Product Information

S1207 AV-951
Technical Data:
M.Wt: Formula: Solubility: Purity: Storage: CAS No.: 454.86 C22H19ClN4O5 DMSO 99% at -20 2 years 475108-18-0
O O O NH NH O N Cl N O

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Synonyms: Tivozanib

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Biological Activity
AV-951(Tivozanib) is an orally bioavailable potent VEGFR-1, 2 and 3, cKit and PDGFR inhibitor with IC50 of 0.21, 0.16, 0.24, 1.63 and 1.72 nM, respectively.AV-951(Tivozanib) has potential antiangiogenic and antineoplastic activities. AV-951(Tivozanib) inhibits c-Kit and PDGFR at 10-times higher concentrations. AV-951(Tivozanib) is a novel oral quinoline urea derivative. Preclinical data indicate that AV-951 blocks the proliferation and migration of endothelial cells in vitro, and suppresses angiogenesis and growth of human tumor xenografts in vivo. Tivozanib has been shown to be safe and orally bioavailable when given to cancer patients. AV-951(Tivozanib) is under early clinical investigation for the treatment of renal cell carcinoma and non-small cell lung carcinoma, as well as in combination with other chemotherapies in breast, colorectal, and other gastrointestinal cancer patients. [1][2]

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References
[1] http://meeting.ascopubs.org/cgi/content/abstract/27/15S/5032 [2] Campas et al. Drugs Fut. 2009, 34(10): 793

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Notes
PLEASE KEEP THE PRODUCT UNDER -20 FOR LONG-TERM STORAGE. NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
Specific storage and handling information for each product is indicated on the product datasheet. Most Selleck products, stored under the recommended conditions, are stable for two years. Products are sometimes shipped at a temperature that differs from the recommended storage temperature,most are recommended stored at -20 Many products are stable in the short-term at temperatures that differ from that . required for long-term storage. We ensure that the product is shipped under conditions that will maintain the quality of the product, but save your shipping charges by using the most economical storage conditons for an overnight shipment. Upon receipt of the product, follow the storage recommendations on the product data sheet.

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