Phadiatop (Inhalant Atopy Screen)

Test Names: Test Code: CPT Code: Phadiatop (Inhalant Atopy Screen) or Aeroallergen Yes/No Test 200 86005 by their primary care physician, were later evaluated clinically and with the Phadiatop. Only 35% (or 86/244) of these patients had Type I (IgE mediated) allergic disease. For those without IgE, the use of Claritin would not be indicated. References: (1) Eriksson NE. Allergy screening with Phadiatop and CAP Phadiatop in combination with a questionnaire in adults with asthma and rhinitis. Allergy 1990; 45: 285-292. (2) Matricardi PM et al. The sure of Phadiatop in massscreening programmes of inhalant allergies: advantages and limitations Clincial and Experimental Allergy 1990; 20: 151-155. (3) Herold DA et al. Phadiatop versus total IgE. A comparison study on the efficiency of two screening methods in the diagnosis of inhalant allergies. Allergologie 1987; 10: 300-303. (4) Williams PB, Siegel C, Portnoy J. Efficacy of a single diagnostic test for sensitization to common inhalant allergens. Annals of Allergy, Asthma & Immunology 2001; 86: in press. For more information, contact Clinical Use: The major use of the test is to help the primary care physician rule out allergy (IgE-mediated disease) as the cause of a patients symptoms. Since inhalant allergy symptoms can be elusive and may resemble a bacterial or viral infection, a reliable atopy or allergy screen is often very cost effective. This test provides an accurate basis for the physician to decide on whether to refer the patient to an allergy specialist, institute general allergen avoidance procedures or to treat with one of the newer non-sedating antihistamines. Interpretation: An individual with inhalant allergy should be positive on this test. The clinical accuracy of this test has been documented by many studies in peerreviewed journals. The ImmunoCAP Phadiatop was shown to have sensitivity of 96% and a specificity of 94% when compared to a diagnosis made by history and skin testing. The Phadiatop test includes a balanced mixture of pollens from important trees, weeds, and grasses and also several other key antigens, including cat, dust mite and mold. Note that the test does not include any allergens from foods, venoms or drugs. A recent study performed at IBT Reference Lab demonstrated a diagnostic efficiency greater thatn 98% (4). In a different study, 244 patients on Claritin, who had a presumptive diagnosis of allergy

Description: The Phadiatop test is a simple yes/no serum test for the presence of inhalant IgE-mediated allergy. The ImmunoCAP Phadiatop is based on the allergosorbent principle and uses a balanced mixture of relevant allergens that frequently cause inhalant allergy. These are covalently attached to the flexible hydrophilic carrier in the ImmunoCAP capsule. Method: Enzyme Immunoassay. The ImmunoCAP Phadiatop test is a fluroescence substrate enzyme immunoassay system from Phadia. Units Reported: Positive or Negaitve Reference/Normal Value: Negative Specimen Requirements: 1 mL serum. Collect blood with a red top or SST and centrifuge to obtain serum (150 L is the minimum volume).

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