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Product Information

S1144 VX-770

» CFTR

Technical Data:

M.Wt:

392.49

Formula:

C24H28N2O3

Solubility:

DMSO

Purity:

99%

Storage:

at -202 years

CAS No.:

873054-44-5

H N H N O O OH
H
N
H
N
O O
OH

Biological Activity

VX-770 is a CFTR potentiator with an IC50 of 43 ± 38 nM. In recombinant cells VX-770 increased CFTR channel open probability (P(o)) in both the F508del processing mutation and the G551D gating mutation. VX-770 also increased Cl(-) secretion in cultured human CF bronchial epithelia (HBE) carrying the G551D gating mutation on one allele and the F508del processing mutation on the other allele by approximately 10-fold, to approximately 50% of that observed in HBE isolated from individuals without CF. Furthermore, VX-770 reduced excessive Na(+) and fluid absorption to prevent dehydration of the apical surface and increased cilia beating in these epithelial cultures. [1][2]

References

[1] Van Goor F et al. Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18825-30

[2] Sloane PA et al. Curr Opin Pulm Med. 2010 Sep 8

MSDS & CoA

Please visit www.selleckchem.com to download MSDS and CoA.

Notes

PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE. NOT FOR HUMAN OR VETERINARY DIAGNOSTIC
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. Novel Life Science Reagents for Cell Signaling

Novel Life Science Reagents

for Cell Signaling Research

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