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Course Specification
Course Code: Course Title: Academic Year/Level:
PHR 563
Specialization:
Virology
No. of Instructional Units:
2 Crs
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Course Specification
2-Course Aim
a. Recognize structural components of the viruses and how they influence pathogenesis of the disease and how they are transmitted among individuals and populations b. Develop the ability to correlate the clinical picture with laboratory information to establish a diagnosis. c. Students will be able to become abreast or emerging viral diseases and the challenges they pose that assist the pharmaceutical industry.... a1-Identify and describe the members of the viral world Tabulate the differences between bacteria and viruses a2-Identify, describe, name and label viral structure Describe and explain replication of viruses a3-Identify and distinguish viruses causing diseases Identify and interpret the signs and symptoms of some viral diseases. b1-Construct and apply the laboratory diagnosis, mechanism of infection, disease transmission and treatment of some viral diseases b2- Discover and report the different laboratory results and relate them with the clinical picture to be able to establish a diagnosis. c1- Distinguish the viral infections c2- Analysis by PCR c3- Perform serology c4- Preparation of viral vaccines
3-Intended Learning Outcome: By the end of this course , student will be able to:
b- Intellectual Skills
c- Professional Skills
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Course Specification
d- General Skills
d1-Verify the different characteristics and morphology of viruses causing infection depending on their morphology d2-Propose ways in order to prevent and guard against different infections by viruses. Sketch microscopic appearance of viruses d3-Practice the ability to communicate with others and work within a group d4-Practice the ability to prepare certain topics of the course and be able to extract information from text, reference books and the internet d5- Practice the ability to develop the good performance for oral presentations..... General features of viruses. Viral replications. Classification of viruses Bacteriophage. Antiviral chemotherapy. Viral vaccines. Interferon. Laboratory diagnosis of viral infections. I-DNA viruses: Herpes viruses. Papillomaviruses. Adenoviruses. II-Hepatitis viruses. Ill-RNA viruses: Picornaviruses. Orthomyxoviruses. Paramyxoviruses. Rhabdoviruses. Retroviruses (HI V/AIDS)....
Dr. Mervat Elsaygh- Pharos University
4-Course Content
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Course Specification
5-Teaching and Learning Methods
Lectures Demonstration of more detailed information by Power point projection . -Tutorial -Group presentation -Self learning assignments -Quizzes
None
7-Student Assessment:
a-Procedures used: b-Schedule:
Written exam Assignments Quizzes Quizzes: weeks 6 and 12 and Assignemnts: week 7 final exam: weeks 16 and 1 7 Course Work Final exam 50 % 50%
5
c-Weighing of Assessment:
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Course Specification
8-List of References:
a-Course Notes
b- Required Books - GJ Tortora, BR Funke, CL Case, 2010, Microbiology, an (Textbooks) introduction. Ninth edition by. Pearson Education, Inc.
- RA Harvey, PL Champe, BD Fisher L, 2007, Lippincot's Illustrated Reviews: Microbiology. 2nd Edition by. Lippincott's Williams and Wilkins
c-Recommended Books d- Periodicals, Web Sites, ..., etc.
IS ButeL SA Morse, 2004, Medical Microbiology. Twentythird edition by .IF Brooks LANGE Medical Books. www.virology.net www.elsevier.com/locate/yviro
Course Instructor: Prof. Dr. Mervat Elsaygh Dr. Rania AboZahra Head of Department: Prof.Dr. Hoda Elshamy
Dr. Mervat Elsaygh- Pharos University
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OUTLINE
Definition of the viruses Classification and types Structure and shape Mode of transmission and replication Diseases caused by the viruses Gallery
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2- It carries the viral attachment proteins (VAP) which are glycoproteinsthat attach the virus to a specific receptor on the target cell. 3- Determine the antigenic characters of the virus. 4- It is responsible for the symmetry of the virus.
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VIRAL SYMMETRY
1.
e.g.
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VIRAL SYMMETRY
2Helical symmetry: the capsomeresare bound together as ribbons which are twisted into spiral. The NA winds in a helical form inside the protein helix e.g. Influenza virus.
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ENVELOPE
It is a protein containing a lipid membrane that surrounds the capsidin some viruses. Here the VAP is carried and present on the envelope. The enveloped viruses are killed by lipid solvents e.g. ether
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CLASSIFICATION OF VIRUSES
DNA Viruses
Most are double stranded All are icosahedralexcept small pox virus. Most are none enveloped except Herpesv and hepatitis B virus.
RNA Viruses
Most are Helical and all the helical are enveloped. Some are enveloped icosahedralas the HIVand the German measles v, while Polio and hepatitis C are naked
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Classification By Symptomatology
1- Diseases of the respiratory tract: influenza, parainfluenzaand common cold. 2- Diseases of the nervous system: poliomyelitis, aseptic meningitis and rabies. 3- Localized disease of the skin or mucous membrane: Herpes simplex type 1 (oral) and type 2 (genital) and wart.
Dr. Mervat Elsaygh- Pharos University
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Classification By Symptomatology
4- Diseases of the liver: Hepatitis A E 5- Diseases of the eye: Herpesconjunctivitis 6- Diseases of the GIT: rotavirus diarrhea, enteric adenoviruses 7- Diseases of the genital tract: HSV 2, HIV
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Viruses Replication
Viruses are obligatory intracellular as they are metabolically inert. After invading a cell, viruses use their own genes to redirect the machinery of the cell to produce new viruses; this is done by virus messenger RNA.
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Assembly
It is combination of the viral nucleic acid with the protein coat
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Release
Either by lysisof the cell in the none enveloped viruses or by budding from the cell membrane where the envelope is acquired from this membrane
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Interferon
Are proteins produced by human cells in response to viral infection.
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Properties
1. 2. 3. 4. 5.
Are the first line of body defense against viral infection. It inhibit sviral replication. Host species specific. Not viral specific. It acts also as cell immune regulatory activity as activation of natural killer cells, activation of monocytesand macrophages and inhibition of cell growth. Recombinant DNA techniques now allow production of inexpensive large amount of interferon by yeast and bacteria.
Dr. Mervat Elsaygh- Pharos University
6.
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CLINICAL USES
Used in treatment of sever viral infection e.g. rabies, herpetic encephalitis,.etc In the treatment of persistent viral infections e.g. hepatitis B & C,etc Used as anticancer agent on the basis of their cell immunomodulation properties. Treatment of multiple sclerosis.
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Gallery
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Gallery
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Gallery
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Homework Questions
Define:
Interferon, Its Clinical uses, & its properties
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Thank You