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Product Information

Technical Data:

M.Wt:

406.47

Formula:

C21H30N2O6

Solubility:

Unknown

Purity:

99%

Storage:

at -202 years

CAS No.:

238750-77-1

O O N H O O HO HN OH
O
O
N
H
O
O
HO
HN OH

Synonyms: Tosedostat

Biological Activity

Tosedostat (formerly CHR-2797) is an aminopeptidase inhibitor with IC50 of 100, 150, 220, >1000, >5000, >10000 and >30000 nM for LAP, PuSA, aminopeptidase N, aminopeptidase B, PILSAP, LTA4 hydrolase and MetAP2, respectively. It has demonstrated anti-tumour activity in a number of models of cancer, both as a single agent and in synergy with cytotoxic agents such as carboplatin and paclitaxel. [1][2]

References

[1] Krige D et al. Cancer Res. 2008 Aug 15;68(16):6669-79

[2] Reid AH et al. Clin Cancer Res. 2009 Aug 1;15(15):4978-85

MSDS & CoA

Please visit www.selleckchem.com to download MSDS and CoA.

Notes

PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE. NOT FOR HUMAN OR VETERINARY DIAGNOSTIC
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. Novel Life Science Reagents for Cell Signaling

Novel Life Science Reagents

for Cell Signaling Research

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info@selleckchem.com or

recommended conditions, are stable for two years. Products are sometimes shipped at a temperature that differs from the recommended

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