Documenti di Didattica
Documenti di Professioni
Documenti di Cultura
Amount
The
CSF
is
produced
in
the
choroid
plexus
at
a
rate
of
500
ml/day.
Since
the
brain
can
contain
only
from
135
to
150
ml,
it
is
drained
into
the
blood
stream
through
arachnoid
granula3ons
in
the
superior
sagiOal
sinus.
Thus
the
CFS
uid
is
replaced
two
to
four
3mes
daily.
Cons3tu3on
0.3%
plasma
proteins
2
to
5
lympocytes/ml
There
are
quan3ta3ve
dierences
in
the
distribu3ons
of
a
number
of
proteins
in
the
CSF.
Globular
proteins
and
albumins
are
in
lower
concentra3on
in
ventricular
CSF
compared
to
lumbar
or
cisternal
uid.
CSF
pressure
ranges
from
4.47.3
mmHg
Func3on
of
CNF
Buoyancy:
The
actual
mass
of
the
human
brain
is
about
1400
grams;
however
the
net
weight
of
the
brain
suspended
in
the
CSF
is
equivalent
to
a
mass
of
25
grams.
The
brain
therefore
exists
in
neutral
buoyancy,
which
allows
the
brain
to
maintain
its
density
without
being
impaired
by
its
own
weight.
Protec3on:
The
CSF
protects
the
brain
3ssue
from
injury
when
jolted
or
hit.
In
certain
situa3ons
such
as
automobile
accidents
or
sports
injuries,
the
CSF
cannot
protect
the
brain
from
forced
contact
with
the
skull
case,
causing
hemorrhaging,
brain
damage,
and
some3mes
death.
Chemical Stability: The CSF rinses the metabolic waste that enters the central nervous system through the blood-brain barrier. This allows for homeosta3c regula3on of the distribu3on of neuroendocrine factors, to which even slight changes can cause problems or damage to the nervous system. For example, high glycine concentra3on disrupts temperature and blood pressure control, and high CSF pH causes dizziness and syncope(loss of consciousness). Preven3on of brain ischemia: The preven3on of brain ischemia is made by decreasing the amount of CSF in the limited space inside the skull. This decreases total intracranial pressure and facilitates blood perfusion (the process of nutri3ve delivery of arterial blood to a capillary bed in the biological 3ssue).
Choroid
Plexus
Site
of
CFS
produc3on
It
is
present
in
all
components
of
the
ventricular
system
except
for
the
cerebral
aqueduct
and
the
occipital
&
frontal
horns
of
the
lateral
ventricles.
The
choroid
plexus
consists
of
many
capillaries,
separated
from
the
ventricles
by
choroid
epithelial
cells(ion-transpor3ng
epithelium).
CFS
Circula3on
It
ows
from
the
lateral
ventricles
into
the
third
ventricle,
and
there
through
the
aqueduct
into
the
forth
ventricle.
Here
it
passes
though
the
median
and
lateral
apertures
into
the
external
cerebrospinal
uid
spaces.
Drainage
of
the
CFS
occurs
partly
in
the
arachnoid
granula3ons
that
protrude
into
the
venous
sinuses
or
lateral
lacunae,
and
partly
at
the
exits
of
the
spinal
nerves
where
the
uid
enters
into
the
dense
venous
plexuses
and
into
the
nerve
sheaths
(drainage
into
lympa3c
circula3on).