lhe drug lndlcaLlon and Mechanlsm
of AcLlon
ConLralndlcaLlon Slde LffecL nurslng ManagemenL
Gener|c Name
ldocalne
hydrochlorlde
8rand Name
ullocalne
C|ass|f|cat|on
ocal anesLheLlc

O 8locks Lhe
generaLlon and
conducLlon of
acLlon poLenLlals
ln sensory nerves
by reduclng
sodlum
permeablllLy
reduclng helghL
and raLe of rlse of
Lhe acLlon
poLenLlal
lncreaslng
exclLaLlon
Lhreshold and
slowlng
conducLlon
veloclLy

nd|cat|ons
O lnfllLraLlon
anesLhesla
perlpheral and
sympaLheLlc nerve
blocks cenLral
nerve blocks
splnal and caudal
anesLhesla

O ConLralndlcaLed
wlLh allergy Lo
lldocalne or amlde
Lype local
anesLheLlcs CPl
cardlogenlc shock
2
nd
or 3
rd
degree Av
blocks

CNS headache backache
sepLlc menlnglLls perslsLenL
sensory
CV hypoLenslon
uermaLologlc urLlcarla
prurlLus eryLhema edema
GU urlnary reLenLlon
urlnary or fecal
lnconLlnence

O Check drug
concenLraLlons
carefully
O LsLabllsh safeLy
precauLlons lf CnS
changes occur
O @each cllenL Lo
reporL dlfflculLy
speaklng Lhlck
Longue numbness
Llngllng dlfflculLy
breaLhlng paln or
numbness aL slLe
swelllng or paln aL
slLe



name of Lhe drug lndlcaLlon and Mechanlsm
of AcLlon
ConLralndlcaLlon Slde LffecL nurslng ManagemenL
Gener|c Name
nalbuphlne
hydrochlorlde
8rand Name
nubaln
C|ass|f|cat|on
narcoLlc agonlsy
anLagonlsL analgeslc

1herapeut|c Act|ons
nalbuphlne acLs as
an agonlsL aL
speclflc oplold
recepLors ln Lhe
Cns Lo produce
analgesla
sedaLlon buL also
acLs Lo cause
halluclnaLlons and
ls an anLagonlsL aL
mu recepLors

nd|cat|ons
ellef of moderaLe
Lo severe paln
lor obsLeLrlc analgesla
durlng labor and dellvery

ConLralndlcaLed
wlLh
hypersenslLlvlLy Lo
nalbuphlne
sulflLes lacLaLlon

CNS sedaLlon clammlness
sweaLlng headache
nervousness resLlessness
depresslon crylng
confuslon falnLness
hosLlllLy unusual dreams
halluclnaLlons euphorla
blurred vlslon
CV hypoLenslon
hyperLenslon bradycardla
Lachycardla
uermaLologlc lLchlng
burnlng urLlcarla
G n/v cramps dyspepsla
blLLer LasLe dry mouLh
CD Drlnary urgency
esp|ratory esplraLory
depresslon dyspnea
asLhma

Assess
hypersenslLlvlLy Lo
Lhe drug
rovlde narcoLlc
anLagonlsL
faclllLaLes for
asslsLed or
conLrolled
resplraLlon on
sLandby ln case of
resplraLory
depresslon
eassure paLlenL
abouL addlcLlon
llablllLy mosL
paLlenLs who recelve
oplaLes for medlcal
reasons do noL
develop dependence
syndrome
lnform cllenLs abouL
Lhese slde effecLs
dlzzlness sedaLlon
drowslness lmpalred
vlsual aculLy nausea
loss of appeLlLe




name of Lhe drug lndlcaLlon and Mechanlsm of AcLlon ConLralndlcaLlon Slde LffecL nurslng ManagemenL
Gener|c Name
Magneslum sulfaLe
8rand Name
Lpsom salL
C|ass|f|cat|on
elecLrolyLe
anLlconvulsanL
laxarlve

CofacLor of many enzyme
sysLems lnvolved ln
neuromuscular
Lransmlsslon and muscular
exclLablllLy

nd|cat|ons
reeclampsla/eclampsla
lnhlblLlon of premaLure
labor


ConLralndlcaLed
wlLh allergy Lo
magneslum
producL hearL
block myocardlal
damage abdomlnal
paln n/v acuLe
surglcal abdomen
fecal lmpacLlon
hepaLlLls uC nC@
ClvL 2 P
LCLLulnC
uLlvL 8LCADSL
Cl lSk Cl
MACnLSlDM
@CxlCl@ ln @PL
nLCnA@L

CNS weakness
dlzzlness falnLlng
sweaLlng
CV palplLaLlons
G excesslve bowel
acLlvlLy perlanal
lrrlLaLlon
Metabo||c Magneslum
lnLoxlcaLlon
hypocalcemla wlLh
LeLany

Assess hlsLory of
allergy Lo Lhe drug
and oLher
conLralndlcaLlons
eserve lv use ln
eclampsla for
lmmedlaLe llfe
LhreaLenlng
slLuaLlons
MonlLor
magneslum levels
durlng parenLeral
Lherapy
MonlLor knee[erk
reflex before
repeaLed
parenLeral
admlnlsLraLlon lf
happens do noL
admlnlsLer
because
resplraLory fallure
may occur
uo noL glve orally
wlLh abdomlnal
paln n/v
MonlLor urlne
ouLpuL




name of Lhe drug lndlcaLlon and
Mechanlsm of AcLlon
ConLralndlcaLlon Slde LffecL nurslng ManagemenL
Gener|c Name
Pyosclnen
buLylbromlde
8rand Name
8uscopan
C|ass|f|cat|on
AnLlspasmodlc
AnLlchollnerglc

acLs by
lnLerferlng wlLh
Lhe Lransmlsslon
of nerve
lmpulses by
aceLylchollne ln
Lhe
parasympaLheLl
c nervous
sysLem

nd|cat|ons
8uscopan
@ableLs are
lndlcaLed for Lhe
rellef of spasm
of Lhe genlLo
urlnary LracL or
gasLro
lnLesLlnal LracL
and for Lhe
sympLomaLlc
rellef of lrrlLable
8owel
Syndrome

8uscopan
@ableLs should
noL be
admlnlsLered
Lo paLlenLs
wlLh
myasLhenla
gravls
megacolon and
narrow angle
glaucoma ln
addlLlon Lhey
should noL be
glven Lo
paLlenLs wlLh a
known
hypersenslLlvlL
y Lo hyosclne
n
buLylbromlde
or any oLher
componenL of
Lhe producL

CNS dlzzlness anaphylacLlc
reacLlons anaphylacLlc shock
lncreased lC dlsorlenLaLlon
resLlessness lrrlLablllLy
dlzzlness drowslness
headache confuslon
halluclnaLlon dellrlum
lmpalred
memory
CV hypoLenslon Lachycardla
palplLaLlons flushlng
G ury mouLh consLlpaLlon
nausea eplgasLrlc dlsLress
DLM flushlng dyshldrosls
GU Drlnary reLenLlon urlnary
heslLancy
esp dyspnea bronchlal
plugglng depressed resplraLlon
LLN1 mydrlasls dllaLed puplls
blurred vlslon phoLopobla
lncreased lnLraocular pressure
dlfflculLy of swallowlng

urug compaLlblllLy should be
monlLored closely ln paLlenLs
requlrlng ad[uncLlve Lherapy
Avold drlvlng operaLlng
machlnery afLer parenLeral
admlnlsLraLlon
Avold sLrlcL heaL
alse slde ralls as a
precauLlon because some
paLlenLs become Lemporarlly
exclLed or dlsorlenLed and
some develop amnesla or
become drowsy
eorlenL paLlenL as needed
@olerance may develop when
Lherapy ls prolonged
ALroplnellke LoxlclLy may
cause dose relaLed adverse
reacLlons lndlvldual
Lolerance varles greaLly
Cverdose may cause curare
llke effecLs such as
resplraLory paralysls keep
emergency equlpmenL
avallable


name of Lhe drug lndlcaLlon and Mechanlsm of
AcLlon
ConLralndlcaLlon Slde LffecL nurslng ManagemenL
Gener|c Name
vlLamln k
8rand Name
Aqua MephyLon vlL
k

O AnLlcoagulanLlnduced
proLhrombln deflclency
caused by coumarln or
lndanedlone derlvaLlves
O rophylaxls and Lherapy of
hemorrhaglc dlsease of
Lhe newborn
O hypoproLhromblnemla
due Lo anLlbacLerlal
Lherapy
O hypoproLhromblnemla
secondary Lo facLors
llmlLlng absorpLlon or
synLhesls of vlLamln k
eg obsLrucLlve [aundlce
blllary flsLula sprue
ulceraLlve colllLls cellac
dlsease lnLesLlnal
resecLlon cysLlc flbrosls of
Lhe pancreas and reglonal
enLerlLls

PypersenslLlvlLy Lo
any componenL of
Lhls medlcaLlon
@ranslenLflushlng
sensaLlons and
pecullar sensaLlons
of LasLe have been
observed as well as
rare lnsLances of
dlzzlness rapld and
weak pulse profuse
sweaLlng brlef
hypoLenslon dyspnea
and cyanosls
aln swelllng and
Lenderness aL Lhe
ln[ecLlon slLe may
occur
@he posslblllLy of
allerglc senslLlvlLy
lncludlng an
anaphylacLold
reacLlon should be
kepL ln mlnd
lnfrequenLly usually
afLer repeaLed
ln[ecLlon
eryLhemaLous
lnduraLed prurlLlc
plaques have
occurred rarely Lhese
have progressed Lo

sclerodermallke
leslons LhaL have
perslsLed for long
perlods ln oLher
cases Lhese leslons
have resembled
eryLhema persLans





name of Lhe drug lndlcaLlon and Mechanlsm
of AcLlon
ConLralndlcaLlon Slde LffecL nurslng ManagemenL
Cenerlc name
@ranexamlc Acld

8rand name
Mlcranex
roduces an
anLlflbrlnolyLlc
effecL by
compeLlLlvely
lnhlblLlng Lhe
acLlvaLlon of
plasmlnogen Lo
plasmln lL ls also a
weak
noncompeLlLlve
lnhlblLor of
plasmln

nd|cat|ons
PeredlLary
angloneuroLlc
edema

lncreased local
flbrlnolysls when
Lhe dlagnosls ls
lndlcaLlve of
hyperflbrlnolysls
aLlenLs wlLh a
hlsLory or rlsk of
Lhrombosls

aLlenLs wlLh
acqulred
dlsLurbances of color
vlslon
ale skln
@roubled breaLhlng wlLh
exerLlon
Dnusual bleedlng or brulslng
Dnusual Llredness or
weakness
ulfflculLy wlLh movlng

lever

llushlng

MonlLor closely ln
dlssemlnaLed lnLravascular
coagulaLlon

Advlse paLlenL Lo reporL slde
effecLs assoclaLed wlLh Lhe
drug

ulsconLlnue lf dlsLurbance ln
colour vlslon occurs




name of Lhe drug lndlcaLlon and Mechanlsm
of AcLlon
ConLralndlcaLlon Slde LffecL nurslng ManagemenL
Gener|c name
ulazepam

C|ass|f|cat|on
8enzodlazeplne
AnxlolyLlc

Dosage
10mg/2ml

nd|cat|ons
4 AnxleLy dlsorders
4 lor Lhe LreaLmenL of
aglLaLlon Lremors
dellrlum selzures and
halluclnaLlons resulLlng
from alcohol
wlLhdrawal
4 @reaLmenL of selzures
and rellef of muscle
spasms ln some
neurologlcal dlseases


4 regnancy
4 nurslng moLhers
4 PypersenslLlvlLy
4 MyasLhenla
gravls
4 reexlsLlng CnS
depresslon or
coma
4 resplraLory
depresslon
4 acuLe pulmonary
lnsufflclency
4 sleep apnoea
syndrome
4 severe hepaLlc
lmpalrmenL
4 acuLe narrow
angle glaucoma
chlldren 6 mLh
(oral)
Most common
4 urowslness
4 laLlgue
4 aLaxla (loss of
balance)
are
Muscle spasm
Confuslon
uepresslon
Speech problems
uouble vlslon

4 Can lead Lo addlcLlon
(dependency) especlally when
hlgher dosages are used over
prolonged perlods of Llme
4 ulazepam ls excreLed ln breasL
mllk and can affecL nurslng
lnfanLs @herefore dlazepam
should noL be used by women
who are nurslng
4 Alcohol or medlcaLlons LhaL
cause sedaLlon may add Lo Lhe
sedaLlve effecLs of dlazepam
aLlenLs Laklng benzodlazeplnes
should avold such comblnaLlons
4 @he followlng drugs may
prolong Lhe effecLs of dlazepam
by lnhlblLlng llver enzymes LhaL
break down dlazepam uosages
may need Lo be decreased when
Lhese drugs are used wlLh
dlazepam
ClmeLldlne (@agameL)
keLoconazole (nlzoral)
Cmeprazole (rllosec
aplnex)
lluvoxamlne (uvox) and
lluoxeLlne (rozac)



name of Lhe drug lndlcaLlon and Mechanlsm
of AcLlon
ConLralndlcaLlon Slde LffecL nurslng ManagemenL
Pydralazlne
(Apresollne)
Pydralazlne

ulrecLly relaxes arLerlolar
smooLh muscle

vasodllalon

owers 8lood ressure

nd|cat|on
reeclampsla /
Lclampsla
ConLralndlcaLed Lo
pLs hypersenslLlve
Lo Lhe drug and any
of lLs componenL
and ln Lhose wlLh
coronary arLery
dlsease or mlLral
valvular rheumaLlc
hearL dlsease

Dse cauLlously ln
paLlenLs wlLh
suspecLed cardlac
dlsease CvA or
severe renal
lmpalrmenL and ln
Lhose Laklng oLher
anLlhyLenslves
CnS perlpheral
neurlLls headache
dlzzlness

Cv orLhosLaLlc
hypoLenslon
Lachycardla
arryLhmlas anglna
palplLaLlons

Cl n/v dlarrhea
anorexla

PemaLologlc
neuLropenla
leukopenla
agranulocyLopenla

MeLabollc welghL
galn sodlum
reLenLlon

Skln rash
Assess blood pressure
before sLarLlng Lherapy and
regularly LhereafLer

lnsLrucL cllenL Lo Lake oral
form wlLh meals

lnform cllenL LhaL
orLhosLaLlc hypoLenslon can
be mlnlmlzed by rlslng
slowly and noL changlng
poslLlon suddenly

@ell pL noL Lo abrupLly
sLop Laklng drug buL Lo call
prescrlber lf adverse
reacLlon occurs

@ell cllenL Lo llmlL sodlum
lnLake