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AV synchrony
V-V synchrony chronotropy Early 90s Mid 90s Late 90s 2000
AAI VVI RR P
Cumulative survival
0.8 0.6
Atrial pacing
Years
Cumulative Risk
P=0.33
0.2 Ventricular pacing
0.1
Physiologic pacing
0.0 1 2 3 4
Cumulative Risk
P=0.05
0.1
Physiologic pacing
0.0 1 2 3 4
Event rate
24
30
36
42
48
54
60
Months
Event rate
0.30 0.25 0.20 0.15 0.10 0.05 0.00 0 6 12 18 24 30 36 42 48 54 60 Dual chamber pacing P=0.13 Ventricular pacing
Months
MOST: AF
0.40 0.35 Ventricular pacing P=0.008
Event rate
0.30 0.25 0.20 0.15 0.10 0.05 0.00 0 6 12 18 24 30 36 42 48 54 60 Dual chamber pacing
Months
Problems of RV Pacing
Problems of RV Pacing
RV apical pacing frequently caused myocardial perfusion defects and regional wall motion abnormalities.
Problems of RV Pacing
Problems of RV Pacing
LV systolic dysfunction may develop after long-term RV apical pacing. Prolongation of paced QRSd 180 ms suggests development of systolic LVD.
Problems of RV Pacing
80
LVEF-FU (%)
220
240
260
QRSd (ms)
DDDR>40%
20
VVI unpaced
10
DDDR40%
0 0
3 month FU to primary end-point
12
18
LV-EF <0.35
AAI