Product Information

S1052 Elesclomol
HSP-70

Novel Life Science Reagents

for Cell Signaling Research

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Technical Data:
M.Wt: Formula: Solubility: Purity: Storage: CAS No.: 400.5 C19H20N4O2S2 DMSO 99% at -20 2 years 488832-69-5
O N S N H O N H N S

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Synonyms: STA-4783

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(bio support)

Biological Activity
Elesclomol (STA-4783) is a small molecule that induces apoptosis via the mitochondrial apoptotic pathway in cancer cells by increasing oxidative stress, while having little or no effect on normal cells. It is a pro-apoptotic agent that demonstrates anti-tumor activity against a broad range of cancer cell types. It promotes apoptosis in Hs294T melanoma cells treated with 100 nmol/L for six hours by rapidly generating reactive oxygen species and inducing the transcription of Hsp70 and metallothionein.1 Stage III clinical trials to assess efficacy of elesclomol treatment in combination with paclitaxel2, 1 in patients with stage IV metastatic melanoma were suspended due to safety concerns.

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References
[1] Anna Berkenblit et al. Clinical Cancer Research.2007 January;13(2) :584-590. [2] Revill P. et al. Drugs of the Future. 2008 April; 33(4):310-315.

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Please inspect packages immediately upon receipt and notify customer service within 3 days of delivery of any damage or discrepancies.Our team will take quick and appropriate action to correct any problem.

MSDS & CoA

Please visit www.selleckchem.com to download MSDS and CoA.

Goods ordered in error can only be accepted for return if made within 3 days of delivery, are unopened,have been stored correctly and are in good condition. Should you wish to return any item(s), prior authorization must

Notes
PLEASE KEEP THE PRODUCT UNDER -20 FOR LONG-TERM STORAGE. NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
Specific storage and handling information for each product is indicated on the product datasheet. Most Selleck products, stored under the recommended conditions, are stable for two years. Products are sometimes shipped at a temperature that differs from the recommended storage temperature,most are recommended stored at -20 Many products are stable in the short-term at temperatures that differ from that . required for long-term storage. We ensure that the product is shipped under conditions that will maintain the quality of the product, but save your shipping charges by using the most economical storage conditons for an overnight shipment. Upon receipt of the product, follow the storage recommendations on the product data sheet.

be received from our customer service team. Returns accepted will be subject to a 30% restocking charge.

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