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Product Information

S1268 IC-87114
PI3K

Novel Life Science Reagents


for Cell Signaling Research

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Technical Data:
M.Wt: Formula: Solubility: Purity: Storage: CAS No.: 397.43 C22H19N7O DMSO 99% at -20 2 years 371242-69-2

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Biological Activity
IC87114 is the first isoform-selective PI3K inhibitor. This quinazolinone purine inhibits p110 (IC50=0.13M) at mid-nanomolar concentrations and shows 1001000-fold selectivity over other class I PI3Ks (p110, p110 and p110 ). The selectivity of IC87114 is remarkable given that the residues that line the ATP binding pocket of the class I PI3Ks are highly conserved. [1,2]

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References
[1] Marone R et al. Biochim Biophys Acta. 2008 Jan;1784(1):159-85 [2] Z.A. Knight and K.M. Shokat. Biochemical Society Transactions.2007,35:245-249

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Please inspect packages immediately upon receipt and notify customer service within 3 days of delivery of any damage or discrepancies.Our team will take quick and appropriate action to correct any problem.

MSDS & CoA


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Notes
PLEASE KEEP THE PRODUCT UNDER -20 FOR LONG-TERM STORAGE. NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
Specific storage and handling information for each product is indicated on the product datasheet. Most Selleckchem products, stored under the recommended conditions, are stable for two years. Products are sometimes shipped at a temperature that differs from the recommended storage temperature,most are recommended stored at -20.Many products are stable in the short-term at temperatures that differ from that required for long-term storage. We ensure that the product is shipped under conditions that will maintain the quality of the product, but save your shipping charges by using the most economical storage conditons for an overnight shipment. Upon receipt of the product, follow the storage recommendations on the product data sheet.

be received from our customer service team. Returns accepted will be subject to a 30% restocking charge.

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