Product Information

S1169 TGX-221
PI3K

Novel Life Science Reagents

for Cell Signaling Research

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Technical Data:
M.Wt: Formula: Solubility: Purity: Storage: CAS No.: 364.44 C21H24N4O2 DMSO 99% at -20 2 years 663619-89-4
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Biological Activity
TGX-221 is a potent, selective, and cell permeable inhibitor of PI3K p110 .[1,2] Thrombogenix compound TGX-221 is a LY294002 analogue, able to inhibit selectively the PI3K isoform in vitro. The chromone core of LY294002 was replaced with pyrido[1,2-a] pyrimidin-4-one and inserted into an aryl ring moiety, increasing the potency and selectivity against PI3K (IC50=10nM).[1] TGX-221 is a low-nanomolar range inhibitor, shows about 1000-fold higher selectivity over PI3K, and is cell permeable. TGX-221 interfered with shear stress-induced PtdIns(3,4)P2 production and integrin IIb3-mediated adhesion in platelets, suggesting that inhibition of PI3K might have an anti-thrombotic potential in vivo.[1]

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References
[1] Marone R et al. Biochim Biophys Acta. 2008 Jan;1784(1):159-85 [2] Jackson SP et al. Nat Med. 2005 May;11(5):507-14

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MSDS & CoA

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Notes
PLEASE KEEP THE PRODUCT UNDER -20 FOR LONG-TERM STORAGE. NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
Specific storage and handling information for each product is indicated on the product datasheet. Most Selleck products, stored under the recommended conditions, are stable for two years. Products are sometimes shipped at a temperature that differs from the recommended storage temperature,most are recommended stored at -20 Many products are stable in the short-term at temperatures that differ from that . required for long-term storage. We ensure that the product is shipped under conditions that will maintain the quality of the product, but save your shipping charges by using the most economical storage conditons for an overnight shipment. Upon receipt of the product, follow the storage recommendations on the product data sheet.

be received from our customer service team. Returns accepted will be subject to a 30% restocking charge.

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