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Author: Yvonne Cheng, MD, MPH; Chief Editor: David Chelmow, MD more... Updated: Feb 10, 2011
Definition
Labor is a physiologic process during which the products of conception (ie, the fetus, membranes, umbilical cord, and placenta) are expelled outside of the uterus. Labor is achieved with changes in the biochemical connective tissue and with gradual effacement and dilatation of the uterine cervix as a result of rhythmic uterine contractions of sufficient frequency, intensity, and duration.[1, 2] Labor is a clinical diagnosis. The onset of labor is defined as regular, painful uterine contractions resulting in progressive cervical effacement and dilatation. Cervical dilatation in the absence of uterine contraction suggests cervical insufficiency, whereas uterine contraction without cervical change does not meet the definition of labor.
clamping/cutting, and controlled cord traction of the umbilical cord. A systematic review of the literature that included 5 randomized controlled trials comparing active and expectant management of the third stage reports that active management shortens the duration of the third stage and is superior to expectant management with respect to blood loss/risk of postpartum hemorrhage; however, active management is associated with an increased risk of unpleasant side effects.[16] The third stage of labor is considered prolonged after 30 minutes, and active intervention, such as manual extraction of the placenta, is commonly considered.[2]
Epidemiology
As the childbearing population in the United States has changed, the clinical obstetric management of labor also has evolved since Friedman's studies. Data from number a studies have suggested that normal labor can progress at a rate much slower than that Friedman and Sachtleben[4, 5] had described. Zhang et al examined the labor progression of 1,162 nulliparas who presented in spontaneous labor and constructed a labor curve that was markedly different from Friedman's: The average interval to progress from 4-10 cm of cervical dilatation was 5.5 hours compared with 2.5 hours of Friedman's labor curve.[17] Kilpatrick et al[6] and Albers et al[7] also reported that the median lengths of first and second stages of labor were longer than those Friedman suggested. A number of investigators have identified several maternal characteristics obstetric factors that are associated with the length of labor. One group reported that increasing maternal age was associated with a prolonged second stage but not first stage of labor.[18] While nulliparity is associated with a longer labor compared to multiparas, increasing parity does not further shorten the duration of labor.[19] Some authors have observed that the length of labor differs among racial/ethnic groups. One group reported that Asian women have the longest first and second stages of labor compared with Caucasian or African American women[20] , and American Indian women had second stages shorter than those of non-Hispanic Caucasian women.[7] However, others report conflicting findings.[21, 22] Differences in the results may have been due to variations in study designs, study populations, labor management, or statistical power. In one large retrospective study of the length of labor, specifically with respect to race and/or ethnicity, the authors observed no significant differences in the length of the first stage of labor among different racial/ethnic groups. However, the second stage was shorter in African American women than in Caucasian women for both nulliparas (-22 min) and multiparas (-7.5 min). Hispanic nulliparas, compared with their Caucasian counterparts, also had a shortened second stage, whereas no differences were seen for multiparas. In contrast, Asian nulliparas had a significantly prolonged second stage compared with their Caucasian counterparts, and no differences were seen for multiparas.[23]
Mechanism of Labor
The ability of the fetus to successfully negotiate the pelvis during labor involves changes in position of its head during its passage in labor. The mechanisms of labor, also known as the cardinal movements, are described in relation to a vertex presentation, as is the case in 95% of all pregnancies. Although labor and delivery occurs in a continuous fashion, the cardinal movements are described as 7 discrete sequences, as discussed below.[2]
Engagement
The widest diameter of the presenting part (with a well-flexed head, where the largest transverse diameter of the fetal occiput is the biparietal diameter) enters the maternal pelvis to a level below the plane of the pelvic inlet. On the pelvic examination, the presenting part is at 0 station, or at the level of the maternal ischial spines.
Descent
The downward passage of the presenting part through the pelvis. This occurs intermittently with contractions. The rate is greatest during the second stage of labor.
Flexion
As the fetal vertex descents, it encounters resistance from the bony pelvis or the soft tissues of the pelvic floor, resulting in passive flexion of the fetal occiput. The chin is brought into contact with the fetal thorax, and the presenting diameter changes from occipitofrontal (11.0 cm) to suboccipitobregmatic (9.5 cm) for optimal passage through the pelvis.
Internal rotation
As the head descends, the presenting part, usually in the transverse position, is rotated about 45 to anteroposterior (AP) position under the symphysis. Internal rotation brings the AP diameter of the head in line with the AP diameter of the pelvic outlet.
Extension
With further descent and full flexion of the head, the base of the occiput comes in contact with the inferior margin of the pubic symphysis. Upward resistance from the pelvic floor and the downward forces from the uterine contractions cause the occiput to extend and rotate around the symphysis. This is followed by the delivery of the fetus' head.
Expulsion
After the fetus' head is delivered, further descent brings the anterior shoulder to the level of the pubic symphysis. The anterior shoulder is then rotated under the symphysis, followed by the posterior shoulder and the rest of the fetus.
Physical examination
Physical examination should include documentation of the patient's vital signs, the fetus' presentation, and assessment of the fetal well-being. The frequency, duration, and intensity of uterine contractions should be assessed, particularly the abdominal and pelvic examinations in patients who present in possible labor. Abdominal examination begins with the Leopold maneuvers described below[2] : The initial maneuver involves the examiner placing both of his or her hands on each upper quadrant of the patient's abdomen and gently palpating the fundus with the tips of the fingers to define which fetal pole is present in the fundus. If it is the fetus' head, it should feel hard and round. In a breech presentation, a large, nodular body is felt. The second maneuver involves palpation in the paraumbilical regions with both hands by applying gentle but deep pressure. The purpose is to differentiate the fetal spine (a hard, resistant structure) from its limbs (irregular, mobile small parts) to determinate the fetus' position. The third maneuver is suprapubic palpation by using the thumb and fingers of the dominant hand. As with the first maneuver, the examiner ascertains the fetus' presentation and estimates its station. If the presenting part is not engaged, a movable body (usually the fetal occiput) can be felt. This maneuver also allows for an assessment of the fetal weight and of the volume of amniotic fluid. The fourth maneuver involves palpation of bilateral lower quadrants with the aim of determining if the presenting part of the fetus is engaged in the mother's pelvis. The examiner stands facing the mother's feet. With the tips of the first 3 fingers of both hands, the examiner exerts deep pressure in the direction of the axis of the pelvic inlet. In a cephalic presentation, the fetus' head is considered engaged if the examiner's hands diverge as they trace the fetus' head into the pelvis. Pelvic examination is often performed using sterile gloves to decrease the risk of infection. If membrane rupture is suspected, examination with a sterile speculum is performed to visually confirm pooling of amniotic fluid in the posterior fornix. The examiner also looks for fern on a dried sample of the vaginal fluid under a microscope and checks the pH of the fluid by using a nitrazine stick or litmus paper, which turns blue if the amniotic fluid is alkalotic. If frank bleeding is present, pelvic examination should be deferred until placenta previa is excluded with ultrasonography. Furthermore, the pattern of contraction and the patient's presenting history may provide clues about placental abruption.
Digital examination of the vagina allows the clinician to determine the following: (1) the degree of cervical dilatation, which ranges from 0 cm (closed or fingertip) to 10 cm (complete or fully dilated), (2) the effacement (assessment of the cervical length, which is can be reported as a percentage of the normal 3- to 4-cm-long cervix or described as the actual cervical length); actual reporting of cervical length may decrease potential ambiguity in percent-effacement reporting, (3) the position, ie, anterior or posterior, and (4) the consistency, ie, soft or firm. Palpation of the presenting part of the fetus allows the examiner to establish its station, by quantifying the distance of the body (-5 to +5 cm) that is presenting relative to the maternal ischial spines, where 0 station is in line with the plane of the maternal ischial spines).[2] The pelvis can also be assessed either by clinical examination (clinical pelvimetry) or radiographically (CT or MRI). The pelvic planes include the following: Pelvic inlet: The obstetrical conjugate is the distance between the sacral promontory and the inner pubic arch; it should measure 11.5 cm or more. The diagonal conjugate is the distance from the undersurface of the pubic arch to sacral promontory; it is 2 cm longer than the obstetrical conjugate. The transverse diameter of the pelvic inlet measures 13.5 cm. Midpelvis: The midpelvis is the distance between the bony points of ischial spines, and it typically exceeds 12 cm. Pelvic outlet: The pelvic outlet is the distance between the ischial tuberosities and the pubic arch. It usually exceeds 10 cm. The shape of the mother's pelvis can also be assessed and classified into 4 broad categories based on the descriptions of Caldwell and Moloy: gynecoid, anthropoid, android, and platypelloid.[24] Although the gynecoid and anthropoid pelvic shapes are thought to be most favorable for vaginal delivery, many women can be classified into 1 or more pelvic types, and such distinctions can be arbitrary.[2]
Workup
High-risk pregnancies can account for up to 80% of all perinatal morbidity and mortality. The remaining perinatal complications arise in pregnancies without identifiable risk factors for adverse outcomes.[25] Therefore, all pregnancies require a thorough evaluation of risks and close surveillance. As soon as the mother arrives at the Labor and Delivery suite, external tocometric monitoring for the onset and duration of uterine contractions and use of a Doppler device to detect fetal heart tones and rate should be started. In the presence of labor progression, monitoring of uterine contractions by external tocodynamometry is often adequate. However, if a laboring mother is confirmed to have rupture of the membranes and if the intensity/duration of the contractions cannot be adequately assessed, an intrauterine pressure catheter can be inserted into the uterine cavity past the fetus to determine the onset, duration, and intensity of the contractions. Because the external tocometer records only the timing of contractions, an intrauterine pressure catheter can be used to measure the intrauterine pressure generated during uterine contractions if their strength is a concern. While it is considered safe, placental abruption has been reported as a rare complication of an intrauterine pressure catheter placed extramembraneously.[26] Often, fetal monitoring is achieved using cardiotography, or electronic fetal monitoring. Cardiotography as a form of fetal assessment in labor was reviewed using randomized and quasirandomized controlled trials involving a comparison of continuous cardiotocography with no monitoring, intermittent auscultation, or intermittent cardiotocography. This review concluded that continuous cardiotocography during labor is associated with a reduction in neonatal seizures but not cerebral palsy or infant mortality; however, continuous monitoring is associated with increased cesarean and operative vaginal deliveries.[27] If nonreassuring fetal heart rate tracings by cardiotography (eg, late decelerations) are noted, a fetal scalp electrode may be applied to generate sensitive readings of beat-to-beat variability. However, a fetal scalp electrode should be avoided if the mother has HIV, hepatitis B or hepatitis C infections, or if fetal thrombocytopenia is suspected. Recently, a framework has been suggested to classify and standardize the interpretation of a fetal heart rate monitoring pattern according to the risk of fetal acidemia with the intention of minimizing neonatal acidemia without excessive obstetric intervention.[28] The question of whether fetal pulse oximetry may be useful for fetal surveillance in labor was examined in a review of 5 published trials comparing fetal pulse oximetry and cardiotography with cardiotography alone. It concluded that existing data provide limited support for the use of fetal pulse oximetry when used in the presence of a nonreassuring fetal heart rate tracing to reduce caesarean delivery for nonreassuring fetal status. The addition of fetal pulse oximetry does not reduce overall caesarean deliveries.[29] Further evaluation of a fetus at risk for labor intolerance or distress can be accomplished with blood sampling from fetal scalp capillaries. This procedure allows for a direct assessment of fetal oxygenation and blood pH. A pH of < 7.20 warrants further investigation for the fetus' well-being and for possible resuscitation or surgical intervention. Routine laboratory studies of the parturient, such as CBC analysis, blood typing and screening, and urinalysis, are usually performed. Intravenous (IV) access is established.
treatment).[46, 47] While the ACOG defines labor dystocia as abnormal labor that results form abnormalities of the power (uterine contractions or maternal expulsive forces), the passenger (position, size, or presentation of the fetus), or the passage (pelvis or soft tissues), labor dystocia can rarely be diagnosed with certainty.[1] Often, a "failure to progress" in the first stage is diagnosed if uterine contraction pattern exceeds 200 Montevideo units for 2 hours without cervical change during the active phase of labor is encountered.[1] Thus, the traditional criteria to diagnose active-phase arrest are cervical dilatation of at least 4 cm, cervical changes of < 1 cm in 2 hours, and a uterine contraction pattern of >200 Montevideo units. These findings are also a common indication for cesarean delivery. Proceeding to cesarean delivery in this setting, or the "2-hour rule," was challenged in a clinical trial of 542 women with active phase arrest.[48] In this cohort of women diagnosed with active phase arrest, oxytocin was started, and cesarean delivery was not performed for labor arrest until adequate uterine contraction lasted at least 4 hours (>200 Montevideo units) or until oxytocin augmentation was given for 6 hours if this contraction pattern could not be achieved. This protocol achieved vaginal delivery rates of 56-61% in nulliparas and 88% in multiparas without severe adverse maternal or neonatal outcomes. Therefore, extending the criteria for active-phase labor arrest from 2 to at least 4 hours appears to be effective in achieving vaginal birth.[48, 1]
mother's abdomen.
Third stage of labor - Delivery of the placenta and the fetal membranes
The labor process has now entered the third stage, ie, delivery of the placenta. Three classic signs indicate that the placenta has separated from the uterus: (1) The uterus contracts and rises, (2) the cord suddenly lengthens, and (3) a gush of blood occurs.[2] Delivery of the placenta usually happens within 5-10 minutes after delivery of the fetus, but it is considered normal up to 30 minutes after delivery of the fetus. Excessive traction should not be applied to the cord to avoid inverting the uterus, which can cause severe postpartum hemorrhage and is an obstetric emergency. The placenta can also be manually separated by passing a hand between the placenta and uterine wall. After the placenta is delivered, inspect it for completeness and for the presence of 1 umbilical vein and 2 umbilical arteries. Oxytocin can be administered throughout the third stage to facilitate placental separation by inducing uterine contractions and to decrease bleeding. Expectant management of the third stage involves allowing the placenta to deliver spontaneously, whereas active management involves administration of uterotonic agent (usually oxytocin, an ergot alkaloid, or prostaglandins) before the placenta is delivered. This is done with early clamping and cutting of the cord and with controlled traction on the cord while placental separation and delivery are awaited. A review of 5 randomized trials comparing active versus expectant management of the third stage demonstrated that active management was associated with lowered risks of maternal blood loss, postpartum hemorrhage, and prolongation of the third stage, but it increased maternal nausea, vomiting, and blood pressure (when ergometrine was used). However, given the reduced risk of complications, this review recommends that active management is superior to expectant management and should be the routine management of choice.[16] A multicenter, randomized, controlled trial of the efficacy of misoprostol (prostaglandin E1 analog) compared with oxytocin showed that oxytocin 10 IU IV or given intramuscularly (IM) was preferable to oral misoprostol 600 mcg for active management of the third stage of labor in hospital settings.[55] Therefore, if the risks and benefits are balanced, active management with oxytocin may be considered a part of routine management of the third stage. After the placenta is delivered, the labor and delivery period is complete. Palpate the patient's abdomen to confirm reduction in the size of the uterus and its firmness. Ongoing blood loss and a boggy uterus suggest uterine atony. A thorough examination of the birth canal, including the cervix and the vagina, the perineum, and the distal rectum, is warranted, and repair of episiotomy or perineal/vaginal lacerations should be carried out. Franchi et al found that topically applied lidocaine-prilocaine (EMLA) cream was an effective and satisfactory alternative to mepivacaine infiltration for pain relief during perineal repair. In a randomized trial of 61 women with either an episiotomy or a perineal laceration after vaginal delivery, women in the EMLA group had lower pain scores than those in the mepivacaine group (1.7 +/- 2.4 vs 3.9 +/- 2.4; P = .0002), and a significantly higher proportion of women expressed satisfaction with anesthesia method in the EMLA group than in the mepivacaine group (83.8% vs 53.3%; P = .01).[56]
Pain Control
Laboring women often experience intense pain. Uterine contractions result in visceral pain, which is innervated by T10-L1. While in descent, the fetus' head exerts pressure on the mother's pelvic floor, vagina, and perineum, causing somatic pain transmitted by the pudendal nerve (innervated by S2-4).[57] Therefore, optimal pain control during labor should relieve both sources of pain. A number of opioid agonists and opioid agonist-antagonists can be given in intermittent doses for systemic pain control. These include meperidine 25-50 mg IV every 1-2 hours or 50-100 mg IM every 2-4 hours, fentanyl 50-100 mcg IV every hour, nalbuphine 10 mg IV or IM every 3 hours, butorphanol 1-2 mg IV or IM every 4 hours, and morphine 2-5 mg IV or 10 mg IM every 4 hours.[57] As an alternative, regional anesthesia may be given. Options are epidural, spinal, or combined spinal epidural anesthesia. These provide partial to complete blockage of pain sensation below T8-10, with various degree of motor blockade. These blocks can be used during labor and for surgical deliveries. Studies performed to compare the analgesic effect of regional anesthesia and parenteral agents showed that regional anesthesia provides superior pain relief.[58, 36, 59] Although some researchers reported that epidural anesthesia is associated with a slight increase in the duration of labor and in the rate of operative vaginal delivery,[60, 61] large randomized controlled studies did not reveal a difference in frequency of cesarean delivery between women who received parenteral analgesics compared with women who received epidural anesthesia[58, 59, 61] given during early-stage or later in labor.[62] Although regional anesthesia is effective as a method of pain control, common adverse effects include maternal hypotension, maternal temperature >100.4F, postdural puncture headache, transient fetal heart deceleration, and pruritus (with added opioids).[57] Despite the many methods available for analgesia and anesthesia to manage labor pain, some women may not wish to use conventional pain medications during labor, opting instead for a natural childbirth. Although these women may use breathing and mental exercises to help alleviate labor pain, they should be assured that pain relief can be administered at any time during labor.
Of note, use of nonsteroidal anti-inflammatory drugs (NSAIDs) are relatively contraindicated in the third trimester of pregnancy. The repeated use of NSAIDs has been associated with early closure of the fetal ductus arteriosus in utero and with decreasing fetal renal function leading to oligohydramnios.
References
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