CELLULAR AND MOLECULAR PHARMACOLOGY BIOLOGY 4480/6480 - FALL 2008 DATE August 25 Aug 27 August 29 September 1 September 3 September

5 September 8 September 10 September 12 September 15 September 17 September 19 September 22 September 24 September 26 September 29 October 1 October 3 October 6 October 8 October 10 October 11-14 October 15 October 17 October 20 October 22 October 24 October 27 October 29 October 31 November 3 November 5 November 7 November 10 November 12 November 14 November 17 November 19 November 21 November 24 November 26 November 27-30 December 1 December 3 December 4 December 5 DAY M W F M W F M W F M W F M W F M W F M W F SatTu W F M W F M W F M W F M W F M W F M W M W Th F TOPIC NOTES PAGES Introduction/ Terminology 1-3 Pharmacodynamics 4-7 Pharmacodynamics 4-7 LABOR DAY NO CLASSES Pharmacokinetics 8-12 Pharmacokinetics 8-12 Mechanisms of Drug Interactions 13-15 Mechanisms of Drug Interactions 13-15 Autonomic Principles 16-19 Autonomic Principles 16-19 Cholinergic Drugs 20-24 Cholinergic Drugs/Review for Exam Exam 1 - through Autonomic Principles Cholinergic Drugs 20-24 Adrenergic Drugs 25-28 Adrenergic Drugs 25-28 CNS DRUGS 29-30 Pain and Pain Relief 31-35 CNS depressants 36-37 CNS Stimulants 38-39 Parkinsons Disease 40-42 Psychiatric Disorders 43-48 FALL BREAK NO CLASSES Exam 2 Cholinergic Drugs through Parkinsons Psychiatric Disorders and Treatment 43-48 CARDIOVASCULAR AND RENAL PHYSIOLOGY Overview of Renal and Cardiac Physiology 49-52 Diuretics 53-55 Heart Failure 56-58 Cardiac Arrhythmias 59-60 Hypertension 61-63 Hypertension 61-63 Anticoagulants 64-65 Anticoagulants 64-65 Exam 3 Psychiatric Drugs - Anticoagulants ENDOCRINE PHARMACOLOGY Reproductive Hormones/Infertility /Anabolic Steroids 66-69 Diabetes/Treatment 70-73 Diabetes/Treatment 70-73 Introduction to Chemotherapy 75 Bacterial Infections/Antibiotics 75-76 HIV/therapies 77-78 Cancer/Treatment 79-81 Cancer/Treatment 79-81 THANKSGIVING HOLIDAY New Frontiers New Frontiers Last Day of Classes TBA Study Day Final Exam 8-10 am LS207

FACULTY

Judith A. Cole, Ph.D. Course Director Life Sciences 409A 901.678.1363 jcole2@memphis.edu Your e-text (lecture notes) and slides are posted on UMDrive along with the MATERIAL syllabus. Exam keys for BIOL 4480 ONLY will be posted on UMDrive after each exam.

COURSE

TEXT There is no required text for this class. If you would like a reference text, I recommend Modern Pharmacology with Clinical Applications, 6th Edition by Craig and Stitzel, Lippincott, Williams and Wilkin, publishers. EXAMS BIOL 4480: total of 220 points 3 hourly exams with 40 multiple choice questions (40 points/exam). Make-ups will consist of 10 short answer questions. Final exam - 100 questions/100 points; 40 questions on the last lecture material and 60 on material from exams 1-3. BIOL 6480: total of 220 points 3 hourly exams - 7-10 short answer questions (40 points/exam). Final exam - 100 points; 40 points will cover the last lecture material and 60 points on material from exams 1-3. Make-ups have the same format as in class exams MAKE UP EXAMS MUST BE TAKEN WITHIN TWO WEEKS OF THE EXAMS SCHEDULED DATE. It is your responsibility to arrange your outside schedules (work as well as social) so that they do not conflict with the final exam. Make-ups for the final exam are not available except under extraordinary situations and totally at the discretion of the course director. GRADING: Grades in this course are determined solely by the number of points accumulated on exams as described below. Extra credit work to improve grades is not available and will not be accepted. The following point distributions will guarantee a specific grade, they do not preclude a curve. A 89.5 % of 220 points or 197 points B= 79.5-89.4% of 220 points or 175-196 points C= 69.5-79.4% of 220 points or 153-174 points D= 59.5-69.4% of 220 points or 131-152 points I - incompletes will be issued only if completed work is of passing quality University of Memphis policy on incompletes: The grade of "I" (Incomplete) may be assigned by the faculty member in any course in which the student is unable to complete the work due to extraordinary events beyond the students control that are acceptable to the faculty member. The I may not be used to extend the term for students who complete the course with an unsatisfactory grade. Unless the student completes the requirements for removal of "I" within 45 days from the end of the semester or summer term in which it was received (see University Calendar), the "I" will be changed to "F," whether or not the student is enrolled. The faculty member may grant up to a 45-day extension if sufficient extenuating circumstances exist. At the end of the extension period, the I will automatically revert to F if the student has not completed the requirements. The student will be certified for graduation only when all requirements are met, including the removal of I grades. For students who have an I in a course required to fulfill degree requirements in the semester in which they expect to graduate, the certification process and graduation will automatically be deferred to the next term. Students with Disabilities: The University of Memphis is committed to providing equal opportunity and challenge to all academically qualified students with disabilities and is compliant with Section 504 of the Rehabilitation Act and the Americans with Disabilities Act. If you need accommodation please see me. If you have not registered with Student Disability Services, you must do so. SDS is located in 110 Wilder Tower and their web address is: http://saweb.memphis.edu/sds/