VITA Michael Masterman-Smith, Ph.D. (August 2011) I. Biographical Information: Address: Phone Number: E-mail: II.

Statement of Purpose: My initial background in psychology led me to health-related quality-of-life outcomes research on brain tumor survivors. From there I became intrigued by the disease and this led to my work investigating whether cancer stem (or tumor-initiating) cells were a neurodevelopmental phenomenon. The subsequent isolation of these cells from human pediatric brain tumors served as a fundamental breakthrough in tissue-derived cancer stem cell studies in solid tumors and the methods are now routinely used worldwide for culturing cancer stem cells from a number of human tissues including breast cancer, cervical cancer and melanoma. My doctoral work in the UCLA Department of Molecular and Medical Pharmacology was funded by the Adelson Medidal Research Foundation and a multi-million dollar grant from the National Cancer Institute as part of the founding of the NanoSystems Biology Cancer Center, where I applied my neuropharmacology and cell/molecular biology expertise to multidisciplinary projects involving systems engineering, biotechnology development, physics, materials science and systems biology. I have led teams to successfully complete complex clinically relevant multi-disciplinary academic-industrial bioengineering projects, resulting in multiple patent applications and the co-founding of 2 biotechnology companies. III. Education: Fellow, 2011-Present, California NanoSystems Institute/UCLA Dept. of Psychiatry Geffen UCLA School of Medicine, Westwood, CA Doctor of Philosophy, 10/10, UCLA Dept. of Molecular and Medical Pharmacology Geffen UCLA School of Medicine, Westwood, CA Premedical and mathematics coursework, 10/99 09/01 UCLA, Westwood, CA Master of Arts in Clinical Psychology, 10/98 Pepperdine University Graduate School of Education and Psychology, Culver City, CA Post-baccalaureate coursework, 9/94 5/96 Rutgers University, New Brunswick, NJ
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106 Rees Street, Playa Del Rey, CA 90293 310.467.5708 masterman@gmail.com

Bachelor of Science in Psychology, Minor in Communication, 4/94 Florida State University, Tallahassee, FL IV. Publications: Sun J *, Masterman-Smith M *, Graham N*, Jiao J * . . . Phelps M., van Dam M., Liau L, Mischel PS, Kornblum, HI, Wu H., Lazareff JA, Yong WH, Graeber T, Tseng, HR. A microfluidic platform for systems pathology: Multiparameter single-cell signaling measurements of clinical brain tumor specimens. Cancer Res. 2010 Aug 1. Wang MW, Lin WY, Liu K, Masterman-Smith M, Shen CK. Microfluidics for Positron Emission Tomography (PET) Imaging Probe Development. Molecular Imaging, 2010 Aug;9(4):175-91. Panosyan EH, Laks DR, Masterman-Smith M, Mottahedeh J, Yong, WH, Cloughesy TF, Lazareff, JA, Mischel PS, Moore TB, Kornblum HI. Clinical Outcome in Pediatric Glial and Embryonal Brain Tumors Correlates with In Vitro Multi-passageable Neurosphere Formation. Pediatr Blood Cancer. 2010 Jun 29. Sercarz JA, Bublik M, Joo J, Paiva PB, Areco KN, Brandalise MH, Loh C, Masterman-Smith M, Paiva MB. Outcomes of laser thermal therapy for recurrent head and neck cancer. Otolaryngol Head Neck Surg 2010 Mar;142(3):344-350. Laks DR*, Masterman-Smith M*, Visnyei K., Angenieux B, Liau L., Lazareff JA, Mischel PS, Cloughesy T, Horvath S, Kornblum HI Neurosphere formation is an independent predictor of clinical outcome in malignant glioma. Stem Cells 2009; 27:980987. Nakano I, Masterman-Smith M, Saigusa K, Paucar A, Horvath S, Shoemaker L, Watanabe M, Negro A, Bajpal R., Howes A, Lelievre V, Waschek JA, Lazareff JA, Freije WA, Liau LM, Gilbertson RJ, Cloughesy TF, Geschwind DH, Nelson SF, Mischel PS, Terskikh AV, Kornblum HI. Maternal embryonic leucine zipper kinase is a key regulator of the proliferation of malignant brain tumors, including brain tumor stem cells. Journal of Neuroscience Research 2008 86:48-60. Bublik M, Sercarz JA, Lufkin RB, Masterman-Smith M, Polyakov M, Paiva PB, Blackwell KE, Castro DJ, Paiva MB. Ultrasound-guided laser-induced thermal therapy of malignant cervical adenopathy. Laryngoscope. 2006 Aug;116(8):1507-11.

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Hemmati H, Nakano I, Lazareff JA, Masterman-Smith M, Geschwind DJ, Bronner-Fraser M, Kornblum HI Cancerous stem cells can arise from pediatric brain tumors. Proc Nat Aca Sci 2003 Dec; 100(25): 15178-15183. Virella AA, Galarza M, Masterman-Smith M, Lemus R, Lazareff JA. Distal slit valve and clinically relevant CSF overdrainage in children with hydrocephalus. Childs Nerv Syst 2002 Feb;18(1):15-8. AT&T Bell Laboratories. (1993, August). Customer Trouble Reporting System: User survey results on organizational structure and subjective satisfaction ratings (User Interface Planning and Development Division 51134). Somerset, NJ: Masterman-Smith M, Crossner MS, & Troncone CL. *Authors contributed equally V. Abstracts and Presentations: Masterman-Smith M, Graham N, Sun J, Jiao J, Laks D, Visnyei K, Mottahedeh J, Kamei K, Graeber T, Mischel P, Liau L, Lazareff J, Tseng H, Kornblum H. Development and utilization of Microfluidic Image Cytometry (MIC) technology, a platform for single cell molecular analysis and diagnosis of brain tumors and brain tumor stem cells. UCLA Stem Cell Research Conference, February 12, 2010. Panosyan EH, Laks DR, Masterman-Smith M, Mottahedeh J, Yong WH, Lazareff JA, Mischel P, Moore TB, Kornblum HI. Clinical outcome in pediatric glial and embryonal brain tumors correlates with in vitro renewable neurosphere formation. Selected for presentation. American Society of Pediatric Hematology Oncology, Montreal, Quebec, Canada, April 7-10, 2010. Graham N, Sun J, Masterman-Smith M, Jiao J, . . . Phelps M, van Dam M, Liau L, Mischel P, Kornblum H, Wu H, Lazareff J, Yong W, Graeber T, Tseng H. A microfluidic platform for systems analysis of signaling and metabolism: single-cell measurements of clinical brain tumor specimens. American Association of Cancer Research Special Conference: Cancer and Metabolism, San Diego, CA, September 13-16, 2009. Masterman-Smith M, Orozco N, Sun J, Visnyei K, Mottahedeh J, Kamei K., Ohashi M, Graeber T, Mischel P, Liau L, Lazareff J, Tseng H, Kornblum H. Utilization of Microfluidic Image Cytometry (MIC) technology for molecular analysis of brain tumor stem cells. Annual Meeting of the Society for Neuroscience, Washington, DC, November 16-19, 2008.

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Sun J, Ohashi M, Kamei K, Wang H, Lu Y, Masterman-Smith M, Yu Z., Nathanson, D, Lazareff J, Liau L, Kornblum H., Mischel P, Tseng H. Microfluidic Image Cytometry(MIC) Technology for In Vitro Molecular Diagnostics. Investigators Annual Meeting, National Cancer Institutes Nanotechnology Alliance for Cancer, Chicago, IL, September 8-10, 2008. Sun J, Ohashi M, Kamei K., Wang H, Masterman-Smith M. Yu Z., Suh C, Kornblum H, Nathanson D, Huang T, Mischel P, Tseng H. Microfluidic Imaging Cytometry (MIC) technology for in vitro molecular diagnostics. Internationational. Conference on Miniaturized Systems for , San Diego, CA. October, 2008. Nathanson D, Sun J, Kamei K, Huang T, Ohashi M, Wang H, Masterman-Smith M, van Dam M, Kornblum H., Mischel P, Tseng H. Micro-Pathology Chips (PLCs) for PI3K Signaling Pathway Profiling in Glioblastoma An Example Toward Personalized Medicine. Investigators Annual Meeting, National Cancer Institutes Nanotechnology Alliance for Cancer, Chapel Hill, NC, October 16-18, 2007. Nakano I, Jackson R, Masterman-Smith M, Paucar A, Liau L, Lazareff J, Geschwind D, Nelson S, Mischel P, Kornblum H. Identification of maternal embryonic leucine zipper kinase (MELK) as an important regulator of glioblastoma multiforme and medulloblastoma proliferation and survival. Annual Meeting of the Society for Neuroscience, Washington, DC, November 12-16, 2005. Kornblum H, Hemmati H, Nakano I, Masterman-Smith M, Bronner-Fraser M., Lazareff J, Nelson S, Liau L, Mischel P, Geschwind D. Neural stem cells, brain tumors, and brain tumor stem cells. Annual Meeting of the American Association of Cancer Research, (Review Article) Proc Amer Assoc Cancer Res 2005;46:[SY23] Anaheim, CA, April 16-20, 2005. Tao ML, Masterman-Smith M., Garvie P, OLeary T, Parsons S. Quality of Life Assessment (QUOLA) in pediatric brain tumor population: Feasibility and measurement properties of a new brain-specific instrument. Annual Meeting of the International Symposium on Pediatric Neuro-Oncology, Boston, MA. Neuro-oncology 6:448, 2004. Shields D, Masterman-Smith M, Bababeggey S, Alger J, Lazareff JA. 1HMagnetic Resonance Spectroscopic Imaging analysis of occipital lobe anatomy in blind and non-blind pediatric patients. Annual Meeting of the American Association of Neurological Surgeons, Orlando, FL May 1-6, 2004. Spinks TJ, Masterman-Smith M, Lowry A., Lazareff, JA. Neurosurgical interventions in developing countries: A new model for a new age. Annual Meeting of

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the American Association of Neurological Surgeons, San Diego, CA, April 26-May 1, 2003. Spinks TJ, Masterman-Smith M, Tach V, Lazareff JA. Diagnostic delay in low grade pediatric intracranial tumors. Annual Meeting of the American Association of Neurological Surgeons, San Diego, CA, April 26-May 1, 2003. Tao ML, Masterman-Smith M, Parsons S. Quality of Life Assessment (QUOLA) tool for pediatric brain tumor patients: lessons learned. Presented at the Annual Meeting of the American Society of Clinical Oncology, Orlando, FL, May 18, 2002. VI. Patent Filings: Tseng HR, Kamei K., Sun J, Masterman-Smith M., Mischel PS, Nathanson D, Huang T, Sarkaria SM, Behrenbuch C, van Dam, RM. Microfluidic Cell Culture Array for Drug Screening and Image Probe Discovery. U.S. application 61/006,842 based on international patent application. Kornblum HI, Geschwind DH, Nakano I, Dougherty JD, Lazareff JA, Mischel PS, Masterman-Smith M, Huang J. Compositions and Methods for Diagnosing and Treating Brain Cancer and Identifying Neural Stem Cells. U.S. application 11/576,444 based on international patent application. VII. Awards

Best Poster, Investigators Meeting, Alliance for Nanotechnology in Cancer, National Cancer Institute, Chapel Hill, NC, 2007. Travel Award, UCLA Department of Molecular and Medical Pharmacology, 2008.

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