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Interstitial fluid (or tissue fluid) is a solution that bathes and surrounds the cells of multicellular animals. It is the main component of the extracellular fluid, which also includes plasma and transcellular fluid. The interstitial fluid is found in the interstitial spaces, also known as the tissue spaces. On average, a person has about 11 litres (2.4 imperial gallons) of interstitial fluid, providing the cells of the body with nutrients and a means of waste removal.
Contents
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1 Production and removal o 1.1 Formation of tissue fluid o 1.2 Removal of tissue fluid 2 Composition 3 Physiological function 4 See also 5 References 6 External links
[edit] Composition
Interstitial fluid consists of a water solvent containing amino acids, sugars, fatty acids, coenzymes, hormones, neurotransmitters, salts, as well as waste products from the cells. The composition of tissue fluid depends upon the exchanges between the cells in the biological tissue and the blood. This means that tissue fluid has a different composition in different tissues and in different areas of the body. Not all of the contents of the blood pass into the tissue, which means that tissue fluid and blood are not the same. Red blood cells, platelets, and plasma proteins cannot pass through the walls of the capillaries. The resulting mixture that does pass through is, in essence, blood plasma without the plasma proteins. Tissue fluid also contains some types of white blood cell, which help combat infection. Lymph is considered a part of the interstitial fluid. The lymphatic system returns protein and excess interstitial fluid to the circulation.
The ionic composition of the interstitial fluid and blood plasma vary due to the GibbsDonnan effect. This causes a slight difference in the concentration of cations and anions between the two fluid compartments.
[edit] References
Marieb, Elaine N. (2003). Essentials of Human Anatomy & Physiology (Seventh Edition ed.). San Francisco: Benjamin Cummings. ISBN 0-8053-5385-2.
8.690) [show]v d eHistology: connective tissue (TH H2.00.03) [show]v d eUrinary system, physiology: renal physiology and acid-base physiology
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