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Product Information

S1224 Oxaliplatin
Technical Data:
M.Wt: Formula: Solubility: Purity: Storage: CAS No.: 397.29 C8H14N2O4Pt Unknown 99% at -20 2 years 61825-94-3 O H2 N O Pt O O N H2 Synonyms: Eloxatin

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Biological Activity
Cytotoxicity of platinum drugs is believed to result from the formation of platinum-DNA adducts. Eukaryotic cells respond to the presence of oxaliplatin adducts in DNA by activating signal transduction pathways that result in cell cycle arrest, an increase in DNA repair activity and apoptosis.[2] Oxaliplatin was found to be active against C32 and G361 cell lines with IC50 values of 49.48 and 9.07 M (1 h exposure), 9.47 and 1.30 M (4 h exposure), and 0.98 and 0.14 M (24 h exposure), respectively. [3]

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References
[1] Christin Tse et al. Cancer Res. 2008 May 1;68:3421-3428 [2] Alex R. Shoemaker et al. Clinical Cancer Research. 2008 June 1;14:3268-3277 [3] Mohammed MQ, Retsas S. Anticancer Drugs. 2000 Nov;11(10):859-63

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Notes
PLEASE KEEP THE PRODUCT UNDER -20 FOR LONG-TERM STORAGE. NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
Specific storage and handling information for each product is indicated on the product datasheet. Most Selleck products, stored under the recommended conditions, are stable for two years. Products are sometimes shipped at a temperature that differs from the recommended storage temperature,most are recommended stored at -20 Many products are stable in the short-term at temperatures that differ from that . required for long-term storage. We ensure that the product is shipped under conditions that will maintain the quality of the product, but save your shipping charges by using the most economical storage conditons for an overnight shipment. Upon receipt of the product, follow the storage recommendations on the product data sheet.

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