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Product Information

S1145 SNS-032
CDK

Novel Life Science Reagents


for Cell Signaling Research

Toll Free:
(877)796-6397
-- USA and Canada only --

Fax:
+1-713-796-9816

Technical Data:
M.Wt: Formula: Solubility: Purity: Storage: CAS No.: 379.54 C17H24N4O2S2 DMSO 99% at -20 2 years 345627-80-7

Orders
+1-713-922-4115 enquiry@selleckchem.com

Tech Support
tech@selleckchem.com

Synonyms: BMS-387032

(chemistry support)

techbio@selleckchem.com
(bio support)

Biological Activity
SNS-032 (formerly BMS-387032) is a small-molecule cyclin-dependent kinase (CDK) inhibitor for the treatment of B-cell malignancies and advanced solid tumors. [1] Preclinical studies have shown that SNS-032 is a specific and potent inhibitor of CDK2, 7 and 9 which induces cell cycle arrest and apoptosis in tumor cell lines. It was shown to inhibit in vitro angiogenesis and prostaglandin E2 (PGE2) production, both strongly associated with tumorigenesis. Phase I clinical trials support the safety and tolerability of SNS-032 as evaluated in dose-escalation studies. The compound is currently administered by i.v. infusion but has shown promising potential for oral delivery. [2,3]

Web
www.selleckchem.com

Selleck Overnight Delivery Service

References
[1] Misra RN et al. J Med Chem. 2004 Mar 25;47(7):1719-28 [2] Ali MA et al. Neoplasia. 2007 May;9(5):370-81 [3] Heath EI et al. Invest New Drugs. 2008 Feb;26(1):59-65

Return Policy
Please inspect packages immediately upon receipt and notify customer service within 3 days of delivery of any damage or discrepancies.Our team will take quick and appropriate action to correct any problem.

MSDS & CoA


Please visit www.selleckchem.com to download MSDS and CoA.

Goods ordered in error can only be accepted for return if made within 3 days of delivery, are unopened,have been stored correctly and are in good condition. Should you wish to return any item(s), prior authorization must

Notes
PLEASE KEEP THE PRODUCT UNDER -20 FOR LONG-TERM STORAGE. NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
Specific storage and handling information for each product is indicated on the product datasheet. Most Selleck products, stored under the recommended conditions, are stable for two years. Products are sometimes shipped at a temperature that differs from the recommended storage temperature,most are recommended stored at -20 Many products are stable in the short-term at temperatures that differ from that . required for long-term storage. We ensure that the product is shipped under conditions that will maintain the quality of the product, but save your shipping charges by using the most economical storage conditons for an overnight shipment. Upon receipt of the product, follow the storage recommendations on the product data sheet.

be received from our customer service team. Returns accepted will be subject to a 30% restocking charge.

For all product returns and product replacements,please contact Selleck directly by info@selleckchem.com or +1-713-922-4115 Please have on hand, the invoice number, purchase order number,air bill number and approximate date of shipment/receipt.

Copyright 2010 Selleck chemicals.

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